Search Results - "Cuiffo, Benjamin G."

MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis by Cuiffo, Benjamin G., Campagne, Antoine, Bell, George W., Lembo, Antonio, Orso, Francesca, Lien, Evan C., Bhasin, Manoj K., Raimo, Monica, Hanson, Summer E., Marusyk, Andriy, El-Ashry, Dorraya, Hematti, Peiman, Polyak, Kornelia, Mechta-Grigoriou, Fatima, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, Karnoub, Antoine E.

“…Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast tumor stroma formation and to promote metastasis. Despite expanding…”
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Mesenchymal stem cells in tumor development: Emerging roles and concepts by Cuiffo, Benjamin G., Karnoub, Antoine E.

“…Mesenchymal stem cells (MSCs) are multipotent progenitor cells that participate in the structural and functional maintenance of connective tissues under normal…”
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GM-1111 reduces radiation-induced oral mucositis in mice by targeting pattern recognition receptor-mediated inflammatory signaling by Pulsipher, Abigail, Savage, Justin R, Kennedy, Thomas P, Gupta, Kavita, Cuiffo, Benjamin G, Sonis, Stephen T, Lee, Won Yong

“…Oral mucositis (OM) is a common, painful side effect of radiation therapy used for the treatment of head and neck cancer (HNC). Activation of the innate immune…”
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Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription by Kegel, Kimberly B., Meloni, Alison R., Yi, Yong, Kim, Yun J., Doyle, Erin, Cuiffo, Benjamin G., Sapp, Ellen, Wang, Yumei, Qin, Zheng-Hong, Chen, J. Don, Nevins, Joseph R., Aronin, Neil, DiFiglia, Marian

“…Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is expanded in patients with Huntington's disease (HD). We investigated…”
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Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell‐Like Phenotypic Traits in Triple‐Negative Breast Cancers by Tu, Zhenbo, Schmöllerl, Johannes, Cuiffo, Benjamin G., Karnoub, Antoine E.

“…The fibrotic tumor microenvironment is a critical player in the pathogenesis of triple‐negative breast cancers (TNBCs), with the presence of fibroblastic…”
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Lysosomal proteases are involved in generation of N-terminal huntingtin fragments by Kim, Yun J., Sapp, Ellen, Cuiffo, Benjamin G., Sobin, Lindsay, Yoder, Jennifer, Kegel, Kimberly B., Qin, Zheng-Hong, Detloff, Peter, Aronin, Neil, DiFiglia, Marian

“…N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels…”
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Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers by Thomas, Clémence, Henry, Whitney, Cuiffo, Benjamin G, Collmann, Anthony Y, Marangoni, Elisabetta, Benhamo, Vanessa, Bhasin, Manoj K, Fan, Cheng, Fuhrmann, Laetitia, Baldwin, Albert S, Perou, Charles, Vincent-Salomon, Anne, Toker, Alex, Karnoub, Antoine E

“…Basal-like breast cancers (BLBCs) exhibit hyperactivation of the phosphoinositide 3-kinase (PI3K) signaling pathway because of the frequent mutational…”
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Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis by Cuiffo, Benjamin G., Karnoub, Antoine E.

“…In a recent article in Cell Stem Cell, we showed that mesenchymal stem cells (MSCs), progenitor cells that populate the breast tumor stroma, induce…”
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Abstract 633: Gene-expression characterization of bioluminescent PDX in orthotopic and ectopic models of pancreatic cancer and metastatic triple-negative breast cancer by Cuiffo, Benjamin G., Deas, Olivier, Rankin, Ingrid, Lyng, Gregory D., Cairo, Stephano, Pedrick, Katie, Kury, Alexandra, Le Ven, Enora, Judde, Jean-Gabriel, Sonis, Stephen T.

“…Abstract Background: Patient derived xenografts (PDX) are regarded as the gold-standard for translational preclinical cancer research due to their preservation…”
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Abstract 585: Colitis in tumor-bearing mice undergoing checkpoint inhibitor therapy by Parello, Caitlin S., Cuiffo, Benjamin G., Reardon, Kasey, Fusco, Alexandria, Van Dam, Brett, Lyng, Gregory D., Sonis, Stephen T.

“…Abstract Checkpoint inhibitor (CPI) therapy represents an exciting new treatment option for patients with advanced malignancies. However, several adverse…”
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Abstract 1146: Early PD-1 inhibition abrogates PBMC engraftment in a triple-humanized (tumor/PBMC/MSC) bioluminescent orthotopic model of pancreatic cancer by Cuiffo, Benjamin G., Parello, Caitlin S., Ritchie, Chelsea, Kury, Alexandra, Anderson, Scott, Lyng, Gregory D., Sonis, Stephen T.

