Search Results - "Cuesta, Elena"

Chronic acidosis rewires cancer cell metabolism through PPARα signaling by Rolver, Michala G, Holland, Lya K K, Ponniah, Muthulakshmi, Prasad, Nanditha S, Yao, Jiayi, Schnipper, Julie, Kramer, Signe, Elingaard-Larsen, Line, Pedraz-Cuesta, Elena, Liu, Bin, Pardo, Luis A, Maeda, Kenji, Sandelin, Albin, Pedersen, Stine Falsig

“…The mechanisms linking tumor microenvironment acidosis to disease progression are not understood. Here, we used mammary, pancreatic, and colon cancer cells to…”
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A new carcharodontosaurian theropod (Dinosauria: Saurischia) from the Lower Cretaceous of Thailand by Chokchaloemwong, Duangsuda, Hattori, Soki, Cuesta, Elena, Jintasakul, Pratueng, Shibata, Masateru, Azuma, Yoichi

“…The isolated fossil remains of an allosauroid theropod from the Lower Cretaceous Khok Kruat Formation of Khorat, Thailand, are described in this study…”
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Avidity within the N‐terminal anchor drives α‐synuclein membrane interaction and insertion by Cholak, Ersoy, Bugge, Katrine, Khondker, Adree, Gauger, Kimmie, Pedraz‐Cuesta, Elena, Pedersen, Morten Enghave, Bucciarelli, Saskia, Vestergaard, Bente, Pedersen, Stine F., Rheinstädter, Maikel C., Langkilde, Annette Eva, Kragelund, Birthe B.

“…In the brain, α‐synuclein (aSN) partitions between free unbound cytosolic and membrane bound forms modulating both its physiological and pathological role and…”
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A diminutive perinate European Enantiornithes reveals an asynchronous ossification pattern in early birds by Knoll, Fabien, Chiappe, Luis M., Sanchez, Sophie, Garwood, Russell J., Edwards, Nicholas P., Wogelius, Roy A., Sellers, William I., Manning, Phillip L., Ortega, Francisco, Serrano, Francisco J., Marugán-Lobón, Jesús, Cuesta, Elena, Escaso, Fernando, Sanz, Jose Luis

“…Fossils of juvenile Mesozoic birds provide insight into the early evolution of avian development, however such fossils are rare. The analysis of the…”
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Editorial: Technological Frontiers in Dinosaur Science Mark a New Age of Opportunity for Early Career Researchers by Díez Díaz, Verónica, Cuesta, Elena, Vidal, Daniel, Belvedere, Matteo

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Recent Synthetic Approaches to 6,15-Iminoisoquino[3,2-b]3-benzazocine Compounds by Avendaño, Carmen, de la Cuesta, Elena

“…Saframycins, safracins, renieramycins, cribrostatins, and esteinascidins are 6,15‐iminoisoquino[3,2‐b]3‐benzazocine compounds that constitute the largest…”
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Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin by Hendus-Altenburger, Ruth, Wang, Xinru, Sjøgaard-Frich, Lise M., Pedraz-Cuesta, Elena, Sheftic, Sarah R., Bendsøe, Anne H., Page, Rebecca, Kragelund, Birthe B., Pedersen, Stine F., Peti, Wolfgang

“…Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na + /H + -exchanger…”
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Regulation of N-Myc downstream regulated gene 2 by bile acids by Langhi, Cédric, Pedraz-Cuesta, Elena, Donate, Yolanda, Marrero, Pedro F., Haro, Diego, Rodríguez, Joan C.

