The insular cortex, autonomic asymmetry and cardiovascular control: looking at the right side of stroke

The insular cortex, autonomic asymmetry and cardiovascular control: looking at the right side of stroke

Purpose Evidence from animal and human studies demonstrates that cortical regions play a key role in autonomic modulation with a differential role for some brain regions located in the left and right brain hemispheres. Known as autonomic asymmetry, this phenomenon has been demonstrated by clinical o...

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Bibliographic Details
Published in:Clinical autonomic research Vol. 34; no. 6; pp. 549 - 560
Main Authors: Fontes, Marco Antônio Peliky, dos Santos Machado, Liliane Ramos, Viana, Ana Clara Rocha, Cruz, Matheus Henrique, Nogueira, Ícaro Santos, Oliveira, Marcela Gondim Lima, Neves, Christiane Braga, Godoy, Ana Caroline Ventris, Henderson, Luke A., Macefield, Vaughan G.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2024
Springer Nature B.V
Subjects:
Animal models
Asymmetry
Autonomic nervous system
Cardiology
Cardiovascular system
Cerebral hemispheres
Cortex (insular)
Diabetes
Endocrinology
Gastroenterology
Hemispheric laterality
Medicine
Medicine & Public Health
Neuroimaging
Neurology
Ophthalmology
Review Article
Stroke
Sympathetic nerves
Dorsomedial hypothalamus
Stroke
Asymmetry
Cardiovascular
Insular cortex
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Summary:Purpose Evidence from animal and human studies demonstrates that cortical regions play a key role in autonomic modulation with a differential role for some brain regions located in the left and right brain hemispheres. Known as autonomic asymmetry, this phenomenon has been demonstrated by clinical observations, by experimental models, and currently by combined neuroimaging and direct recordings of sympathetic nerve activity. Previous studies report peculiar autonomic-mediated cardiovascular alterations following unilateral damage to the left or right insula, a multifunctional key cortical region involved in emotional processing linked to autonomic cardiovascular control and featuring asymmetric characteristics. Methods Based on clinical studies reporting specific damage to the insular cortex, this review aims to provide an overview of the prognostic significance of unilateral (left or right hemisphere) post-insular stroke cardiac alterations. In addition, we review experimental data aiming to unravel the central mechanisms involved in post-insular stroke cardiovascular complications. Results and Conclusion Current clinical and experimental data suggest that stroke of the right insula  can present a worse cardiovascular prognosis.
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ISSN:0959-9851
1619-1560
1619-1560
DOI:10.1007/s10286-024-01066-9