Search Results - "Cuffe, S"

Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations by Cheong, Jean N., Wlodek, Mary E., Moritz, Karen M., Cuffe, James S. M.

“…Babies born small are at an increased risk of developing myriad adult diseases. While growth restriction increases disease risk in all individuals, often a…”
Get full text

Let's Talk about Placental Sex, Baby: Understanding Mechanisms That Drive Female- and Male-Specific Fetal Growth and Developmental Outcomes by Meakin, Ashley S, Cuffe, James S M, Darby, Jack R T, Morrison, Janna L, Clifton, Vicki L

“…It is well understood that sex differences exist between females and males even before they are born. These sex-dependent differences may contribute to altered…”
Get full text

Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus by Fisher, Joshua J., Vanderpeet, Chelsea L., Bartho, Lucy A., McKeating, Daniel R., Cuffe, James S. M., Holland, Olivia. J., Perkins, Anthony V.

“…Key points Mitochondrial dysfunction is known to occur in diabetic phenotypes including type 1 and 2 diabetes mellitus. The incidence of gestational diabetes…”
Get full text

Is the link between elevated TSH and gestational diabetes mellitus dependant on diagnostic criteria and thyroid antibody status: a systematic review and meta-analysis by Kent, Nykola L., Young, Sophia L., Akison, Lisa K., Cuffe, James S. M.

“…Purpose Clinical studies have investigated the prevalence of gestational diabetes mellitus (GDM) in women with subclinical hypothyroidism (SCH). While some…”
Get full text

Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice by Cuffe, James S M, Saif, Zarqa, Perkins, Anthony V, Moritz, Karen M, Clifton, Vicki L

“…Maternal dexamethasone exposure in the mouse impairs placental development and programs adult disease in a sexually dimorphic manner. Glucocorticoids bind to…”
Get full text

Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model by Shrestha, Nirajan, Sleep, Simone L, Holland, Olivia J, Vidimce, Josif, Bulmer, Andrew C, Cuffe, James S M, Perkins, Anthony V, McAinch, Andrew J, Hryciw, Deanne H

“…Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters…”
Get full text

Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys by McClelland, Connie, Holland, Olivia J, Shrestha, Nirajan, Jukes, Claire L, Brandon, Anna E, Cuffe, James S M, Perkins, Anthony V, McAinch, Andrew J, Hryciw, Deanne H

“…Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is obtained from the maternal diet during pregnancy, and is essential for normal fetal growth and…”
Get full text

ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS) by Reynolds, J V, Preston, S R, O'Neill, B, Baeksgaard, L, Griffin, S M, Mariette, C, Cuffe, S, Cunningham, M, Crosby, T, Parker, I, Hofland, K, Hanna, G, Svendsen, L B, Donohoe, C L, Muldoon, C, O'Toole, D, Johnson, C, Ravi, N, Jones, G, Corkhill, A K, Illsley, M, Mellor, J, Lee, K, Dib, M, Marchesin, V, Cunnane, M, Scott, K, Lawner, P, Warren, S, O'Reilly, S, O'Dowd, G, Leonard, G, Hennessy, B, Dermott, R Mc

“…Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In…”
Get full text

Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets by Ezechukwu, Henry C, Ney, Luke J, Jarvis, Madeline A, Shrestha, Nirajan, Holland, Olivia J, Cuffe, James S M, Perkins, Anthony V, Yau, Suk-Yu, McAinch, Andrew J, Hryciw, Deanne H

“…Linoleic acid (LA) is required for neuronal development. We have previously demonstrated sex-specific changes in cardiovascular and hepatic function in rat…”
Get full text

Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring by Hofstee, Pierre, Perkins, Anthony V, Cuffe, James S M

“…Selenium deficiency during the perinatal period programs metabolic dysfunction in offspring. Postnatal exercise may prevent the development of programmed…”
Get full text

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice by Pantaleon, Marie, Steane, Sarah E., McMahon, Kathryn, Cuffe, James S. M., Moritz, Karen M.

“…Maternal stress programs offspring disease in a sexually dimorphic manner with males often more adversely affected. Previous studies of maternal glucocorticoid…”
Get full text

Proteomic Analysis of Placental Mitochondria Following Trophoblast Differentiation by Fisher, Joshua J, McKeating, Daniel R, Cuffe, James S, Bianco-Miotto, Tina, Holland, Olivia J, Perkins, Anthony V

“…As gestation proceeds the human placenta is in a constant state of renewal and placental debris is released into the maternal circulation where it can trigger…”
Get full text

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth by Hofstee, Pierre, Bartho, Lucy A., McKeating, Daniel R., Radenkovic, Filip, McEnroe, Georgia, Fisher, Joshua J., Holland, Olivia J., Vanderlelie, Jessica J., Perkins, Anthony V., Cuffe, James S.M.

“…Key points Inappropriate intake of key micronutrients in pregnancy is known to alter maternal endocrine status, impair placental development and induce fetal…”
Get full text

Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy by Cheong, Jean N, Cuffe, James S. M, Jefferies, Andrew J, Anevska, Kristina, Moritz, Karen M, Wlodek, Mary E

“…Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress during pregnancy in F1 females…”
Get full text

Maternal corticosterone in the mouse alters oxidative stress markers, antioxidant function and mitochondrial content in placentas of female fetuses by Bartho, Lucy A., Holland, Olivia J., Moritz, Karen M., Perkins, Anthony V., Cuffe, James S. M.

“…Key points Maternal exposure to the stress hormone corticosterone is known to programme a range of sex specific disease outcomes in offspring. Sex differences…”
Get full text

Maternal Corticosterone Exposure in the Mouse Has Sex-Specific Effects on Placental Growth and mRNA Expression by Cuffe, J. S. M, O'Sullivan, L, Simmons, D. G, Anderson, S. T, Moritz, K. M

“…Maternal exposure to increased synthetic glucocorticoids (GC) during pregnancy is known to disturb fetal development and increase the risk of long-term…”
Get full text

Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring by Cuffe, J S M, Turton, E L, Akison, L K, Bielefeldt-Ohmann, H, Moritz, K M

“…Maternal stress can impair foetal development and program sex-specific disease outcomes in offspring through the actions of maternally produced…”
Get full text

Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet by Shrestha, Nirajan, Sleep, Simone L, Cuffe, James S M, Holland, Olivia J, McAinch, Andrew J, Dekker Nitert, Marloes, Hryciw, Deanne H

“…Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Changes in maternal gut microbiome have been implicated in the…”
Get more information

Maternal High Linoleic Acid Alters Placental Fatty Acid Composition by Shrestha, Nirajan, Holland, Olivia J, Kent, Nykola L, Perkins, Anthony V, McAinch, Andrew J, Cuffe, James S M, Hryciw, Deanne H

“…Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of linoleic acid (LA), an essential dietary n-6 polyunsaturated fatty…”
Get full text

Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression by Mangwiro, Yeukai T. M., Cuffe, James S. M., Mahizir, Dayana, Anevska, Kristina, Gravina, Sogand, Romano, Tania, Moritz, Karen M., Briffa, Jessica F., Wlodek, Mary E.

“…Key points Fetal growth is dependent on effective placental nutrient transportation, which is regulated by mammalian target of rapamycin (mTOR) complex 1…”
Get full text