Search Results - "Cuadros, Miguel A."
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Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina
Published in PloS one (29-08-2014)“…Inducible nitric oxide synthase (iNOS), which produce large amounts of nitric oxide (NO), is induced in macrophages and microglia in response to inflammatory…”
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Microglia and Microglia-Like Cells: Similar but Different
Published in Frontiers in cellular neuroscience (07-02-2022)“…Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and…”
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PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability
Published in Biochemical journal (11-12-2020)“…Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyze the transfer of ADP-ribose units from NAD+ to several target proteins involved in…”
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LPS-stimulated microglial cells promote ganglion cell death in organotypic cultures of quail embryo retina
Published in Frontiers in cellular neuroscience (15-03-2023)“…During development microglia colonize the central nervous system (CNS) and play an important role in programmed cell death, not only because of their ability…”
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Embryonic and postnatal development of microglial cells in the mouse retina
Published in Journal of comparative neurology (1911) (10-01-2008)“…Macrophage/microglial cells in the mouse retina during embryonic and postnatal development were studied by immunocytochemistry with Iba1, F4/80, anti‐CD45, and…”
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Onset of microglial entry into developing quail retina coincides with increased expression of active caspase-3 and is mediated by extracellular ATP and UDP
Published in PloS one (01-08-2017)“…Microglial cell precursors located in the area of the base of the pecten and the optic nerve head (BP/ONH) start to enter the retina of quail embryos at the…”
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Poly(ADP-ribose)polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H2O2
Published in PloS one (26-10-2017)“…Poly(ADP-ribose)polymerases (PARPs) are a family of NAD+ consuming enzymes that play a crucial role in many cellular processes, most clearly in maintaining…”
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Microglial Activation Promotes Cell Survival in Organotypic Cultures of Postnatal Mouse Retinal Explants
Published in PloS one (07-08-2015)“…The role of microglia during neurodegeneration remains controversial. We investigated whether microglial cells have a neurotoxic or neuroprotective function in…”
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Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases
Published in Biomolecules (Basel, Switzerland) (27-01-2022)“…Neurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident…”
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Microglial response to light-induced photoreceptor degeneration in the mouse retina
Published in Journal of comparative neurology (1911) (15-02-2010)“…The microglial response elicited by degeneration of retinal photoreceptor cells was characterized in BALB/c mice exposed to bright light for 7 hours and then…”
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Sortilin participates in light-dependent photoreceptor degeneration in vivo
Published in PloS one (27-04-2012)“…Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense…”
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Microglia and neuronal cell death
Published in Neuron glia biology (01-02-2011)“…Microglia, the brain's innate immune cell type, are cells of mesodermal origin that populate the central nervous system (CNS) during development…”
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Simultaneous cell death and upregulation of poly(ADP-ribose) polymerase-1 expression in early postnatal mouse retina
Published in Investigative ophthalmology & visual science (27-09-2011)“…Poly(ADP-ribose) polymerase (PARP)-1 is a nuclear enzyme that transfers ADP-ribose units (PAR polymer) to nuclear proteins and has been implicated in…”
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Upregulation of the secretory pathway Ca 2+ /Mn 2+ -ATPase isoform 1 in LPS-stimulated microglia and its involvement in Mn 2+ -induced Golgi fragmentation
Published in Glia (01-06-2024)“…Microglia play an important protective role in the healthy nervous tissue, being able to react to a variety of stimuli that induce different intracellular…”
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Distribution of intracellular Ca2+-ATPases in the mouse retina and their involvement in light-induced cone degeneration
Published in Biochimica et biophysica acta. Molecular cell research (01-01-2024)“…Calcium signalling is involved in many processes in mammalian retina, from development to mature functions and neurodegeneration. Although proteins involved in…”
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Upregulation of the secretory pathway Ca2+/Mn2+‐ATPase isoform 1 in LPS‐stimulated microglia and its involvement in Mn2+‐induced Golgi fragmentation
Published in Glia (01-06-2024)“…Microglia play an important protective role in the healthy nervous tissue, being able to react to a variety of stimuli that induce different intracellular…”
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The endoplasmic reticulum Ca2+‐ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis
Published in Glia (01-04-2021)“…Activation of microglia is an early immune response to damage in the brain. Although a key role for Ca2+ as trigger of microglial activation has been…”
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Microglial Phagocytosis During Embryonic and Postnatal Development
Published in Advances in neurobiology (2024)“…Microglia play decisive roles during the development of the central nervous system (CNS). Phagocytosis is one of the classical functions attributed to…”
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The endoplasmic reticulum Ca 2+ -ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis
Published in Glia (01-04-2021)“…Activation of microglia is an early immune response to damage in the brain. Although a key role for Ca as trigger of microglial activation has been considered,…”
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Radial migration of developing microglial cells in quail retina: A confocal microscopy study
Published in Glia (01-05-2004)“…Microglial cells spread within the nervous system by tangential and radial migration. The cellular mechanism of tangential migration of microglia has been…”
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