Search Results - "Cui, Weiren"

Assessment of AI-Based Protein Structure Prediction for the NLRP3 Target by Yin, Jian, Lei, Junkun, Yu, Jialin, Cui, Weiren, Satz, Alexander L, Zhou, Yifan, Feng, Hua, Deng, Jason, Su, Wenji, Kuai, Letian

“…The recent successes of AlphaFold and RoseTTAFold have demonstrated the value of AI methods in highly accurate protein structure prediction. Despite these…”
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Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi by Kong, Zhiwei, Zhang, Xin, Zhou, Feng, Tang, Liu, Chen, Yitong, Li, Saijie, Zhang, Xiaokang, Kuai, Letian, Su, Wenji, Cui, Weiren, Cai, Jiaxi, Wang, Yuli, Yang, Jun, Peng, You-Liang, Wang, Dongli, Liu, Junfeng

“…Blast disease caused by Magnaporthe oryzae threatens rice production worldwide, and chemical control is one of the main methods of its management. The high…”
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Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles by Huang, Tao, Cui, Weiren, Hu, Lele, Feng, Kaiyan, Li, Yi-Xue, Cai, Yu-Dong

“…More and more people are concerned by the risk of unexpected side effects observed in the later steps of the development of new drugs, either in late clinical…”
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Prediction of deleterious non-synonymous SNPs based on protein interaction network and hybrid properties by Huang, Tao, Wang, Ping, Ye, Zhi-Qiang, Xu, Heng, He, Zhisong, Feng, Kai-Yan, Hu, Lele, Cui, Weiren, Wang, Kai, Dong, Xiao, Xie, Lu, Kong, Xiangyin, Cai, Yu-Dong, Li, Yixue

“…Non-synonymous SNPs (nsSNPs), also known as Single Amino acid Polymorphisms (SAPs) account for the majority of human inherited diseases. It is important to…”
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Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering by Li, Ke, Liu, Xiaohong, Liu, Sixiu, An, Yulong, Shen, Yanfang, Sun, Qingxia, Shi, Xiaodong, Su, Wenji, Cui, Weiren, Duan, Zhiqiang, Kuai, Letian, Yang, Hongfang, Satz, Alexander L., Chen, Kaixian, Jiang, Hualiang, Zheng, Mingyue, Peng, Xuanjia, Lu, Xiaojie

“…The application of machine learning toward DNA encoded library (DEL) technology is lacking despite obvious synergy between these two advancing technologies…”
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Cooperativity among short amyloid stretches in long amyloidogenic sequences by Hu, Lele, Cui, Weiren, He, Zhisong, Shi, Xiaohe, Feng, Kaiyan, Ma, Buyong, Cai, Yu-Dong

“…Amyloid fibrillar aggregates of polypeptides are associated with many neurodegenerative diseases. Short peptide segments in protein sequences may trigger…”
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Prediction of nucleosome positioning based on transcription factor binding sites by Yi, Xianfu, Cai, Yu-Dong, He, Zhisong, Cui, Weiren, Kong, Xiangyin

“…The DNA of all eukaryotic organisms is packaged into nucleosomes, the basic repeating units of chromatin. The nucleosome consists of a histone octamer around…”
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Inter- and intra-chain disulfide bond prediction based on optimal feature selection by Niu, Shen, Huang, Tao, Feng, Kai-Yan, He, Zhisong, Cui, Weiren, Gu, Lei, Li, Haipeng, Cai, Yu-Dong, Li, Yixue

“…Protein disulfide bond is formed during post-translational modifications, and has been implicated in various physiological and pathological processes. Proper…”
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Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α‑Amino Acids and DNA-Conjugated Carbonyls by Wen, Huanan, Ge, Rui, Qu, Yi, Sun, Jialin, Shi, Xiaodong, Cui, Weiren, Yan, Hao, Zhang, Qi, An, Yulong, Su, Wenji, Yang, Hongfang, Kuai, Letian, Satz, Alexander L, Peng, Xuanjia

“…We report a DNA-compatible photoredox decarboxylative coupling of α-amino acids with carbonyl compounds to access DNA-encoded sp3-rich 1,2-amino alcohols. The…”
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Analysis and Identification of Aptamer-Compound Interactions with a Maximum Relevance Minimum Redundancy and Nearest Neighbor Algorithm by Hu, Jerry, Cui, Weiren, Lu, Jing, Zhang, Yu-Hang, Wang, ShaoPeng, Cai, Yu-Dong

