Search Results - "Csanaky, Iván L."

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC–MS/MS by Alnouti, Yazen, Csanaky, Iván L., Klaassen, Curtis D.

“…The differences among individual bile acids (BAs) in eliciting different physiological and pathological responses are largely unknown because of the lack of…”
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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy by Li, Feng, Lu, Jie, Cheng, Jie, Wang, Laiyou, Matsubara, Tsutomu, Csanaky, Iván L, Klaassen, Curtis D, Gonzalez, Frank J, Ma, Xiaochao

“…Rifampicin and isoniazid are often used together as a co-therapy to treat tuberculosis, but their combined use often leads to hepatoxicity in humans. Xiaochao…”
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Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice by Selwyn, Felcy Pavithra, Csanaky, Iván L, Zhang, Youcai, Klaassen, Curtis D

“…It is known that 1) elevated serum bile acids (BAs) are associated with decreased body weight, 2) elevated glucagon-like peptide-1 (GLP-1) levels can decrease…”
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Organic anion–transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2‐null mice by Csanaky, Iván L., Lu, Hong, Zhang, Youcai, Ogura, Kenichiro, Choudhuri, Supratim, Klaassen, Curtis D.

“…The organic anion–transporting polypeptide 1b family (Oatp1b2 in rodents and OATP1B1/1B3 in humans) is liver‐specific and transports various chemicals into the…”
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Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC–MS/MS by Huang, Jiangeng, Bathena, Sai Praneeth R., Csanaky, Iván L., Alnouti, Yazen

“…Sulfation is a major metabolic pathway involved in the elimination and detoxification of bile acids (BAs). Several lines of evidence are available to support…”
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Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice by Fu, Zidong Donna, Csanaky, Iván L, Klaassen, Curtis D

“…Aging is a physiological process characterized by progressive functional decline in various organs over time. To reveal possible molecular mechanisms of…”
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Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice by Zhang, Youcai, Lickteig, Andrew J., Liu, Jing, Csanaky, Iván L., Klaassen, Curtis D.

“…The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in bile acid (BA) homeostasis remains controversial. In this study, activation of Nrf2 was…”
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Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR by Lu, Hong, Choudhuri, Supratim, Ogura, Kenichiro, Csanaky, Iván L., Lei, Xiaohong, Cheng, Xingguo, Song, Pei-zhen, Klaassen, Curtis D.

“…The liver-specific importer organic anion transporting polypeptide 1b2 (Oatp1b2, Slco1b2, also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3…”
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Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance by Toth, Erica L., Clarke, John D., Csanaky, Iván L., Cherrington, Nathan J.

“…[Display omitted] The downregulation of hepatic uptake transporters, including those of the OATP family, are a well known consequence of nonalcoholic…”
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Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice by Csanaky, Iván L., Lickteig, Andrew J., Zhang, Youcai, Klaassen, Curtis D.

“…The Aryl hydrocarbon receptor (AhR) is primarily known as one of the xenosensors and regulators of drug-metabolizing genes. Bile acids (BAs) are synthesized in…”
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Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites by Scialis, Renato J, Aleksunes, Lauren M, Csanaky, Iván L, Klaassen, Curtis D, Manautou, José E

“…In the present work, in vivo transporter knockout (KO) mouse models were used to characterize the disposition of diclofenac (DCF) and its primary metabolites…”
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Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice by Lickteig, Andrew J, Zhang, Youcai, Klaassen, Curtis D, Csanaky, Iván L

“…Accumulation of bile acids (BAs) in hepatocytes has a role in liver disease and also in drug-induced liver injury. The constitutive androstane receptor (CAR)…”
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Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice by Csanaky, Iván L., Lickteig, Andrew J., Klaassen, Curtis D.

“…The effects of the most potent aryl hydrocarbon receptor (AhR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid (BA) homeostasis was examined in…”
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Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion by Zhang, Youcai, Lickteig, Andrew J., Csanaky, Iván L., Klaassen, Curtis D.

“…Fibrates are hypolipidemic drugs that act as activators of peroxisome proliferator-activated receptor α (PPARα). In both humans and rodents, females were…”
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Gender-divergent profile of bile acid homeostasis during aging of mice by Fu, Zidong Donna, Csanaky, Iván L, Klaassen, Curtis D

“…Aging is a physiological process with a progressive decline of adaptation and functional capacity of the body. Bile acids (BAs) have been recognized as…”
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Activation of Nrf2 decreases bile acid concentrations in livers of female mice by Liu, Jing, Lickteig, Andrew J., Zhang, Youcai, Csanaky, Iván L., Klaassen, Curtis D.

“…1. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of oxidative/electrophilic stress. Studies suggest a role of Nrf2 in regulating…”
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Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver by Lickteig, Andrew J, Csanaky, Iván L, Pratt-Hyatt, Matthew, Klaassen, Curtis D

“…Activation of Constitutive Androstane Receptor (CAR) protects against bile acid (BA)-induced liver injury. This study was performed to determine the effect of…”
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Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2–HNF-1α–FXR Signaling and Alters Systemic Bile Acid Homeostasis by Kazgan, Nevzat, Metukuri, Mallikarjuna R, Purushotham, Aparna, Lu, Jing, Rao, Anuradha, Lee, Sangkyu, Pratt–Hyatt, Matthew, Lickteig, Andrew, Csanaky, Iván L, Zhao, Yingming, Dawson, Paul A, Li, Xiaoling

“…Background & Aims Sirtuin 1 (SIRT1), the most conserved mammalian oxidized nicotinamide adenine dinucleotide–dependent protein deacetylase, is an important…”
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Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac by Scialis, Renato J, Csanaky, Iván L, Goedken, Michael J, Manautou, José E

“…Diclofenac (DCF) is a nonsteroidal anti-inflammatory drug commonly prescribed to reduce pain in acute and chronic inflammatory diseases. One of the main DCF…”
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Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective by Friesen, Chance S., Chan, Sherwin S., Wagner, Jonathan B., Hosey‐Cojocari, Chelsea, Csanaky, Iván L., Shakhnovich, Valentina

“…Nonalcoholic fatty liver disease (NAFLD) affects up to 70% of children with obesity and has become the number one etiology for liver transplant in the United…”
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