Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats

Abstract AIM To compare the amount of cardioprotection induced by a single exercise session with those achieved after an 8-week aerobic exercise training following ischemia reperfusion injury in rats. METHODS Twenty-five male Wistar rats (250-300g) were assigned into a group submitted to physical tr...

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Bibliographic Details
Published in:	Motriz : Revista de Educação Física. Unesp Vol. 23; no. spe
Main Authors:	Borges, Juliana Pereira, França, Guilherme de Oliveira, Cruz, Mariana Delgado, Lanza, Rômulo, Nascimento, Alessandro Rodrigues do, Lessa, Marcos Adriano
Format:	Journal Article
Language:	English
Published:	Universidade Estadual Paulista 2017 Universidade Estadual Paulista (UNESP)
Subjects:	aerobic exercise training ischemia and reperfusion Langendorff SPORT SCIENCES aerobic exercise training ischemia and reperfusion Langendorff
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Summary:	Abstract AIM To compare the amount of cardioprotection induced by a single exercise session with those achieved after an 8-week aerobic exercise training following ischemia reperfusion injury in rats. METHODS Twenty-five male Wistar rats (250-300g) were assigned into a group submitted to physical training (TR; n=12) or a single maximal exercise session (EXE; n=13). Following sedentarism or physical training (8 weeks, 5 sessions/wk, 1h/session at 70% of maximal speed) both groups performed a maximal exercise test. Then, groups were submitted to ischemia reperfusion injury (30 min/1h) through an isolated heart protocol, in which left ventricle developed pressure was measured. RESULTS The TR group presented greater maximal oxygen consumption compared to the EXE group (77.25±20.41 vs 41.32±25.86 ml/Kg/min; P=0.003). Regarding left ventricle developed pressure, no differences were detected between groups at baseline (TR: 89.78±24.40 vs EXE: 81.37±31.84 mmHg; P=0.48). However, after reperfusion, the TR group presented superior intraventricular pressure than EXE group (37.94±18.34 vs 21.59±13.67 mmHg; P=0.03). CONCLUSION Eight-week aerobic training induced greater cardioprotection against ischemia reperfusion injury in rats compared to a single exercise session, due to an increased cardiac function. This suggests that exercise-induced cardioprotection is a multifactorial process that may involve different mediators according to the exercise duration.
ISSN:	1980-6574 1980-6574
DOI:	10.1590/s1980-6574201700si0011