Search Results - "Cuccarese, Michael F."

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy by Arlauckas, Sean P, Garris, Christopher S, Kohler, Rainer H, Kitaoka, Maya, Cuccarese, Michael F, Yang, Katherine S, Miller, Miles A, Carlson, Jonathan C, Freeman, Gordon J, Anthony, Robert M, Weissleder, Ralph, Pittet, Mikael J

“…Monoclonal antibodies (mAbs) targeting the immune checkpoint anti-programmed cell death protein 1 (aPD-1) have demonstrated impressive benefits for the…”
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Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging by Cuccarese, Michael F., Dubach, J. Matthew, Pfirschke, Christina, Engblom, Camilla, Garris, Christopher, Miller, Miles A., Pittet, Mikael J., Weissleder, Ralph

“…Involvement of the immune system in tumour progression is at the forefront of cancer research. Analysis of the tumour immune microenvironment has yielded a…”
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Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts by Miller, Miles A, Chandra, Ravi, Cuccarese, Michael F, Pfirschke, Christina, Engblom, Camilla, Stapleton, Shawn, Adhikary, Utsarga, Kohler, Rainer H, Mohan, James F, Pittet, Mikael J, Weissleder, Ralph

“…Efficient delivery of therapeutic nanoparticles (TNPs) to tumors is critical in improving efficacy, yet strategies that universally maximize tumoral targeting…”
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Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype by Sarkar, Biplab, Arlauckas, Sean P, Cuccarese, Michael F, Garris, Christopher S, Weissleder, Ralph, Rodell, Christopher B

“…Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune…”
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Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease by Miller, Miles A, Kim, Eunha, Cuccarese, Michael F, Plotkin, Alec L, Prytyskach, Mark, Kohler, Rainer H, Pittet, Mikael J, Weissleder, Ralph

“…The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells…”
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy by Rodell, Christopher B., Arlauckas, Sean P., Cuccarese, Michael F., Garris, Christopher S., Li, Ran, Ahmed, Maaz S., Kohler, Rainer H., Pittet, Mikael J., Weissleder, Ralph

“…Tumour-associated macrophages are abundant in many cancers, and often display an immune-suppressive M2-like phenotype that fosters tumour growth and promotes…”
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy by Rodell, Christopher B, Arlauckas, Sean P, Cuccarese, Michael F, Garris, Christopher S, Li, Ran, Ahmed, Maaz S, Kohler, Rainer H, Pittet, Mikael J, Weissleder, Ralph

“…Tumour-associated macrophages are abundant in many cancers, and often display an immune-suppressive M2-like phenotype that fosters tumour growth and promotes…”
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Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells by Pfirschke, Christina, Zilionis, Rapolas, Engblom, Camilla, Messemaker, Marius, Zou, Angela E, Rickelt, Steffen, Gort-Freitas, Nicolas A, Lin, Yunkang, Bill, Ruben, Siwicki, Marie, Gungabeesoon, Jeremy, Sprachman, Melissa M, Marquard, Angela N, Rodell, Christopher B, Cuccarese, Michael F, Quintana, Jeremy, Ahmed, Maaz S, Kohler, Rainer H, Savova, Virginia, Weissleder, Ralph, Klein, Allon M, Pittet, Mikael J

“…Macrophages often abound within tumors, express colony-stimulating factor 1 receptor (CSF1R), and are linked to adverse patient survival. Drugs blocking CSF1R…”
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A Novel Use of Gentamicin in the ROS-Mediated Sensitization of NCI-H460 Lung Cancer Cells to Various Anticancer Agents by Cuccarese, Michael F, Singh, Amit, Amiji, Mansoor, O’Doherty, George A

“…Aminoglycosides are broad-spectrum antibiotics that are used for the treatment of severe Gram-negative and Gram-positive bacterial infections. While…”
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Cryptocaryol Structure–Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4 by Cuccarese, Michael F, Wang, Yanping, Beuning, Penny J, O’Doherty, George A

“…The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor…”
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Application of the Wharton Rearrangement for the de novo Synthesis of Pyranosides with ido, manno, and colito Stereochemistry by Cuccarese, Michael F., Wang, Hua-Yu Leo, O'Doherty, George A.

“…A de novo asymmetric synthesis of α‐ido‐pyranosides, as well as several deoxy and amino variants, has been achieved. The procedure involves a…”
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Abstract 1888: Identification and optimization of novel small molecule modulators of immune checkpoint resistance with a unified representation space for genomic and chemical perturbations by Bhandari, Ashish, Cuccarese, Michael F., Fales, Kevin, Nadella, Kiran, Basso, Rebecca Sarto, Beshnova, Daria, Donnella, Hayley, Shamloo, Bahar, Cooper, Jacob, Haque, Imran, Alfa, Ron, Rinaldi, Jacob

“…Abstract Immune checkpoint inhibitors have revolutionized cancer treatment, producing a durable response consistent with immunologic memory in a subset of…”
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