Search Results - "Cui, Yinglu"

Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy by Cui, Yinglu, Chen, Yanchun, Liu, Xinyue, Dong, Saijun, Tian, Yu’e, Qiao, Yuxin, Mitra, Ruchira, Han, Jing, Li, Chunli, Han, Xu, Liu, Weidong, Chen, Quan, Wei, Wangqing, Wang, Xin, Du, Wenbin, Tang, Shuangyan, Xiang, Hua, Liu, Haiyan, Liang, Yong, Houk, Kendall N, Wu, Bian

“…Nature has provided a fantastic array of enzymes that are responsible for essential biochemical functions but not usually suitable for technological…”
Get full text

Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading by Cui, Yinglu, Chen, Yanchun, Sun, Jinyuan, Zhu, Tong, Pang, Hua, Li, Chunli, Geng, Wen-Chao, Wu, Bian

“…Biotechnological plastic recycling has emerged as a suitable option for addressing the pollution crisis. A major breakthrough in the biodegradation of…”
Get full text

Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design by Bu, Yifan, Cui, Yinglu, Peng, Ying, Hu, Meirong, Tian, Yu’e, Tao, Yong, Wu, Bian

“…Xylanases, which cleave the β-1,4-glycosidic bond between xylose residues to release xylooligosaccharides (XOS), are widely used as food additives, animal…”
Get full text

Bioretrosynthesis of Functionalized N‐Heterocycles from Glucose via One‐Pot Tandem Collaborations of Designed Microbes by Feng, Jing, Li, Ruifeng, Zhang, Shasha, Bu, Yifan, Chen, Yanchun, Cui, Yinglu, Lin, Baixue, Chen, Yihua, Tao, Yong, Wu, Bian

“…The design of multistrain systems has markedly expanded the prospects of using long biosynthetic pathways to produce natural compounds. However, the…”
Get full text

Insight into the urea binding and K166R mutation stabilizing mechanism of TlpB: Molecular dynamics and principal component analysis study by Wu, Yunjian, Zheng, Qingchuan, Xu, Yu, Chu, Wenting, Cui, Yinglu, Wang, Yan, Zhang, Hongxing

“…Chemoreceptor TlpB(Tlp=transducer-like protein), which has been demonstrated to respond to pH sensing function, is crucial for the survival of Helicobacter…”
Get full text

Computational redesign of enzymes for regio- and enantioselective hydroamination by Li, Ruifeng, Wijma, Hein J., Song, Lu, Cui, Yinglu, Otzen, Marleen, Tian, Yu’e, Du, Jiawei, Li, Tao, Niu, Dingding, Chen, Yanchun, Feng, Jing, Han, Jian, Chen, Hao, Tao, Yong, Janssen, Dick B., Wu, Bian

Get full text

Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network by Chen, Junyu, Cui, Yinglu, Zhang, Shengjie, Wu, Bian, Han, Jing, Xiang, Hua

“…Poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties and is naturally…”
Get full text

Characterization and efficient production of a thermostable, halostable and organic solvent-stable cellulase from an oil reservoir by Zhu, Tong, Li, Ruifeng, Sun, Jinyuan, Cui, Yinglu, Wu, Bian

“…The manufacture of biofuels from cellulose is regarded as one of practicable strategies to meet increasing energy demand and alleviate environmental issues…”
Get full text

Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design by Mu, Qingxuan, Cui, Yinglu, Tian, Yu'e, Hu, Meirong, Tao, Yong, Wu, Bian

“…Gluconic acid (GA) and its alkali salts are extensively used in the food, feed, beverage, textile, pharmaceutical and construction industries. However, the…”
Get full text

Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C‑Terminal Traceless Functionalization by Zhu, Tong, Cui, Yinglu, Geng, Wenchao, Liu, Guoxia, Jiang, Huifeng, Li, Ruifeng, Wu, Bian

“…The rising demand for regioselective protein modifications in chemical biology and pharmaceutical manufacturing has fueled efforts to develop diverse…”
Get full text

Computational redesign of enzymes for regio- and enantioselective hydroamination by Li, Ruifeng, Wijma, Hein J., Song, Lu, Cui, Yinglu, Otzen, Marleen, Tian, Yu’e, Du, Jiawei, Li, Tao, Niu, Dingding, Chen, Yanchun, Feng, Jing, Han, Jian, Chen, Hao, Tao, Yong, Janssen, Dick B., Wu, Bian

