Search Results - "Cudd, Timothy A."

Pharmacokinetics and safety of arginine supplementation in animals by Wu, Guoyao, Bazer, Fuller W, Cudd, Timothy A, Jobgen, Wenjuan S, Kim, Sung Woo, Lassala, Arantzatzu, Li, Peng, Matis, James H, Meininger, Cynthia J, Spencer, Thomas E

“…Anticipating the future use of arginine to enhance fetal and neonatal growth as well as to treat diabetes and obesity, we performed studies in pigs, rats, and…”
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Animal model systems for the study of alcohol teratology by Cudd, Timothy A

“…The incidence of fetal alcohol syndrome has not been declining even though alcohol has been established as a teratogen and significant efforts have been made…”
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The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent by Carugati, Megan, Goodlett, Charles R., Cudd, Timothy A., Washburn, Shannon E.

“…Individuals with fetal alcohol spectrum disorders (FASD) incur enduring brain damage and neurodevelopmental impairments from prenatal alcohol exposure (PAE)…”
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Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses by Lassala, Arantzatzu, Bazer, Fuller W, Cudd, Timothy A, Datta, Sujay, Keisler, Duane H, Satterfield, M Carey, Spencer, Thomas E, Wu, Guoyao

“…The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive technologies. This translates into a greater proportion of…”
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Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes by Lassala, Arantzatzu, Bazer, Fuller W, Cudd, Timothy A, Datta, Sujay, Keisler, Duane H, Satterfield, M Carey, Spencer, Thomas E, Wu, Guoyao

“…Intrauterine growth restriction (IUGR) is a major health problem worldwide that currently lacks an effective therapeutic solution. This study was conducted…”
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Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model by Parnell, Scott E., Ramadoss, Jayanth, Delp, Michael D., Ramsey, Michael W., Chen, Wei‐Jung A., West, James R., Cudd, Timothy A.

“…Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure causes fetal alcohol spectrum disorder (FASD) in children, but no study…”
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Maternal nutrition and fetal development by Wu, Guoyao, Bazer, Fuller W, Cudd, Timothy A, Meininger, Cynthia J, Spencer, Thomas E

“…Nutrition is the major intrauterine environmental factor that alters expression of the fetal genome and may have lifelong consequences. This phenomenon, termed…”
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Maternal and Neonatal Plasma MicroRNA Biomarkers for Fetal Alcohol Exposure in an Ovine Model by Balaraman, Sridevi, Lunde, E. Raine, Sawant, Onkar, Cudd, Timothy A., Washburn, Shannon E., Miranda, Rajesh C.

“…Background Plasma or circulating miRNAs (cirmiRNAs) have potential diagnostic value as biomarkers for a range of diseases. Based on observations that ethanol…”
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Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model by Sawant, Onkar B, Birch, Sharla M, Goodlett, Charles R, Cudd, Timothy A, Washburn, Shannon E

“…AbstractEarly detection of prenatal alcohol exposure is critical for designing and testing effectiveness of interventional therapeutics. Choline…”
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Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheep by Ramadoss, Jayanth, Hogan, Harry A., Given, Jon C., West, James R., Cudd, Timothy A.

“…Women who drink while pregnant are at a high risk of giving birth to children with neurodevelopmental disorders. Heavy consumption of alcohol during pregnancy…”
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Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma by Washburn, Shannon E, Sawant, Onkar B, Lunde, Emilie R, Wu, Guoyao, Cudd, Timothy A

“…Fetal alcohol syndrome (FAS) is a significant problem in human reproductive medicine. Maternal alcohol administration alters maternal amino acid homeostasis…”
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Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus by Lassala, Arantzatzu, Bazer, Fuller W, Cudd, Timothy A, Li, Peng, Li, Xilong, Satterfield, M Carey, Spencer, Thomas E, Wu, Guoyao

“…L-arginine administration may be useful for the treatment of intrauterine growth restriction, but concerns remain about effective precursors for administration…”
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Effects of all three trimester moderate binge alcohol exposure on the foetal hippocampal formation and olfactory bulb by Washburn, Shannon E., Ramadoss, Jayanth, Chen, Wei-Jung A., Cudd, Timothy A.

“…Abstract Objective: Pre-natal alcohol exposure results in injury to the hippocampus and olfactory bulb, but currently there is no consensus on the critical…”
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Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheep by Ramadoss, Jayanth, Wu, Guoyao, Cudd, Timothy A

“…Abstract Heavy drinking during pregnancy can result in fetal alcohol syndrome (FAS), of which, fetal and postnatal growth retardation and central nervous…”
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Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model by Sawant, Onkar B, Lunde, Emilie R, Washburn, Shannon E, Chen, Wei-Jung A, Goodlett, Charles R, Cudd, Timothy A

“…Abstract Studies in rat models of fetal alcohol spectrum disorders have indicated that the cerebellum is particularly vulnerable to ethanol-induced Purkinje…”
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Acute renal response to rapid onset respiratory acidosis by Ramadoss, Jayanth, Stewart, Randolph H, Cudd, Timothy A

“…Renal strong ion compensation to chronic respiratory acidosis has been established, but the nature of the response to acute respiratory acidosis is not well…”
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T-maze learning in weanling lambs by Johnson, Timothy B., Stanton, Mark E., Goodlett, Charles R., Cudd, Timothy A.

“…A major advantage of sheep models in experimental studies of neurodevelopmental disorders (e.g., with prenatal neurotoxicant exposure) is that the equivalent…”
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The role of cortisol in chronic binge alcohol-induced cerebellar injury: Ovine model by Washburn, Shannon E, Tress, Ursula, Lunde, Emilie R, Chen, Wei-Jung A, Cudd, Timothy A

“…Abstract Women who drink alcohol during pregnancy are at high risk of giving birth to children with neurodevelopmental disorders. Previous reports from our…”
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Temporal Vulnerability of Fetal Cerebellar Purkinje Cells to Chronic Binge Alcohol Exposure: Ovine Model by Ramadoss, Jayanth, Lunde, Emilie R., Chen, Wei-Jung A., West, James R., Cudd, Timothy A.

“…Background:  Human magnetic resonance imaging (MRI) and autopsy studies reveal abnormal cerebellar development in children who had been exposed to alcohol…”
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Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss by Ramadoss, Jayanth, Lunde, Emilie R, Ouyang, Nengtai, Chen, Wei-Jung A, Cudd, Timothy A

“…Ethanol is now considered the most common human teratogen. Educational campaigns have not reduced the incidence of ethanol-mediated teratogenesis, leading to a…”
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