Search Results - "Cui, Guofei"
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FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora
Published in Nature communications (25-09-2019)“…Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a…”
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Sensing of H2O2-induced oxidative stress by the UPF factor complex is crucial for activation of catalase-3 expression in Neurospora
Published in PLoS genetics (01-10-2023)“…UPF-1-UPF-2-UPF-3 complex-orchestrated nonsense-mediated mRNA decay (NMD) is a well-characterized eukaryotic cellular surveillance mechanism that not only…”
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3
Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models
Published in The Journal of clinical investigation (01-06-2023)“…Many patients with hepatocellular carcinoma (HCC) do not respond to the first-line immune checkpoint inhibitor treatment. Immunization with effective cancer…”
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Author Correction: FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora
Published in Nature communications (14-01-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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5
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
Published in Cell death & disease (27-07-2023)“…Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs…”
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Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma
Published in Cell death & disease (22-06-2024)“…TBX3 behaves as a tumor suppressor or oncoprotein across cancer. However, TBX3 function remains undetermined in intrahepatic cholangiocarcinoma (iCCA), a…”
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RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues
Published in Molecular oncology (01-03-2022)“…Aberrant activation of the phosphoinositide 3‐kinase (PI3K)/AKT/mTOR and Ras/mitogen‐activated protein kinase (MAPK) pathways is a hallmark of…”
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Sensing of H.sub.2O.sub.2-induced oxidative stress by the UPF factor complex is crucial for activation of catalase-3 expression in Neurospora
Published in PLoS genetics (16-10-2023)“…UPF-1-UPF-2-UPF-3 complex-orchestrated nonsense-mediated mRNA decay (NMD) is a well-characterized eukaryotic cellular surveillance mechanism that not only…”
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9
NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition
Published in Nucleic acids research (04-09-2020)“…Abstract Negative cofactor 2 (NC2), including two subunits NC2α and NC2β, is a conserved positive/negative regulator of class II gene transcription in…”
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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
Published in Cancer research (Chicago, Ill.) (02-05-2024)“…AXIN1 is a major component of the β-catenin destruction complex and is frequently mutated in various cancer types, particularly liver cancers. Truncating AXIN1…”
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β-Catenin Sustains and Is Required for YES-associated Protein Oncogenic Activity in Cholangiocarcinoma
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2022)“…YES-associated protein (YAP) aberrant activation is implicated in intrahepatic cholangiocarcinoma (iCCA). Transcriptional enhanced associate domain…”
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TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC-induced murine hepatocarcinogenesis via centromere protein M
Published in The Journal of clinical investigation (26-09-2024)“…Activated mTORC2/AKT signaling plays a role in hepatocellular carcinoma (HCC). Research has shown that TSC/mTORC1 and FOXO1 are distinct downstream effectors…”
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