Search Results - "Cullen, Kirsty S."

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes by Arden, Catherine, Tudhope, Susan J, Petrie, John L, Al-Oanzi, Ziad H, Cullen, Kirsty S, Lange, Alex J, Towle, Howard C, Agius, Loranne

“…Glucose metabolism in the liver activates the transcription of various genes encoding enzymes of glycolysis and lipogenesis and also G6pc…”
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Glucagon-Like Peptide 1 Protects Pancreatic β-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function by Zummo, Francesco P, Cullen, Kirsty S, Honkanen-Scott, Minna, Shaw, James A M, Lovat, Penny E, Arden, Catherine

“…Studies in animal models of type 2 diabetes have shown that glucagon-like peptide 1 (GLP-1) receptor agonists prevent β-cell loss. Whether GLP-1 mediates…”
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Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis by Zummo, Francesco P, Krishnanda, Stanislaus I, Georgiou, Merilin, O'Harte, Finbarr PM, Parthsarathy, Vadivel, Cullen, Kirsty S, Honkanen-Scott, Minna, Shaw, James AM, Lovat, Penny E, Arden, Catherine

“…Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2…”
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Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein by Cullen, Kirsty S., Al-Oanzi, Ziad H., O'Harte, Finbarr P.M., Agius, Loranne, Arden, Catherine

“…Glucokinase activity is a major determinant of hepatic glucose metabolism and blood glucose homeostasis. Liver glucokinase activity is regulated acutely by…”
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Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells by CULLEN, Kirsty S, MATSCHINSKY, Franz M, AGIUS, Loranne, ARDEN, Catherine

“…The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic β-cells. We tested the hypothesis that GK mutants that cause…”
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Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca 2+ -PPP3/calcineurin-TFEB axis by Zummo, Francesco P, Krishnanda, Stanislaus I, Georgiou, Merilin, O'Harte, Finbarr Pm, Parthsarathy, Vadivel, Cullen, Kirsty S, Honkanen-Scott, Minna, Shaw, James Am, Lovat, Penny E, Arden, Catherine

“…Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2…”
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Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic [beta]-cells.(ORIGINAL ARTICLE) by Cullen, Kirsty S, Matschinsky, Franz M, Agius, Loranne, Arden, Catherine

“…OBJECTIVE--The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic [Beta]-cells. We tested the hypothesis that GK mutants…”
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