Search Results - "Cuff, M."

Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections by Burton, Ross J, Albur, Mahableshwar, Eberl, Matthias, Cuff, Simone M

“…A substantial proportion of microbiological screening in diagnostic laboratories is due to suspected urinary tract infections (UTIs), yet approximately two…”
Get full text

CytoPy: An autonomous cytometry analysis framework by Burton, Ross J, Ahmed, Raya, Cuff, Simone M, Baker, Sarah, Artemiou, Andreas, Eberl, Matthias

“…Cytometry analysis has seen a considerable expansion in recent years in the maximum number of parameters that can be acquired in a single experiment. In…”
Get full text

Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis by Brook, Amy C., Jenkins, Robert H., Clayton, Aled, Kift-Morgan, Ann, Raby, Anne-Catherine, Shephard, Alex P., Mariotti, Barbara, Cuff, Simone M., Bazzoni, Flavia, Bowen, Timothy, Fraser, Donald J., Eberl, Matthias

“…Infection remains a major cause of morbidity, mortality and technique failure in patients with end stage kidney failure who receive peritoneal dialysis (PD)…”
Get full text

Structural Studies of ROK Fructokinase YdhR from Bacillus subtilis: Insights into Substrate Binding and Fructose Specificity by Nocek, B., Stein, A.J., Jedrzejczak, R., Cuff, M.E., Li, H., Volkart, L., Joachimiak, A.

“…The main pathway of bacterial sugar phosphorylation utilizes specific phosphoenolpyruvate phosphotransferase system (PTS) enzymes. In addition to the classic…”
Get full text

An investigation into the Sawtooth Effect in secondary school assessments in England by Cuff, Benjamin M. P., Meadows, Michelle, Black, Beth

“…The 'Sawtooth Effect' is where cohort performance on high-stakes assessments drops after assessment reform, and then improves over time as test familiarity…”
Get full text

A novel signal transduction protein: Combination of solute binding and tandem PAS‐like sensor domains in one polypeptide chain by Wu, R., Wilton, R., Cuff, M. E., Endres, M., Babnigg, G., Edirisinghe, J. N., Henry, C. S., Joachimiak, A., Schiffer, M., Pokkuluri, P. R.

“…We report the structural and biochemical characterization of a novel periplasmic ligand‐binding protein, Dret_0059, from Desulfohalobium retbaense DSM 5692, an…”
Get full text

CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue by Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A, Snelgrove, Robert J, Lacaze, Paul, Jacques, Laura C, Cuff, Simone M, Stanton, Richard J, Gallimore, Awen M, Hussell, Tracy, Wilkinson, Gavin W G, Ghazal, Peter, Taylor, Philip R, Humphreys, Ian R

“…CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200…”
Get full text

Crystal structure of the novel PaiB transcriptional regulator from Geobacillus stearothermophilus by Filippova, E. V., Brunzelle, J. S., Cuff, M. E., Li, H., Joachimiak, A., Anderson, W. F.

Get full text

The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis by Daly, K, Cuff, M A, Fung, F, Shirazi-Beechey, S P

“…The transition from normality to malignancy in colorectal cancer is characterized by alterations in the expression of genes associated with the maintenance of…”
Get more information

GeoWaVe: geometric median clustering with weighted voting for ensemble clustering of cytometry data by Burton, Ross J, Cuff, Simone M, Morgan, Matt P, Artemiou, Andreas, Eberl, Matthias

“…Abstract Motivation Clustering is an unsupervised method for identifying structure in unlabelled data. In the context of cytometry, it is typically used to…”
Get full text

The importance of butyrate transport to the regulation of gene expression in the colonic epithelium by Cuff, M A, Shirazi-Beechey, S P

“…Butyrate is a naturally occurring monocarboxylate, produced in the lumen of the colon by microbial fermentation of complex carbohydrates that escape digestion…”
Get more information

Conventional and unconventional T-cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients by Burton, Ross J, Raffray, Loïc, Moet, Linda M, Cuff, Simone M, White, Daniel A, Baker, Sarah E, Moser, Bernhard, O'Donnell, Valerie B, Ghazal, Peter, Morgan, Matt P, Artemiou, Andreas, Eberl, Matthias

“…Sepsis is characterized by a dysfunctional host response to infection culminating in life-threatening organ failure that requires complex patient management…”
Get full text

Control of neutrophil influx during peritonitis by transcriptional cross‐regulation of chemokine CXCL1 by IL‐17 and IFN‐γ by Catar, Rusan A, Chen, Lei, Cuff, Simone M, Kift‐Morgan, Ann, Eberl, Matthias, Kettritz, Ralph, Kamhieh‐Milz, Julian, Moll, Guido, Li, Qing, Zhao, Hongfan, Kawka, Edyta, Zickler, Daniel, Parekh, Gita, Davis, Paul, Fraser, Donald J, Dragun, Duska, Eckardt, Kai‐Uwe, Jörres, Achim, Witowski, Janusz

“…Neutrophil infiltration is a hallmark of peritoneal inflammation, but mechanisms regulating neutrophil recruitment in patients with peritoneal dialysis…”
Get full text

Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection by Cuff, S. M., Reeves, N., Lewis, E., Jones, E., Baker, S., Karategos, A., Morris, R., Torkington, J., Eberl, M.

“…Background The optimal treatment of colorectal cancer is surgical resection and primary anastomosis. Anastomotic leak can affect up to 20% of patients and…”
Get full text

Crystal structure of a functional unit from Octopus hemocyanin by Cuff, Marianne E., Miller, Karen I., van Holde, Kensal E., Hendrickson, Wayne A.

“…Hemocyanins are giant oxygen transport proteins found in many arthropods and molluscs. Freely dissolved in the hemolymph, they are multi-subunit proteins that…”
Get full text

Crystal structure of an acetyltransferase protein from Vibrio cholerae strain N16961 by Cuff, M.E., Li, H., Moy, S., Watson, J., Cipriani, A., Joachimiak, A.

Get full text

1.6 Å Crystal structure of a PA2721 protein from pseudomonas aeruginosa-A potential drug-resistance protein by Nocek, B., Cuff, M., Evdokimova, E., Edwards, A., Joachimiak, A., Savchenko, A.

Get full text

The human monocarboxylate transporter MCT1: gene structure and regulation by Cuff, M A, Shirazi-Beechey, S P

Get more information

The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T‐cell immunity by Twohig, Jason P., Marsden, Morgan, Cuff, Simone M., Ferdinand, John R., Gallimore, Awen M., Perks, William V., Al‐Shamkhani, Aymen, Humphreys, Ian R., Wang, Eddie C. Y.

“…ABSTRACT Death receptor 3 (DR3, TNFRSF25), the closest family relative to tumor necrosis factor receptor 1, promotes CD4+ T‐cell‐driven inflammatory disease…”
Get full text

Crystal structure of a predicted precorrin-8x methylmutase from Thermoplasma acidophilum by Cuff, M. E., Miller, D. J., Korolev, S., Xu, X., Anderson, W. F., Edwards, A., Joachimiak, A., Savchenko, A.

Get full text