Search Results - "Cui, Cindy Qiuzhi"

Celastrol, a triterpene extracted from the Chinese thunder of god vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice by HUANJIE YANG, DI CHEN, CUI, Qiuzhi Cindy, XIAO YUAN, PING DOU, Q

“…Interest in the use of traditional medicines for cancer prevention and treatment is increasing. In vitro, in vivo, and clinical studies suggest the potential…”
Get full text

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo by Yang, Huanjie, Zhou, Ping, Huang, Hongbiao, Chen, Di, Ma, Ningfang, Cui, Qiuzhi Cindy, Shen, Shouxing, Dong, Weihua, Zhang, Xiaoyan, Lian, Wen, Wang, Xuejun, Dou, Q. Ping, Liu, Jinbao

“…Dysregulation of the ubiquitin‐proteasome pathway plays an essential role in tumor growth and development. Shikonin, a natural naphthoquinone isolated from the…”
Get full text

Proteasome inhibition in human breast cancer cells with high catechol- O-methyltransferase activity by green tea polyphenol EGCG analogs by Huo, Congde, Yang, Huanjie, Cui, Qiuzhi Cindy, Dou, Q. Ping, Chan, Tak Hang

“…A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-…”
Get full text

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity by DI CHEN, CUI, Qiuzhi Cindy, HUANJIE YANG, PING DOU, Q

“…Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used…”
Get full text

Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers by Yu, Zhiyong, Qin, Xu Long, Gu, Yan Yan, Chen, Di, Cui, Qiuzhi Cindy, Jiang, Tao, Wan, Sheng Biao, Dou, Q Ping

“…The most potent catechin in green tea is (-)-epigallocatechin-3-gallate [(-)-EGCG], which, however, is unstable under physiological conditions. To discover…”
Get full text

Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo by HAIJUN ZHANG, DI CHEN, RINGLER, Jonathan, WEI CHEN, CUI, Qiuzhi Cindy, ETHIER, Stephen P, PING DOU, Q, GUOJUN WU

“…Frequent genetic alterations of the components in the phosphoinositide 3-kinase (PI3K)/PTEN/AKT signaling pathway contribute greatly to breast cancer…”
Get full text

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells by Daniel, Kenyon G, Chen, Di, Orlu, Shirley, Cui, Qiuzhi Cindy, Miller, Fred R, Dou, Q Ping

“…A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of copper. While the precise role of copper in tumors…”
Get full text

Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti-prostate tumor effects by CHEN, Di, FREZZA, Michael, SHAKYA, Rajendra, QIUZHI CINDY CUI, MILACIC, Vesna, VERANI, Claudio N, PING DOU, Q

“…The investigation of metal-based complexes with potential antitumor activity has been of paramount importance in recent years due to the successful use of…”
Get full text

Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts by Chen, Di, Cui, Qiuzhi Cindy, Yang, Huanjie, Barrea, Raul A, Sarkar, Fazlul H, Sheng, Shijie, Yan, Bing, Reddy, G Prem Veer, Dou, Q Ping

“…Tumor growth and metastasis depend on angiogenesis that requires the cofactor copper. Consistently, high levels of copper have been found in many types of…”
Get full text

Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo by Yang, Huanjie, Wang, Ying, Cheryan, Vino T, Wu, Wenjuan, Cui, Cindy Qiuzhi, Polin, Lisa A, Pass, Harvey I, Dou, Q Ping, Rishi, Arun K, Wali, Anil

“…The medicinal plant Withania somnifera has been used for over centuries in Indian Ayurvedic Medicine to treat a wide spectrum of disorders. Withaferin A (WA),…”
Get full text

Comparative Activities of Nickel(II) and Zinc(II) Complexes of Asymmetric [NN′O] Ligands as 26S Proteasome Inhibitors by Frezza, Michael, Hindo, Sarmad Sahiel, Tomco, Dajena, Allard, Marco M, Cui, Qiuzhi Cindy, Heeg, Mary Jane, Chen, Di, Dou, Q. Ping, Verani, Cláudio N

