Search Results - "Cuetos, Anibal"

Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched [beta]-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination by Cuetos, Aníbal, Garcia-Ramos, Marina, Fischereder, Eva-Maria, Diaz-Rodriguez, Alba, Grogan, Gideon, Gotor, Vicente, Kroutil, Wolfgang, Lavandera, Iván

“…Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require…”
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Asymmetric Synthesis of Primary and Secondary β‐Fluoro‐arylamines using Reductive Aminases from Fungi by González‐Martínez, Daniel, Cuetos, Aníbal, Sharma, Mahima, García‐Ramos, Marina, Lavandera, Iván, Gotor‐Fernández, Vicente, Grogan, Gideon

“…The synthesis of chiral amines is of central importance to pharmaceutical chemistry, and the inclusion of fluorine atoms in drug molecules can both increase…”
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Access to Enantiopure α-Alkyl-β-hydroxy Esters through Dynamic Kinetic Resolutions Employing Purified/Overexpressed Alcohol Dehydrogenases by Cuetos, Aníbal, Rioz-Martínez, Ana, Bisogno, Fabricio R., Grischek, Barbara, Lavandera, Iván, de Gonzalo, Gonzalo, Kroutil, Wolfgang, Gotor, Vicente

“…α‐Alkyl‐β‐hydroxy esters were obtained via dynamic kinetic resolution (DKR) employing purified or crude E. coli overexpressed alcohol dehydrogenases (ADHs)…”
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Dynamic Kinetic Resolution of α-Substituted β-Ketoesters Catalyzed by Baeyer-Villiger Monooxygenases: Access to Enantiopure α-Hydroxy Esters by Rioz-Martínez, Ana, Cuetos, Aníbal, Rodríguez, Cristina, de Gonzalo, Gonzalo, Lavandera, Iván, Fraaije, Marco W., Gotor, Vicente

“…BVMOs make a play: The dynamic kinetic resolution of racemic α‐alkyl‐β‐ketoesters was performed through a selective Baeyer–Villiger oxidation employing…”
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Polyphosphazenes as Tunable and Recyclable Supports To Immobilize Alcohol Dehydrogenases and Lipases: Synthesis, Catalytic Activity, and Recycling Efficiency by Cuetos, Aníbal, Valenzuela, María L, Lavandera, Iván, Gotor, Vicente, Carriedo, Gabino A

“…The polyphosphazene {NP[O2C12H7.5(NH2)0.5]} n , prepared by reacting {NP[O2C12H7.5(NO2)0.5]} with the Lalancette’s reagent, was used for attaching enzymes such…”
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Chemo- and Stereodivergent Preparation of Terminal Epoxides and Bromohydrins through One-Pot Biocatalysed Reactions: Access to Enantiopure Five- and Six-Membered N-Heterocycles by Bisogno, Fabricio R., Cuetos, Aníbal, Orden, Alejandro A., Kurina-Sanz, Marcela, Lavandera, Iván, Gotor, Vicente

“…Different enantiopure terminal epoxides or bromohydrins have chemoselectively been synthesised in one‐pot starting from the corresponding α‐bromo ketones…”
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Immobilized redox enzymatic catalysts: Baeyer–Villiger monooxygenases supported on polyphosphazenes by Cuetos, Aníbal, Rioz-Martínez, Ana, Valenzuela, María L., Lavandera, Iván, de Gonzalo, Gonzalo, Carriedo, Gabino A., Gotor, Vicente

“…[Display omitted] ► Several amino polyphosphazenes have been readily synthesized as enzymatic supports. ► Phenylacetone monooxygenase (PAMO) was successfully…”
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Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives by Cuetos, Aníbal, Lavandera, Iván, Gotor, Vicente

“…Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium…”
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Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination by Cuetos, Aníbal, García-Ramos, Marina, Fischereder, Eva-Maria, Díaz-Rodríguez, Alba, Grogan, Gideon, Gotor, Vicente, Kroutil, Wolfgang, Lavandera, Iván

“…Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require…”
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Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols by Cuetos, Aníbal, Bisogno, Fabricio R, Lavandera, Iván, Gotor, Vicente

“…A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities…”
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The Reactivity of α‐Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases by García‐Ramos, Marina, Cuetos, Aníbal, Kroutil, Wolfgang, Grogan, Gideon, Lavandera, Iván

“…A chemical method for the treatment of harmful halogenated compounds that has recently become of interest is the reductive dehalogenation of carbon‐halogen…”
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Multifunctional biocatalyst for conjugate reduction and reductive amination by Thorpe, Thomas W., Marshall, James R., Harawa, Vanessa, Ruscoe, Rebecca E., Cuetos, Anibal, Finnigan, James D., Angelastro, Antonio, Heath, Rachel S., Parmeggiani, Fabio, Charnock, Simon J., Howard, Roger M., Kumar, Rajesh, Daniels, David S. B., Grogan, Gideon, Turner, Nicholas J.