“…Introduction of innovative biocatalytic processes offers great promise for applications in green chemistry. However, owing to limited catalytic performance,…”
Get full text

Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366 by Li, Tao, Cui, Yinglu, Wu, Bian

“…Apoptosis is a fundamental biological phenomenon, in which anti- or proapoptotic proteins of the Bcl-2 family regulate a committed step. Overexpression of…”
Get full text

Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids by Zheng, Xinxin, Cui, Yinglu, Li, Tao, Li, Ruifeng, Guo, Lu, Li, Defeng, Wu, Bian

“…Aminotransferases (ATs) are important biocatalysts for the synthesis of chiral amines because of their capability of introducing amino group into ketones or…”
Get full text

Exploration of Transaminase Diversity for the Oxidative Conversion of Natural Amino Acids into 2‑Ketoacids and High-Value Chemicals by Li, Tao, Cui, Xuexian, Cui, Yinglu, Sun, Jinyuan, Chen, Yanchun, Zhu, Tong, Li, Chuijian, Li, Ruifeng, Wu, Bian

“…The use of 2-ketoacids is very common in feeds, food additives, and pharmaceuticals, and 2-ketoacids are valuable precursors for a plethora of chemically…”
Get full text

Development of a versatile and efficient C–N lyase platform for asymmetric hydroamination via computational enzyme redesign by Cui, Yinglu, Wang, Yinghui, Tian, Wenya, Bu, Yifan, Li, Tao, Cui, Xuexian, Zhu, Tong, Li, Ruifeng, Wu, Bian

“…Although C–N bonds are ubiquitous in natural products, pharmaceuticals and agrochemicals, biocatalysts forging these bonds with high atom-efficiency and…”
Get full text

Functional characterization of tryptophan437 at subsite +2 in pullulanase from Bacillus subtilis str. 168 by Li, Xiaoxiao, Bai, Yuxiang, Ji, Hangyan, Wang, Jinpeng, Cui, Yinglu, Jin, Zhengyu

“…Pullulanase, a typical debranching enzyme, specifically hydrolyzes α-1,6 glycosidic linkages in pullulan, starch and so on. There is accumulated knowledge…”
Get full text

The β-d- manno -heptoses are immune agonists across kingdoms by Tang, Yue, Tian, Xiaoying, Wang, Min, Cui, Yinglu, She, Yang, Shi, Zhaoxiang, Liu, Jiaqi, Mao, Huijin, Liu, Lilu, Li, Chao, Zhang, Yuwei, Li, Pengwei, Ma, Yue, Sun, Jinyuan, Du, Qing, Li, Jie, Wang, Jun, Li, De-Feng, Wu, Bian, Shao, Feng, Chen, Yihua

“…Bacterial small molecule metabolites such as adenosine-diphosphate-d- -β-d- -heptose (ADP-heptose) and their derivatives act as effective innate immune…”
Get full text

Reductase of Mutanobactin Synthetase Triggers Sequential C–C Macrocyclization, C–S Bond Formation, and C–C Bond Cleavage by Wang, Min, Xie, Zhoujie, Tang, Shoubin, Chang, Ee Ling, Tang, Yue, Guo, Zhengyan, Cui, Yinglu, Wu, Bian, Ye, Tao, Chen, Yihua

“…Mutanobactins (MUBs) and their congeners that contain a macrocycle and/or a thiazepane ring are lipopeptides from Streptococcus mutans, a major causative agent…”
Get full text

Traceless enzymatic protein synthesis without ligation sites constraint by Li, Ruifeng, Schmidt, Marcel, Zhu, Tong, Yang, Xinyu, Feng, Jing, Tian, Yu'e, Cui, Yinglu, Nuijens, Timo, Wu, Bian

“…Protein synthesis and semisynthesis offer immense promise for life sciences and have impacted pharmaceutical innovation. The absence of a generally applicable…”
Get full text

Regio‐ and Stereospecific O‐Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis by Feng, Jin, Zhang, Peng, Cui, Yinglu, Li, Kai, Qiao, Xue, Zhang, Ying‐Tao, Li, Shu‐Ming, Cox, Russell J., Wu, Bian, Ye, Min, Yin, Wen‐Bing

“…Glycosylated small molecules are often bioactive and obtained mainly via microbial biotransformation especially by fungi. However, no responsible glycosylation…”
Get full text