Search Results - "Cuenda, A"

Phosphorylation of the discs large tumour suppressor protein controls its membrane localisation and enhances its susceptibility to HPV E6-induced degradation by MASSIMI, P, NARAYAN, N, CUENDA, A, BANKS, L

“…The Discs Large (Dlg) protein is intimately involved in regulating cell polarity and cell proliferation, and is targeted by the high-risk Human Papillomavirus…”
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Alternative ERK5 regulation by phosphorylation during the cell cycle by Iñesta-Vaquera, Francisco A., Campbell, David G., Tournier, Cathy, Gómez, Nestor, Lizcano, Jose M., Cuenda, A.

“…ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation, is activated selectively by dual phosphorylation in the TEY…”
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Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38) by Cuenda, Ana, Cohen, Philip, Buée-Scherrer, Valérie, Goedert, Michel

“…Stress‐activated protein kinase‐3 (SAPK3), a recently described MAP kinase family member with a widespread tissue distribution, was transfected into several…”
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The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor by Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J. C., Haegeman, G., Cohen, P., Fiers, W.

“…Tumour necrosis factor (TNF) is a pleiotropic cytokine, the activities of which include effects on gene expression, cell growth and cell death. The biological…”
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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 by Cuenda, Ana, Rouse, John, Doza, Yair N., Meier, Roger, Cohen, Philip, Gallagher, Timothy F., Young, Peter R., Lee, John C.

“…A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739–746]. We now show…”
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Use of kinase inhibitors to dissect signaling pathways by Cuenda, A, Alessi, D R

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Methods to assay stress-activated protein kinases by Cuenda, A

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p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient by Hazzalin, Catherine A., Cano, Eva, Cuenda, Ana, Barratt, Michael J., Cohen, Philip, Mahadevan, Louis C.

“…The ERK, JNK/SAPK and p38/RK MAP kinase subtypes (reviewed in [1]) are differentially activated in mammalian cells by various stimuli, which elicit induction…”
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Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress‐ and cytokine‐stimulated monocytes and epithelial cells by Cuenda, A., Alonso, G., Morrice, N., Jones, M., Meier, R., Cohen, P., Nebreda, A. R.

“…Two chromatographically distinct stress‐activated protein kinase kinases (SAPKKs) have been identified in several mammalian cells, termed SAPKK2 and SAPKK3,…”
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Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli by HAZZALIN, C. A, CUENDA, A, CANO, E, COHEN, P, MAHADEVAN, L. C

“…The ERK, JNK/SAPK and p38/RK MAP kinase subtypes are differentially activated by physiological, pharmacological and stress stimuli; all three subtypes are…”
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Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells by Doza, Yair N., Cuenda, Ana, Thomas, Gareth M., Cohen, Philip, Nebreda, Angel R.

“…A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that…”
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Mitogen-Activated Protein Kinase Kinase 4 (MKK4) by Cuenda, Ana

“…The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal…”
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BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo by Kuma, Yvonne, Sabio, Guadalupe, Bain, Jenny, Shpiro, Natalia, Márquez, Rodolfo, Cuenda, Ana

“…The compound BIRB796 inhibits the stress-activated protein kinases p38α and p38β and is undergoing clinical trials for the treatment of inflammatory diseases…”
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Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis by Cuenda, A, Cohen, P

“…The differentiation of C2C12 myoblasts to myotubes was found to be accompanied by a strong activation of p70 S6 kinase and the mitogen-activated protein kinase…”
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p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP by Sabio, Guadalupe, Arthur, James Simon Campbell, Kuma, Yvonne, Peggie, Mark, Carr, Julia, Murray-Tait, Vicky, Centeno, Francisco, Goedert, Michel, Morrice, Nicholas A, Cuenda, Ana

“…Activation of the p38 MAP kinase pathways is crucial for the adaptation of mammalian cells to changes in the osmolarity of the environment. Here we identify…”
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Glycogen phosphorolysis can form a metabolic shuttle to support Ca2+ uptake by sarcoplasmic reticulum membranes in skeletal muscle by Cuenda, A, Nogues, M, Gutiérrez-Merino, C, de Meis, L

“…In the presence of glycogen, ADP, phosphoglucomutase and hexokinase, the glycogen phosphorylase b activity associated to sarcoplasmic reticulum (SR) membranes…”
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Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38δ at Thr50 promotes microtubule assembly by Feijoo, Carmen, Campbell, David G., Jakes, Ross, Goedert, Michel, Cuenda, Ana

“…Phosphorylation regulates both normal and pathological Tau functioning. This microtubule-associated protein plays a role in the organization and integrity of…”
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The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells by Gould, G W, Cuenda, A, Thomson, F J, Cohen, P

“…The uptake of 2-deoxyglucose into KB cells was stimulated about 2-fold by interleukin-1 (IL1), anisomycin or insulin-like growth factor-1 (IGF1). Stimulation…”
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Ca2+ Uptake Coupled to Glycogen Phosphorolysis in the Glycogenolytic-Sarcoplasmic Reticulum Complex from Rat Skeletal Muscle by Nogues, M., Cuenda, A., Henao, F., Gutiérrez-Merino, C.

“…The glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle accumulates Ca upon stimulation of glycogen phosphorolysis in the absence of added…”
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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo by Alessi, D R, Cuenda, A, Cohen, P, Dudley, D T, Saltiel, A R

“…PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant…”
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