Search Results - "Cruz, Pedro"

The Neuromuscular Junction and Wide Heterogeneity of Congenital Myasthenic Syndromes by Rodríguez Cruz, Pedro M, Palace, Jacqueline, Beeson, David

“…Congenital myasthenic syndromes (CMS) are genetic disorders characterised by impaired neuromuscular transmission. This review provides an overview on CMS and…”
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Clinical Features and Diagnostic Usefulness of Antibodies to Clustered Acetylcholine Receptors in the Diagnosis of Seronegative Myasthenia Gravis by Rodríguez Cruz, Pedro M, Al-Hajjar, Michal, Huda, Saif, Jacobson, Leslie, Woodhall, Mark, Jayawant, Sandeep, Buckley, Camilla, Hilton-Jones, David, Beeson, David, Vincent, Angela, Leite, Maria Isabel, Palace, Jacqueline

“…Cell-based assays (CBAs) were shown to improve detection of acetylcholine receptor (AChR) antibodies in patients with myasthenia gravis (MG). Herein, we asked…”
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The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis by Rodríguez Cruz, Pedro M, Cossins, Judith, Beeson, David, Vincent, Angela

“…The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron nerve terminal and its muscle fiber that are responsible for converting…”
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Minimal clinically important differences in the Edmonton Symptom Assessment Scale in cancer patients: A prospective, multicenter study by Hui, David, Shamieh, Omar, Paiva, Carlos Eduardo, Perez‐Cruz, Pedro Emilio, Kwon, Jung Hye, Muckaden, Mary Ann, Park, Minjeong, Yennu, Sriram, Kang, Jung Hun, Bruera, Eduardo

“…BACKGROUND The Edmonton Symptom Assessment Scale (ESAS) is widely used for symptom assessment in clinical and research settings. A sensitivity‐specificity…”
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New insights into the classification and nomenclature of cortical GABAergic interneurons by DeFelipe, Javier, López-Cruz, Pedro L., Benavides-Piccione, Ruth, Bielza, Concha, Larrañaga, Pedro, Anderson, Stewart, Burkhalter, Andreas, Cauli, Bruno, Fairén, Alfonso, Feldmeyer, Dirk, Fishell, Gord, Fitzpatrick, David, Freund, Tamás F., González-Burgos, Guillermo, Hestrin, Shaul, Hill, Sean, Hof, Patrick R., Huang, Josh, Jones, Edward G., Kawaguchi, Yasuo, Kisvárday, Zoltán, Kubota, Yoshiyuki, Lewis, David A., Marín, Oscar, Markram, Henry, McBain, Chris J., Meyer, Hanno S., Monyer, Hannah, Nelson, Sacha B., Rockland, Kathleen, Rossier, Jean, Rubenstein, John L. R., Rudy, Bernardo, Scanziani, Massimo, Shepherd, Gordon M., Sherwood, Chet C., Staiger, Jochen F., Tamás, Gábor, Thomson, Alex, Wang, Yun, Yuste, Rafael, Ascoli, Giorgio A.

“…Key Points A feature-based classification and agreed-upon nomenclature of GABAergic interneurons of the cerebral cortex is much needed but currently lacking…”
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Crystallization-Enabled Henry Reactions: Stereoconvergent Construction of Fully Substituted [N]‑Asymmetric Centers by De Jesús Cruz, Pedro, Johnson, Jeffrey S.

“…Tetrasubstituted stereogenic carbon centers bearing a nitrogen substituent represent important motifs in medicinal chemistry and natural products; therefore,…”
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Catalytic, Asymmetric Michael-Aldol Annulations via a Stereodivergent/Stereoconvergent Path Operating under Curtin–Hammett Control by Giordano, Mitchell T., Kitzinger, Katelyn M., de Jesús Cruz, Pedro, Liu, Shubin, Johnson, Jeffrey S.