“…In this study, we compare the proteasome inhibition capabilities of two anticancer candidates, [Ni(LIA)2] (1) and [Zn(LIA)2] (2), where LIA− is the…”
Get full text

Antitumor activity of novel fluoro-substituted (–)-epigallocatechin-3-gallate analogs by Yang, Huanjie, Sun, Dong Kui, Chen, Di, Cui, Qiuzhi Cindy, Gu, Yan Yan, Jiang, Tao, Chen, Wei, Wan, Sheng Biao, Dou, Q. Ping

“…Abstract Epidemiological studies support the cancer-preventive effects of green tea and its main constituent (–)-epigallocatechin gallate [(–)-EGCG], however,…”
Get full text

The Proteasome Is a Molecular Target of Environmental Toxic Organotins by Shi, Guoqing, Chen, Di, Zhai, Guangshu, Chen, Marina S., Cui, Qiuzhi Cindy, Zhou, Qunfang, He, Bin, Dou, Q. Ping, Jiang, Guibin

“…Background: Because of the vital importance of the proteasome pathway, chemicals affecting proteasome activity could disrupt essential cellular processes…”
Get full text

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells by Zhai, Shumei, Yang, Lei, Cui, Qiuzhi Cindy, Sun, Ying, Dou, Q. Ping, Yan, Bing

“…We have previously reported that when mixed with copper, 8-hydroxyquinoline (8-OHQ) and its analog clioquinol (CQ) inhibited the proteasomal activity and…”
Get full text

New Difluoro Knoevenagel Condensates of Curcumin, Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells by Padhye, Subhash, Yang, Huanjie, Jamadar, Abeda, Cui, Qiuzhi Cindy, Chavan, Deepak, Dominiak, Kristin, McKinney, Jaclyn, Banerjee, Sanjeev, Dou, Q. Ping, Sarkar, Fazlul H

“…Purpose Emerging evidence clearly suggests the potential chemopreventive and anti-tumor activity of a well known “natural agent” curcumin. However, studies…”
Get full text

Tea polyphenols, their biological effects and potential molecular targets by Chen, D, Milacic, V, Chen, M S, Wan, S B, Lam, W H, Huo, C, Landis-Piwowar, K R, Cui, Q C, Wali, A, Chan, T H, Dou, Q P

“…Tea is the most popular beverage in the world, second only to water. Tea contains an infusion of the leaves from the Camellia sinensis plant rich in…”
Get full text

Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells by Chen, Di, Chen, Marina S, Cui, Qiuzhi Cindy, Yang, Huanjie, Dou, Q Ping

“…Diet high in vegetables and fruits has been associated with reduced cancer risk. However, the involved mechanisms are unknown. Previously, we reported that the…”
Get full text

Inhibition of Tumor Cellular Proteasome Activity by Triptolide Extracted from the Chinese Medicinal Plant 'Thunder God Vine' by LI LU, KANWAR, Jyoti, SCHMITT, Sara, CUI, Qiuzhi Cindy, CHUANYIN ZHANG, CONG ZHAO, DOU, Q. Ping

“…The molecular mechanisms of triptolide responsible for its antitumor properties are not yet fully understood. The ubiquitin/proteasome system is an important…”
Get full text

Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors by Wan, Sheng, Yang, Huanjie, Zhou, Zhongyuan, Cui, Qiuzhi, Chen, Di, Kanwar, Jyoti, Mohammad, Imthiyaz, Dou, O, Chan, Tak

“…Curcumin (diferuloylmethane) is the main active ingredient of turmeric, a traditional herbal medicine and food of south Asia. Curcumin has been found to have a…”
Get full text

Anti-tumor activity of N -thiolated β-lactam antibiotics by Chen, Di, Falsetti, Samuel C, Frezza, Michael, Milacic, Vesna, Kazi, Aslamuzzaman, Cui, Qiuzhi Cindy, Long, Timothy E, Turos, Edward, Dou, Q. Ping

“…Abstract An ongoing strategy for cancer treatment is selective induction of apoptosis in cancer over normal cells. N -thiolated β-lactams were found to induce…”
Get full text