“…•Bile acid CDCA induces tumor suppressor NDRG2 expression in hepatocytes.•Induction of NDRG2 by bile acids requires FXR expression.•An intronic FXR-response…”
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Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides by Huck, Lena, González, Juan F, de la Cuesta, Elena, Menéndez, J Carlos

“…A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving…”
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Pyrazino[1,2- b]isoquinolines: Synthesis and study of their cytostatic and cytotoxic properties by Ortín, Irene, González, Juan Francisco, Cuesta, Elena de la, Manguan-García, Cristina, Perona, Rosario, Avendaño, Carmen

“…The in vitro antitumor potential of novel pyrazino[1,2- b]-isoquinoline-4-ones that contain a half portion of significant natural products was explored in…”
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The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 by Hendus-Altenburger, Ruth, Pedraz-Cuesta, Elena, Olesen, Christina W, Papaleo, Elena, Schnell, Jeff A, Hopper, Jonathan T S, Robinson, Carol V, Pedersen, Stine F, Kragelund, Birthe B

“…Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and…”
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The Vacuolar H + ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells by Flinck, Mette, Hagelund, Sofie, Gorbatenko, Andrej, Severin, Marc, Pedraz-Cuesta, Elena, Novak, Ivana, Stock, Christian, Pedersen, Stine Falsig

“…Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane…”
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Reactions promoted by [hydroxy(tosyloxy)iodo]benzene in pyrazino[1,2–b]isoquinolines by Ortín, Irene, González, Juan Francisco, Cuesta, Elena de la, Avendaño, Carmen

“…The hypervalent iodine reagent PhI(OH)OTs (HTIB) promoted oxidative demethylation of 1,4-hydroquinone methyl ethers to give quinones in a quantitative…”
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Cytotoxicity mechanisms of pyrazino[1,2- b]isoquinoline-4-ones and SAR studies by Ortín, Irene, González, Juan Francisco, Cuesta, Elena de la, Manguan-García, Cristina, Perona, Rosario, Avendaño, Carmen

“…The cytotoxicity showed by 1b, an interesting representant of the title compounds, for HT-29 human colon cancer cells (CI 50 value of 1.95 × 10 −7 M) has been…”
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Regulation of human class I alcohol dehydrogenases by bile acids by Langhi, Cédric, Pedraz-Cuesta, Elena, Haro, Diego, Marrero, Pedro F., Rodríguez, Joan C.

“…Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver. Because previous studies have…”
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Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di- N -Oxides Containing an Amino Acidic Side Chain by González, Juan F, Dea-Ayuela, María-Auxiliadora, Huck, Lena, Orduña, José María, Bolás-Fernández, Francisco, de la Cuesta, Elena, Haseen, Nazia, Mohammed, Ashraf Ali, Menéndez, J Carlos

“…We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These…”
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The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity by Hendus-Altenburger, Ruth, Vogensen, Jens, Pedersen, Emilie Skotte, Luchini, Alessandra, Araya-Secchi, Raul, Bendsoe, Anne H., Prasad, Nanditha Shyam, Prestel, Andreas, Cardenas, Marité, Pedraz-Cuesta, Elena, Arleth, Lise, Pedersen, Stine F., Kragelund, Birthe B.

“…Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly…”
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Multi-gram synthesis of precursors of bibrachial diaza-paracyclophanes. Complexes with Zn2+, Cu2+ and Co2+ ions by Avendaño, Carmen, Cuesta, Elena de la, Huck, Lena, Ortín, Irene, González, Juan Francisco

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Synthesis and cytotoxic activity of pyrazino[1,2- b]-isoquinolines, 1-(3-isoquinolyl)isoquinolines, and 6,15-iminoisoquino[3,2- b]-3-benzazocines by González, Juan Francisco, de la Cuesta, Elena, Avendaño, Carmen

“…A series of pyrazino[2,1- b]isoquinoline and 6,15-iminoisoquino[3,2- b]-3-benzazocine compounds related to renieramycins, cribrostatin 4, and phthalascidin was…”
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WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion by García, Esther, Ragazzini, Chiara, Yu, Xinzi, Cuesta-García, Elena, Bernardino de la Serna, Jorge, Zech, Tobias, Sarrió, David, Machesky, Laura M., Antón, Inés M.

“…Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), which allows their efficient dispersal during metastasis. Using…”
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