Search Results - "Cull, Alyssa H"

Exploiting Single-Cell Tools in Gene and Cell Therapy by Bode, Daniel, Cull, Alyssa H, Rubio-Lara, Juan A, Kent, David G

“…Single-cell molecular tools have been developed at an incredible pace over the last five years as sequencing costs continue to drop and numerous molecular…”
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Identification and characterization of in vitro expanded hematopoietic stem cells by Che, James L C, Bode, Daniel, Kucinski, Iwo, Cull, Alyssa H, Bain, Fiona, Becker, Hans J, Jassinskaja, Maria, Barile, Melania, Boyd, Grace, Belmonte, Miriam, Zeng, Andy G X, Igarashi, Kyomi J, Rubio‐Lara, Juan, Shepherd, Mairi S, Clay, Anna, Dick, John E, Wilkinson, Adam C, Nakauchi, Hiromitsu, Yamazaki, Satoshi, Göttgens, Berthold, Kent, David G

“…Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have…”
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Tet2 restrains inflammatory gene expression in macrophages by Cull, Alyssa H., Snetsinger, Brooke, Buckstein, Rena, Wells, Richard A., Rauh, Michael J.

“…•Tet methylcytosine dioxygenase 2 (Tet2)-deficient macrophages show increased lipopolysaccharide-induced and spontaneous inflammation.•Tet2 restrains…”
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Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders by Cull, Alyssa H., Kent, David G., Warren, Alan J.

“…[Display omitted] Ribosomopathy Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive inherited bone marrow failure syndrome (IBMFS) caused by…”
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Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117 by Sekeres, Mikkael A, Othus, Megan, List, Alan F, Odenike, Olatoyosi, Stone, Richard M, Gore, Steven D, Litzow, Mark R, Buckstein, Rena, Fang, Min, Roulston, Diane, Bloomfield, Clara D, Moseley, Anna, Nazha, Aziz, Zhang, Yanming, Velasco, Mario R, Gaur, Rakesh, Atallah, Ehab, Attar, Eyal C, Cook, Elina K, Cull, Alyssa H, Rauh, Michael J, Appelbaum, Frederick R, Erba, Harry P

“…Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes (MDS). Whether azacitidine-based combinations with lenalidomide or…”
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Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes by Cull, Alyssa H., Rauh, Michael J.

“…Review on how marrow cells contribute to the abnormal MDS microenvironment, and how they may be targeted through novel therapeutics. Myelodysplastic syndromes…”
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Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease by Spencer Chapman, Michael, Cull, Alyssa H., Ciuculescu, Marioara F., Esrick, Erica B., Mitchell, Emily, Jung, Hyunchul, O’Neill, Laura, Roberts, Kirsty, Fabre, Margarete A., Williams, Nicholas, Nangalia, Jyoti, Quinton, Joanne, Fox, James M., Pellin, Danilo, Makani, Julie, Armant, Myriam, Williams, David A., Campbell, Peter J., Kent, David G.

“…Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell disease (SCD); however, the occurrence of myeloid malignancies…”
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Increased CXCL10 (IP-10) is associated with advanced myeloproliferative neoplasms and its loss dampens erythrocytosis in mouse models by Belmonte, Miriam, Cabrera-Cosme, Lilia, Øbro, Nina F., Li, Juan, Grinfeld, Jacob, Milek, Joanna, Bennett, Ellie, Irvine, Melissa, Shepherd, Mairi S., Cull, Alyssa H., Boyd, Grace, Riedel, Lisa M., Chi Che, James Lok, Oedekoven, Caroline A., Baxter, E. Joanna, Green, Anthony R., Barlow, Jillian L., Kent, David G.

“…•IP-10 correlates with disease severity and the presence of JAK2 and TET2 mutations•Mouse models have similarly dysregulated IP-10 expression as patients•IP-10…”
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3057 – NOVEL IMMUNE CELL SUBSETS REVEALED USING THE FGD5 REPORTER MOUSE by Cull, Alyssa H., Che, James, Davey, John, Bode, Daniel, Boyd, Grace, Belmonte, Miriam, Shepherd, Mairi, Barlow, Jillian, Kent, David

“…The Fgd5 reporter mouse strain has been widely used to facilitate the identification of hematopoietic stem cells (HSCs) and to undertake lineage tracing of…”
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Clonal Tracking By Whole Genome Sequencing Permits Comprehensive Mapping of the Genomic Landscape in Pre- and Post-Gene Therapy Sickle Cell Patients by Cull, Alyssa H., Spencer Chapman, Michael, Ciuculescu, Marioara, Mitchell, Emily, Armant, Myriam, Boyd, Grace, Esrick, Erica B., Williams, David A., Campbell, Peter J., Kent, David G.

“…▪ Recent advances in clonal stem cell tracking strategies have enabled interrogation of unperturbed human hematopoiesis. Whole genome sequencing (WGS) can be…”
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Identification and characterization of invitro expanded hematopoietic stem cells by Che, James L C, Bode, Daniel, Kucinski, Iwo, Cull, Alyssa H, Bain, Fiona, Becker, Hans J, Jassinskaja, Maria, Barile, Melania, Boyd, Grace, Belmonte, Miriam, Zeng, Andy G X, Igarashi, Kyomi J, Juan Rubio‐Lara, Shepherd, Mairi S, Clay, Anna, Dick, John E, Wilkinson, Adam C, Nakauchi, Hiromitsu, Yamazaki, Satoshi, Göttgens, Berthold, Kent, David G

“…Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have…”
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The role of ALDH1A3 in normal and transformed mammary gland development by Cull, Alyssa H

“…Aldehyde dehydrogenases (ALDHs) have been used as stem cell markers in a variety of tissues, including the breast. However, it is currently unknown whether…”
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