“…Abstract Accuracy of context is critical in efforts to improve the translational potential of preclinical oncology models. Pancreatic cancer has high mortality…”
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Abstract 5113: INTASYL self-delivering RNAi therapeutic dual targeting PD-1 and CTLA-4 provides synergistic antitumor efficacy in the treatment of murine colon cancer in vivo by Cuiffo, Benjamin G., Boone, Andrew, Yan, Dingxue, Maxwell, Melissa, Rivest, Brianna, Cardia, James, Fricker, Simon P.

“…Abstract Combination immune checkpoint inhibition (ICI) with antibodies targeting PD-1 and CTLA-4 provides superior outcomes compared to either monotherapy…”
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Abstract 1846: Intratumoral mPH-762, a self-delivering RNAi therapeutic (INTASYL™) targeting mouse PD-1, generates systemic tumor-specific memory CD8 T cells, providing a mechanism for abscopal efficacy toward untreated tumors in a murine hepatocarcinoma model by Cuiffo, Benjamin G., Boone, Andrew, Yan, Dingxue, Maxwell, Melissa, Rivest, Brianna, Cardia, James, Fricker, Simon P.

“…Abstract Intratumoral (IT) administration of immune checkpoint inhibition (ICI) holds potential to enhance local activity while decreasing systemic toxicity,…”
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Abstract 1499: Recolonizing microbiota may impact tumor response to PD-1 inhibition following antibiotic and radiotherapy treatment in a bioluminescent orthotopic model of murine lung cancer by Cuiffo, Benjamin G., Parello, Caitlin S., Ritchie, Chelsea, Rivelli, Nicholas, Kury, Alexandra, Vu, Sallyann, Gagnon, Gavin, Ritchie, Veronica, Reardon, Kasey, Costa, Catarina, Rogers, Samantha, Lyng, Gregory D., Sonis, Stephen T.

“…Abstract Mounting clinical and preclinical evidence demonstrates an important role for the intestinal microbiome in mediating efficacy of immune checkpoint…”
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Abstract 511: An assessment of pre-conditioning regimens for optimal hCD34+ hematopoietic stem cell humanization of NSGTMmice by Parello, Caitlin S., Cuiffo, Benjamin G., Kury, Alexandria, Reardon, Kasey, Dam, Brett Van, Vu, Sallyann, Costa, Catarina, Ritchie, Veronica, Gagnon, Gavin, Bateson, Timothy, Rogers, Samantha, Lyng, Gregory D., Sonis, Stephen T.

“…Abstract Humanized immune system (HIS) mice - immunocompromised Nod.Cg-Prkdcscid Il2rgtm1Wjl/SzJ animals in which the immune system has been humanized by the…”
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Abstract 2683: The gastrointestinal microbiome and its composition are critical for antitumor efficacy of immune checkpoint inhibition by anti-PD-L1 by Cuiffo, Benjamin G., Parello, Caitlin S., Ritchie, Chelsea, Pedrick, Katie, Kury, Alexandra, Costa, Catarina, Dam, Brett Van, Jung, Jonathan, Lyng, Gregory D., Sonis, Stephen T.

“…Abstract The intestinal microbiome has become increasingly appreciated as a significant mediator of systemic antitumor immunity/response in both naïve and…”
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Abstract A9: Bioluminescent orthotopic PDX models of primary pancreatic cancer and residual/metastatic breast cancer predict efficacy of standard of care and experimental treatments by Cuiffo, Benjamin G., Deas, Olivier, Lyng, Gregory D., Cairo, Stephano, Le Ven, Enora, Judde, Jean-Gabriel, Sonis, Stephen T.

“…Abstract Background: Only 5% of investigational anti-cancer agents are ultimately clinically successful. This may be attributed in part to the historical…”
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Palmitoylation of Oncogenic NRAS Is Essential for Leukemogenesis by Cuiffo, Benjamin G., Ren, Ruibao

“…Activating mutations of NRAS are found in 20%–40% of acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), and myelodysplastic syndrome (MDS)…”
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Abstract P1-07-02: Mesenchymal stem cell regulated microRNAs converge on the speech gene FOXP2 and regulate breast cancer metastasis by Cuiffo, Benjamin G, Campagne, Antoine, Bell, George W, Lembo, Antonio, Orso, Francesca, Lien, Evan, Bhasin, Manoj K, Raimo, Monica, Hanson, Summer E, Marusyk, Andriy, Hematti, Peiman, Polyak, Kornelia, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, Karnoub, Antoine E

“…Abstract About 90% of breast cancer mortalities are due to the spread of breast cancer cells (BCCs) from a primary tumor to distant organs, a process known as…”
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