Search Results - "Cukan, Michael"

Optimization of humanized IgGs in glycoengineered Pichia pastoris by Gerngross, Tillman U, Li, Huijuan, Sethuraman, Natarajan, Stadheim, Terrance A, Zha, Dongxing, Prinz, Bianka, Ballew, Nicole, Bobrowicz, Piotr, Choi, Byung-Kwon, Cook, W James, Cukan, Michael, Houston-Cummings, Nga Rewa, Davidson, Robert, Gong, Bing, Hamilton, Stephen R, Hoopes, Jack P, Jiang, Youwei, Kim, Nam, Mansfield, Renee, Nett, Juergen H, Rios, Sandra, Strawbridge, Rendall, Wildt, Stefan

“…As the fastest growing class of therapeutic proteins, monoclonal antibodies (mAbs) represent a major potential drug class. Human antibodies are glycosylated in…”
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Production of monoclonal antibodies by glycoengineered Pichia pastoris by Potgieter, Thomas I., Cukan, Michael, Drummond, James E., Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Lynaugh, Heather, Mallem, Muralidhar, McKelvey, Troy W., Mitchell, Teresa, Nylen, Adam, Rittenhour, Alissa, Stadheim, Terrance A., Zha, Dongxing, d’Anjou, Marc

“…The growing antibody market and the pressure to improve productivity as well as reduce cost of production have fueled the development of alternative expression…”
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Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study by Zhang, Ningyan, Liu, Liming, Dan Dumitru, Calin, Cummings, Nga Rewa Houston, Cukan, Michael, Jiang, Youwei, Li, Yuan, Li, Fang, Mitchell, Teresa, Mallem, Muralidhar R., Ou, Yangsi, Patel, Rohan N., Vo, Kim, Wang, Hui, Burnina, Irina, Choi, Byung-Kwon, Huber, Hans E., Stadheim, Terrance A., Zha, Dongxing

“…Mammalian cell culture systems are used predominantly for the production of therapeutic monoclonal antibody (mAb) products. A number of alternative platforms,…”
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IgG2m4, an engineered antibody isotype with reduced Fc function by An, Zhiqiang, Forrest, Gail, Moore, Renee, Cukan, Michael, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Zhao, Jing Zhang, Lu, Ping, Hua, Jin, Gibson, Christopher R., Harvey, Barrett R., Montgomery, Donna, Zaller, Dennis, Wang, Fubao, Strohl, William

“…The Fc region of an antibody mediates effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity…”
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635 A novel site-directed chemical conjugation technology confers antitumor activity via native Fc receptor to plasma immunoglobulin by attaching tumor binders by Vidal, Christian, Cukan, Michael, Varma, Rajat, Iben, Lawrence, Berbasova, Tanya, Vaill, Ada, Bunin, Anna, Rossi, Ann Marie, Trinh, David, McGrath, Katy, Alvarez, Enrique, Welsch, Matthew, Rastelli, Luca

“…BackgroundWe describe KPMW101, which was created by chemical conjugation of a CD38-specific binder to clinical grade intravenous immunoglobulin (IvIg) pooled…”
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Binding of DC-SIGN to glycoproteins expressed in glycoengineered Pichia pastoris by Cukan, Michael C., Hopkins, Daniel, Burnina, Irina, Button, Michelle, Giaccone, Erin, Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Mallem, Muralidhar, Mitchell, Teresa, Moore, Renée, Nylen, Adam, Prinz, Bianka, Rios, Sandra, Sharkey, Nathan, Zha, Dongxing, Hamilton, Stephen, Li, Huijuan, Stadheim, Terrance A.

“…Previous studies have shown that glycoproteins expressed in wild-type Pichia pastoris bind to Dendritic cell-SIGN (DC-Specific Intercellular adhesion…”
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KPMW135, a Biosuperior CD3 Bispecific Version of Rituximab Created By a Novel Chemical Conjugation Technology Demonstrates Increased Anti-Tumor Activity By Adding T Cell-Mediated Cytotoxicity Activity to the Existing Mechanisms of Rituximab by Vidal, Christian, Cukan, Michael, Vaill, Ada, Bunin, Anna, Rossi, Ann Marie, Iben, Lawrence, Trinh, David, McGrath, Katy, Berbasova, Tanya, Romee, Rizwan, Alvarez, Enrique, Rastelli, Luca, Welsch, Matthew

“…Background We describe KPMW135, a novel CD20 x CD3 bispecific molecule, in which a CD3-directed ScFv (SP34) is conjugated to rituximab (RTX). RTX is a chimeric…”
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Sources of Domain and Inter-domain Stabilization in WRKY4 and GATA-1 Zn2+-stabilized DNA Binding Domains by Cukan, Michael C

“…Zn2+-stabilized DNA-binding domains are unfolded and lack secondary structure in the absence of metal ions but adopt their active, native structure upon…”
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A high-throughput purification of monoclonal antibodies from glycoengineered Pichia pastoris by Jiang, Youwei, Li, Fang, Button, Michelle, Cukan, Michael, Moore, Renee, Sharkey, Nathan, Li, Huijuan

“…Glycoengineered Pichia pastoris provides a unique platform for screening monoclonal antibody (mAb) leads and high expressing strains. A simple, economic, and…”
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Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response by Choi, Byung-Kwon, Actor, Jeffrey K, Rios, Sandra, d'Anjou, Marc, Stadheim, Terrance A, Warburton, Shannon, Giaccone, Erin, Cukan, Michael, Li, Huijuan, Kull, Angela, Sharkey, Nathan, Gollnick, Paul, Kocięba, Maja, Artym, Jolanta, Zimecki, Michal, Kruzel, Marian L, Wildt, Stefan

“…Traditional production of therapeutic glycoproteins relies on mammalian cell culture technology. Glycoproteins produced by mammalian cells invariably display…”
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Characterization of N-linked glycosylation on recombinant glycoproteins produced in Pichia pastoris using ESI-MS and MALDI-TOF by Gong, Bing, Cukan, Michael, Fisher, Richard, Li, Huijuan, Stadheim, Terrance A, Gerngross, Tillman

“…The production of recombinant therapeutic glycoproteins is an active area of research and drug development. Typically, improvements in therapeutic glycoprotein…”
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Purification process development of a recombinant monoclonal antibody expressed in glycoengineered Pichia pastoris by Jiang, Youwei, Li, Fang, Zha, Dongxing, Potgieter, Thomas I., Mitchell, Teresa, Moore, Renée, Cukan, Michael, Houston-Cummings, Nga Rewa, Nylen, Adam, Drummond, James E., McKelvey, Troy W., d’Anjou, Marc, Stadheim, Terrance A., Sethuraman, Natarajan, Li, Huijuan

“…A robust and scalable purification process was developed to quickly generate antibody of high purity and sufficient quantity from glycoengineered Pichia…”
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Erratum to “Binding of DC-SIGN to glycoproteins expressed in glycoengineered Pichia pastoris” [J. Immunol. Methods Volume 386/1–2 (2012) 34–42] by Cukan, Michael C., Hopkins, Daniel, Burnina, Irina, Button, Michelle, Giaccone, Erin, Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Mallem, Muralidhar, Mitchell, Teresa, Moore, Renée, Nylen, Adam, Prinz, Bianka, Rios, Sandra, Sharkey, Nathan, Zha, Dongxing, Hamilton, Stephen, Li, Huijuan, Stadheim, Terrance A.

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