“…The development of biochemistry and molecular biology has revealed an increasingly important role of compounds in several biological processes. Like the…”
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Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis by Qu, Yi, Liu, Sixiu, Wen, Huanan, Xu, Yanfen, An, Yulong, Li, Ke, Ni, Mengyuan, Shen, Yanfang, Shi, Xiaodong, Su, Wenji, Cui, Weiren, Kuai, Letian, Satz, Alexander L., Yang, Hongfang, Lu, Xiaojie, Peng, Xuanjia

“…A mild reaction for DNA-compatible, palladium promoted Suzuki-Miyaura cross-coupling reaction of potassium Boc-protected aminomethyltrifluoroborate with…”
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Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N 3 by Qu, Yi, Wen, Huanan, Ge, Rui, Xu, Yanfen, Gao, Hong, Shi, Xiaodong, Wang, Jiangong, Cui, Weiren, Su, Wenji, Yang, Hongfang, Kuai, Letian, Satz, Alexander L, Peng, Xuanjia

“…We report a DNA-compatible copper-mediated efficient synthesis of 1,2,3-triazoles via a one-pot reaction of aryl borates with TMS-N followed by a click…”
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DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β‑Unsaturated Carbonyl Compounds by An, Yu-Long, Li, Ke, Shen, Yanfang, Hong, Zibing, Chen, Linlin, Hu, Yujing, Zhou, Lichun, Wang, Disha, Shi, Xiaodong, Liu, Shien, Su, Wenji, Cui, Weiren, Kuai, Letian, Yang, Hongfang, Peng, Xuanjia

“…A robust DNA-compatible Wittig reaction mediated by PPh2CH3 has been validated for DNA-conjugated α-chloroacetamides with aldehydes and, alternatively,…”
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Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space by Han, Shuai, Guo, Xinyun, Wang, Min, Liu, Huan, Song, Yidan, He, Yunyun, Hsueh, Kuang-Lung, Cui, Weiren, Su, Wenji, Kuai, Letian, Deng, Jason

“…DNA-encoded library (DEL) technology, especially when combined with machine learning (ML), is a powerful method to discover novel inhibitors. DEL-ML can expand…”
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Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 by Chana, Chetan K., Maisonneuve, Pierre, Posternak, Ganna, Grinberg, Nicolas G.A., Poirson, Juline, Ona, Samara M., Ceccarelli, Derek F., Mader, Pavel, St-Cyr, Daniel J., Pau, Victor, Kurinov, Igor, Tang, Xiaojing, Deng, Dongjing, Cui, Weiren, Su, Wenji, Kuai, Letian, Soll, Richard, Tyers, Mike, Röst, Hannes L., Batey, Robert A., Taipale, Mikko, Gingras, Anne-Claude, Sicheri, Frank

“…Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate…”
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Abstract 427: High-quality whole-genome sequencing of FFPE samples by Bailey, Shannon T., Lund, Jim, Wang, Hao, Cui, Weiren, Hao, Chen, Sun, Hongye, Gulcher, Jeffrey R.

“…Next-generation sequencing analysis of formalin-fixed, paraffin-embedded (FFPE) samples has the potential to lead to major advances in cancer treatment and…”
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Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N3 by Qu, Yi, Wen, Huanan, Ge, Rui, Xu, Yanfen, Gao, Hong, Shi, Xiaodong, Wang, Jiangong, Cui, Weiren, Su, Wenji, Yang, Hongfang, Kuai, Letian, Satz, Alexander L, Peng, Xuanjia

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Two patients with TNK2 mutations and late onset infantile spasm by Mao, Xiao, Qian, Shuyi, Peng, Jinxin, Cui, Weiren, Lu, Gui, Zhan, Yajing

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DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines by Li, Ke, Qu, Yi, An, Yulong, Breinlinger, Eric, Webster, Matthew P, Wen, Huanan, Ding, Duanchen, Zhao, Meng, Shi, Xiaodong, Wang, Jiangong, Su, Wenji, Cui, Weiren, Satz, Alexander L, Yang, Hongfang, Kuai, Letian, Little, Andrew, Peng, Xuanjia

“…We report a DNA-compatible protocol for synthesizing amides from DNA-bound aldehydes and non-nucleophilic arylamines including aza-substituted anilines,…”
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Computationally identifying virulence factors based on KEGG pathways by Cui, Weiren, Chen, Lei, Huang, Tao, Gao, Qian, Jiang, Min, Zhang, Ning, Zheng, Lulu, Feng, Kaiyan, Cai, Yudong, Wang, Hongwei

“…Virulence factors are molecules that play very important roles in enhancing the pathogen's capability in causing diseases. Many efforts were made to…”
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