“…Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals 1 , yet their preparation often relies on low-efficiency multi-step synthesis 2…”
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The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides by Petchey, Mark, Cuetos, Anibal, Rowlinson, Benjamin, Dannevald, Stephanie, Frese, Amina, Sutton, Peter W., Lovelock, Sarah, Lloyd, Richard C., Fairlamb, Ian J. S., Grogan, Gideon

“…Amide bond formation is one of the most important reactions in pharmaceutical synthetic chemistry. The development of sustainable methods for amide bond…”
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Comparing the Catalytic and Structural Characteristics of a ‘Short’ Unspecific Peroxygenase (UPO) Expressed in Pichia pastoris and Escherichia coli by Robinson, Wendy X. Q., Mielke, Tamara, Melling, Benjamin, Cuetos, Anibal, Parkin, Alison, Unsworth, William P., Cartwright, Jared, Grogan, Gideon

“…Unspecific peroxygenases (UPOs) have emerged as valuable tools for the oxygenation of non‐activated carbon atoms, as they exhibit high turnovers, good…”
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Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms by Sharma, Mahima, Cuetos, Anibal, Willliams, Adam, González-Martínez, Daniel, Grogan, Gideon

“…The NADPH-dependent imine reductase from Ajellomyces dermatitidis (AdRedAm) catalyzes the reductive amination of certain ketones with amine donors supplied in…”
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S‐Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C‐Alkylation by McKean, Iain J. W., Sadler, Joanna C., Cuetos, Anibal, Frese, Amina, Humphreys, Luke D., Grogan, Gideon, Hoskisson, Paul A., Burley, Glenn A.

“…A tandem enzymatic strategy to enhance the scope of C‐alkylation of small molecules via the in situ formation of S‐adenosyl methionine (SAM) cofactor analogues…”
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Mutational Analysis of Linalool Dehydratase Isomerase Suggests That Alcohol and Alkene Transformations Are Catalyzed Using Noncovalent Mechanisms by Cuetos, Anibal, Iglesias-Fernández, Javier, Danesh-Azari, Hamid-Reza, Zukic, Erna, Dowle, Adam, Osuna, Sílvia, Grogan, Gideon

“…The interconversion of nonactivated alkenes and alcohols, catalyzed by (de)­hydratases, has great potential in biotechnology for the generation of fine and…”
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Structural Basis for Phospholyase Activity of a ClassIII Transaminase Homologue by Cuetos, Anibal, Steffen-Munsberg, Fabian, MangasSanchez, Juan, Frese, Amina, Bornscheuer, Uwe T, Hohne, Matthias, Grogan, Gideon

“…Pyridoxal-phosphate (PLP)-dependent enzymes catalyse a remarkable diversity of chemical reactions in nature. A1RDF1 from Arthrobacter aurescens TC1 is a fold…”
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Structural Basis for Phospholyase Activity of a Class III Transaminase Homologue by Cuetos, Anibal, Steffen-Munsberg, Fabian, Mangas Sanchez, Juan, Frese, Amina, Bornscheuer, Uwe T., Höhne, Matthias, Grogan, Gideon

“…Pyridoxal‐phosphate (PLP)‐dependent enzymes catalyse a remarkable diversity of chemical reactions in nature. A1RDF1 from Arthrobacter aurescens TC1 is a fold…”
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S‐Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C‐Alkylation by McKean, Iain J. W., Sadler, Joanna C., Cuetos, Anibal, Frese, Amina, Humphreys, Luke D., Grogan, Gideon, Hoskisson, Paul A., Burley, Glenn A.

“…A tandem enzymatic strategy to enhance the scope of C‐alkylation of small molecules via the in situ formation of S‐adenosyl methionine (SAM) cofactor analogues…”
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