Delirium after Cardiac Surgery-A Narrative Review

Delirium after Cardiac Surgery-A Narrative Review

Postoperative delirium (POD) after cardiac surgery is a well-known phenomenon which carries a higher risk of morbidity and mortality. Multiple patient-specific risk factors and pathophysiologic mechanisms have been identified and therapies have been proposed to mitigate risk of delirium development...

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Bibliographic Details
Published in:Brain sciences Vol. 13; no. 12; p. 1682
Main Authors: Mattimore, Daniel, Fischl, Adrian, Christophides, Alexa, Cuenca, Jerry, Davidson, Steven, Jin, Zhaosheng, Bergese, Sergio
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-12-2023
Subjects:
Anticoagulants
Arterial lines
Atherosclerosis
Bivalirudin
Blood clots
Cardiac patients
cardiac surgery
cardiopulmonary bypass
Case reports
Coronary artery bypass
Delirium
Development and progression
Dexmedetomidine
Evidence-based medicine
Health aspects
Heart
Heart surgery
Hypothermia
Ischemia
Morbidity
Mortality
Patients
postoperative delirium
Ramelteon
Risk factors
Surgeons
Tetracycline
Tetracyclines
Therapeutic applications
Ultrasonic imaging
cardiopulmonary bypass
postoperative delirium
cardiac surgery
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Summary:Postoperative delirium (POD) after cardiac surgery is a well-known phenomenon which carries a higher risk of morbidity and mortality. Multiple patient-specific risk factors and pathophysiologic mechanisms have been identified and therapies have been proposed to mitigate risk of delirium development postoperatively. Notably, cardiac surgery frequently involves the use of an intraoperative cardiopulmonary bypass (CPB), which may contribute to the mechanisms responsible for POD. Despite our greater understanding of these causative factors, a substantial reduction in the incidence of POD remains high among cardiac surgical patients. Multiple therapeutic interventions have been implemented intraoperatively and postoperatively, many with conflicting results. This review article will highlight the incidence and impact of POD in cardiac surgical patients. It will describe some of the primary risk factors associated with POD, as well as anesthetic management and therapies postoperatively that may help to reduce delirium.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13121682