Search Results - "Cuende, Julia"

GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells by Gauthy, Emilie, Cuende, Julia, Stockis, Julie, Huygens, Caroline, Lethé, Bernard, Collet, Jean-François, Bommer, Guido, Coulie, Pierre G, Lucas, Sophie

“…GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent…”
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74 a-TIGIT mAb belrestotug in combination with anti-PD1 induces an immunocompetent tumor microenvironment (TME) by Cuende, Julia, Ma, Stephanie, Welsby, Iain, Rosewick, Nicolas, Wald, Noemie, Vezzu, Anais, Mercier, Marjorie, Tieppo, Paola, Claes, Bart, McGrath, Yvonne, Henau, Olivier De, Driessens, Gregory, Ceppi, Maurizio, Libouban, Marion

“…BackgroundT cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint inhibitor expressed mainly on NK and T cell populations. Antagonist a-TIGIT…”
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Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo by Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G, Lucas, Sophie

“…Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function contributes to cancer progression by inhibiting antitumor immune…”
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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies by Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…TIGIT is an immune checkpoint inhibitor expressed by effector CD4 and CD8 T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding…”
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Abstract 3240: EOS884448, a high affinity fully human antibody directed against TIGIT, mediates in vitro anti-tumor activity through multiples mechanisms of action involving activation of intratumor effector cells and depletion of regulatory T cells by Cuende, Julia, Rabolli, Virginie, Nyawouame, Florence, Mercier, Marjorie, Pappalardo, Angela, Garnero, Lucile, Dechanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a T cell co-inhibitory receptor recently described as a key checkpoint driving tumor cell…”
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Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile by Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+, NK, as well as by…”
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Abstract 4969: TIGIT pathway phenotyping sheds light on promising strategies to restore anti-tumor immunity by Wald, Noémie, Mercier, Marjorie, Cuende, Julia, Nyawouame, Florence, Prasad, Shruthi, Brouwer, Margreet, Houthuys, Erica, Marie-Cardine, Anne, Bagot, Martine, Driessens, Grégory, Bodo, Véronique, Hoofd, Catherine

“…Abstract TIGIT is a T cell co-inhibitory receptor recently described as a key checkpoint driving tumor cell immunosuppression. It is predominantly expressed on…”
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Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg by LEROY, XAVIER, Hoofd, Catherine, Cuende, Julia, Denies, Sofie, Rabolli, Virginie, Preillon, Julie, Lambolez, Florence, Prasad, Shruthi, Mercier, Marjorie, Nyawouame, Florence, Bodo, Véronique, Wald, Noémie, Driessens, Grégory, Detheux, Michel

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+ T cells, NK, as well…”
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Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors by Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion

“…Abstract T cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint inhibitor expressed mainly on NK and T cell populations which has demonstrated…”
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Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase by de Tudela, Miguel Veas-Perez, Delgado-Esteban, María, Cuende, Julia, Bolaños, Juan P, Almeida, Angeles

“…J. Neurochem. (2010) 113, 819-825. Neuroblastoma is a sympathetic nervous system tumour whose degree of malignancy, prognosis and therapy resistance has been…”
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GARP Is Regulated by miRNAs and Controls Latent TGF- beta 1 Production by Human Regulatory T Cells: e76186 by Gauthy, Emilie, Cuende, Julia, Stockis, Julie, Huygens, Caroline, Lethe, Bernard, Collet, Jean-Francois, Bommer, Guido, Coulie, Pierre G, Lucas, Sophie

“…GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent…”
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