“…A bifunctional iminophosphorane (BIMP)-catalyzed method for the synthesis of densely functionalized cyclohexanols establishes five contiguous stereocenters…”
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Congenital myasthenic syndromes and the neuromuscular junction by Rodríguez Cruz, Pedro M, Palace, Jacqueline, Beeson, David

“…Congenital myasthenic syndromes (CMS) are a group of heterogeneous inherited disorders caused by mutations in genes encoding proteins essential for the…”
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Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies by Belaya, Katsiaryna, Rodríguez Cruz, Pedro M, Liu, Wei Wei, Maxwell, Susan, McGowan, Simon, Farrugia, Maria E, Petty, Richard, Walls, Timothy J, Sedghi, Maryam, Basiri, Keivan, Yue, Wyatt W, Sarkozy, Anna, Bertoli, Marta, Pitt, Matthew, Kennett, Robin, Schaefer, Andrew, Bushby, Kate, Parton, Matt, Lochmüller, Hanns, Palace, Jacqueline, Muntoni, Francesco, Beeson, David

“…Congenital myasthenic syndromes are inherited disorders that arise from impaired signal transmission at the neuromuscular junction. Mutations in at least 20…”
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Exergy analysis of alternative configurations of a system coproducing synthetic fuels and electricity via biomass gasification, Fischer-Tropsch synthesis and a combined-cycle scheme by Cruz, Pedro L., Iribarren, Diego, Dufour, Javier

“…•Simulation and exergy analysis of a base case and two alternative configurations.•Exergetic efficiencies of 23.7–26.7% at the system level.•Gasification and…”
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RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain by Kim, Jung In, Nakahama, Taisuke, Yamasaki, Ryuichiro, Costa Cruz, Pedro Henrique, Vongpipatana, Tuangtong, Inoue, Maal, Kanou, Nao, Xing, Yanfang, Todo, Hiroyuki, Shibuya, Toshiharu, Kato, Yuki, Kawahara, Yukio

“…Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and…”
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The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics by Cruz, Pedro M R, Mo, Huanbiao, McConathy, Walter J, Sabnis, Nirupama, Lacko, Andras G

“…While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the…”
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Doubly stereoconvergent crystallization enabled by asymmetric catalysis by de Jesús Cruz, Pedro, Cassels, William R, Chen, Chun-Hsing, Johnson, Jeffrey S

“…Synthetic methods that enable simultaneous control over multiple stereogenic centers are desirable for the efficient preparation of pharmaceutical compounds…”
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Exergy analysis of hydrogen production via biogas dry reforming by Cruz, Pedro L., Navas-Anguita, Zaira, Iribarren, Diego, Dufour, Javier

“…Among the alternative pathways for hydrogen production, the use of biogas from organic waste via dry reforming of methane (DRM), water gas shift reaction and…”
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Nature's contributions to people in mountains: A review by Martín-López, Berta, Leister, Ines, Lorenzo Cruz, Pedro, Palomo, Ignacio, Grêt-Regamey, Adrienne, Harrison, Paula A, Lavorel, Sandra, Locatelli, Bruno, Luque, Sandra, Walz, Ariane

“…Mountains play a key role in the provision of nature's contributions to people (NCP) worldwide that support societies' quality of life. Simultaneously,…”
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A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing by Costa Cruz, Pedro Henrique, Kato, Yuki, Nakahama, Taisuke, Shibuya, Toshiharu, Kawahara, Yukio

“…Adenosine-to-inosine RNA editing is an essential post-transcriptional modification catalyzed by adenosine deaminase acting on RNA (ADAR)1 and ADAR2 in mammals…”
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Simulation and life cycle assessment of synthetic fuels produced via biogas dry reforming and Fischer-Tropsch synthesis by Navas-Anguita, Zaira, Cruz, Pedro L., Martín-Gamboa, Mario, Iribarren, Diego, Dufour, Javier

“…•Simulation of a process coproducing synthetic fuels and electricity from biogas.•Implementation of a detailed reaction model of biogas dry reforming.•Process…”
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Stereodivergent Nucleophilic Additions to Racemic β‑Oxo Acid Derivatives: Fast Addition Outcompetes Stereoconvergence in the Archetypal Configurationally Unstable Electrophile by De Jesús Cruz, Pedro, Crawford, Evan T, Liu, Shubin, Johnson, Jeffrey S

“…Additions of carbon nucleophiles to racemic α-stereogenic β-oxo acid derivatives that deliver enantiomerically enriched tertiary alcohols are valuable, but…”
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Attitude Uncertainty Analysis of a Three-Vehicle Constrained Formation by Cruz, Pedro, Batista, Pedro

“…The uncertainty analysis of attitude estimates enables the comparison between different methods, and, thus, it is important for practical applications. This…”
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Personalized symptom goals and response in patients with advanced cancer by Hui, David, Park, Minjeong, Shamieh, Omar, Paiva, Carlos Eduardo, Perez‐Cruz, Pedro Emilio, Muckaden, Mary Ann, Bruera, Eduardo

“…BACKGROUND Improving symptoms is a major goal of cancer medicine; however, symptom response is often based on group differences and not individualized. In the…”
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