Search Results - "Cuello, A. C."

Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels by Navas Guimaraes, María Eugenia, Lopez-Blanco, Roi, Correa, Juan, Fernandez-Villamarin, Marcos, Bistué, María Beatriz, Martino-Adami, Pamela, Morelli, Laura, Kumar, Vijay, Wempe, Michael F, Cuello, A. C, Fernandez-Megia, Eduardo, Bruno, Martin A

“…The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although…”
Get full text

Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? by Ferretti, M T, Cuello, A C

“…The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the…”
Get more information

Transgenic mice as a model of pre-clinical Alzheimer's disease by Ferretti, M T, Partridge, V, Leon, W C, Canneva, F, Allard, S, Arvanitis, D N, Vercauteren, F, Houle, D, Ducatenzeiler, A, Klein, W L, Glabe, C G, Szyf, M, Cuello, A C

“…At diagnosis, Alzheimer's disease (AD) brains are extensively burdened with plaques and tangles and display a degree of synaptic failure most likely beyond…”
Get more information

Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status by Majdi, M, Ribeiro-da-Silva, A, Cuello, A.C

“…Abstract Age-related cognitive impairments are associated with structural and functional changes in the cerebral cortex. We have previously demonstrated in the…”
Get full text

The impact of Aβ-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer's disease-like transgenic mice by Hu, L, Wong, T.P, Côté, S.L, Bell, K.F.S, Cuello, A.C

“…A previous study in our laboratory, involving early stage, amyloid pathology in 8-month-old transgenic mice, demonstrated a selective loss of cholinergic…”
Get full text

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the β-amyloid peptide intracellularly in hippocampal and cortical neurons by Echeverria, V., Ducatenzeiler, A., Dowd, E., Jänne, J., Grant, S.M., Szyf, M., Wandosell, F., Avila, J., Grimm, H., Dunnett, S.B., Hartmann, T., Alhonen, L., Cuello, A.C.

“…The pathological significance of intracellular Aβ accumulation in vivo is not yet fully understood. To address this, we have studied transgenic rats expressing…”
Get full text

Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: synaptic pattern and age-related atrophy by Turrini, P, Casu, M.A, Wong, T.P, De Koninck, Y, Ribeiro-da-Silva, A, Cuello, A.C

“…This study addresses the issue of whether cholinergic varicosities in the cerebral cortex establish ‘classical synapses’ or whether they communicate with their…”
Get full text

High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB by Arvanitis, D.N, Ducatenzeiler, A, Ou, J.N, Grodstein, E, Andrews, S.D, Tendulkar, S.R, Ribeiro-da-Silva, A, Szyf, M, Cuello, A.C

“…The beta-amyloid peptide (Aβ) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic…”
Get full text

Revisiting the Cholinergic Hypothesis in Alzheimer’s Disease: Emerging Evidence from Translational and Clinical Research by Hampel, Harald, Mesulam, M.-M., Cuello, A. C., Khachaturian, A. S., Vergallo, A., Farlow, M. R., Snyder, P. J., Giacobini, E., Khachaturian, Z. S.

“…Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic innervation in the cerebral cortex of patients with Alzheimer’s…”
Get full text

Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology by Bell, K.F.S., de Kort, G.J.L., Steggerda, S., Shigemoto, R., Ribeiro-da-Silva, A., Cuello, A.C.

“…While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been…”
Get full text

Endogenous β-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells by Echeverria, V., Ducatenzeiler, A., Chen, C.H., Cuello, A.C.

“…Extracellular-regulated kinases play a fundamental role in several neuroplasticity processes. In order to test whether endogenous β-amyloid peptides play a…”
Get full text

Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury by Kolb, B, Côté, S, Ribeiro-da-Silva, A, Cuello, A.C

“…This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included…”
Get full text

BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology by Wilson, E N, Do Carmo, S, Iulita, M F, Hall, H, Ducatenzeiler, A, Marks, A R, Allard, S, Jia, D T, Windheim, J, Cuello, A C

“…Lithium is first-line therapy for bipolar affective disorder and has recently been shown to have protective effects in populations at risk for Alzheimer’s…”
Get full text

Preferential Synaptic Relationships between Substance P-Immunoreactive Boutons and Neurokinin 1 Receptor Sites in the Rat Spinal Cord by McLeod, A. L., Krause, J. E., Cuello, A. C., A. Ribeiro-Da-Silva

“…Substance P plays an important role in the transmission of pain-related information in the dorsal horn of the spinal cord. Recent immunocytochemical studies…”
Get full text

Afferents to the basal forebrain cholinergic cell area from pontomesencephalic--catecholamine, serotonin, and acetylcholine--neurons by Jones, B E, Cuello, A C

“…The afferent input to the basal forebrain cholinergic neurons from the pontomesencephalic tegmentum was examined by retrograde transport of wheatgerm…”
Get more information

Nerve Growth Factor-Induced Synaptogenesis and Hypertrophy of Cortical Cholinergic Terminals by Garofalo, Lorella, Alfredo Ribeiro-da-Silva, Cuello, A. Claudio

“…In this study light and EM quantitative analysis were used to examine whether exogenous nerve growth factor (NGF) could affect terminal fields and synaptic…”
Get full text

Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system--I. Forebrain by Pioro, E P, Cuello, A C

“…Nerve growth factor receptor, as recognized by the monoclonal antibody 192-IgG, was localized to multiple regions of the adult rat forebrain. Immunoreactive…”
Get more information

Coexistence of galanin-like immunoreactivity with catecholamines, 5- hydroxytryptamine, GABA and neuropeptides in the rat CNS by Melander, T, Hokfelt, T, Rokaeus, A, Cuello, AC, Oertel, WH, Verhofstad, A, Goldstein, M

“…The coexistence of galanin (GAL)-like immunoreactivity (LI) with markers for catecholamines, 5-hydroxytryptamine (5-HT), GABA, or some neuropeptides was mapped…”
Get full text

Early changes in neurons of the hippocampus and neocortex in transgenic rats expressing intracellular human a-beta by Lopez, E M, Bell, K F S, Ribeiro-da-Silva, A, Cuello, A C

“…Alzheimer's disease (AD) studies typically focus on the extracellular impact of the amyloid-beta (Abeta) protein, however recent findings also implicate…”
Get more information

Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing by Wong, T.P, Campbell, P.M, Ribeiro-da-Silva, A, Cuello, A.C

“…In this study, we have investigated the changes in the number of individual presynaptic boutons in the neocortex of rats and correlated them with cognitive…”
Get full text