Search Results - "Cruz, Josefa"

Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland by Cruz, Josefa, Martín, David, Franch-Marro, Xavier

“…Understanding the mechanisms that determine final body size of animals is a central question in biology. In animals with determinate growth, such as mammals or…”
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Author Correction: FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2 by Cruz, Josefa, Bota-Rabassedas, Neus, Franch-Marro, Xavier

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TGFß/activin-dependent activation of Torso controls the timing of the metamorphic transition in the red flour beetle Tribolium castaneum by Chafino, Sílvia, Salvia, Roser, Cruz, Josefa, Martín, David, Franch-Marro, Xavier

“…Understanding the mechanisms governing body size attainment during animal development is of paramount importance in biology. In insects, a crucial phase in…”
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates by Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G

“…Antibody-drug conjugates (ADC) are designed to selectively bind to tumor antigens via the antibody and release their cytotoxic payload upon internalization…”
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FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2 by Cruz, Josefa, Bota-Rabassedas, Neus, Franch-Marro, Xavier

“…How several signaling pathways are coordinated to generate complex organs through regulation of tissue growth and patterning is a fundamental question in…”
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Nuclear receptors EcR-A/RXR and HR3 control early embryogenesis in the short-germ hemimetabolous insect Blattella germanica by Cruz, Josefa, Maestro, Oscar, Franch-Marro, Xavier, Martín, David

“…The role of steroid hormone signaling during insect post-embryonic development has been extensively characterized. However, its function during embryonic…”
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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates by Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S

“…Cytotoxic pyrrolobenzodiazepine (PBD)-dimer molecules are frequently utilized as payloads for antibody–drug conjugates (ADCs), and many examples are currently…”
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A critical role of the nuclear receptor HR3 in regulation of gonadotrophic cycles of the mosquito Aedes aegypti by Mane-Padros, Daniel, Cruz, Josefa, Cheng, Andrew, Raikhel, Alexander S

“…The orphan nuclear receptor HR3 is essential for developmental switches during insect development and metamorphosis regulated by 20-hydroxyecdysone (20E)…”
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Functions of the ecdysone receptor isoform-A in the hemimetabolous insect Blattella germanica revealed by systemic RNAi in vivo by Cruz, Josefa, Mané-Padrós, Daniel, Bellés, Xavier, Martín, David

“…The molecular basis of ecdysteroid function during development has been analyzed in detail in holometabolous insects, especially in Drosophila melanogaster,…”
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The hormonal pathway controlling cell death during metamorphosis in a hemimetabolous insect by Mané-Padrós, Daniel, Cruz, Josefa, Vilaplana, Lluisa, Nieva, Claudia, Ureña, Enric, Bellés, Xavier, Martín, David

“…Metamorphosis in holometabolous insects is mainly based on the destruction of larval tissues. Intensive research in Drosophila melanogaster, a model of…”
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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay by Fourie-O'Donohue, Aimee, Chu, Phillip Y, Dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C, Sawyer, William S, Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H, Sadowsky, Jack, Dragovich, Peter S, Liu, Yichin, Kozak, Katherine R

“…For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several…”
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The nuclear hormone receptor BgE75 links molting and developmental progression in the direct-developing insect Blattella germanica by Mané-Padrós, Daniel, Cruz, Josefa, Vilaplana, Lluïsa, Pascual, Nuria, Bellés, Xavier, Martín, David

“…Ecdysteroid hormones regulate key developmental processes throughout the life cycle of insects. 20-Hydroxyecdysone (20E) acts upon binding to a heterodimeric…”
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Specification of Differentiated Adult Progenitors via Inhibition of Endocycle Entry in the Drosophila Trachea by Djabrayan, Nareg J.-V., Cruz, Josefa, de Miguel, Cristina, Franch-Marro, Xavier, Casanova, Jordi

“…A population of Drosophila adult tracheal progenitor cells arises from differentiated cells of the larval main trachea that retain the ability to reenter the…”
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Nuclear receptor BgFTZ‐F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica by Cruz, Josefa, Nieva, Claudia, Mané‐Padrós, Daniel, Martín, David, Bellés, Xavier

“…Postembryonic development of holometabolous and hemimetabolous insects occurs through successive molts triggered by 20‐hydroxyecdysone (20E). The molecular…”
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Antibody Persistence 3 Years after Immunization of Adolescents with Quadrivalent Meningococcal Conjugate Vaccine by Vu, David M., Welsch, Jo Anne, Zuno-Mitchell, Patricia, Dela Cruz, Josefa V., Granoff, Dan M.

“…BackgroundA quadrivalent meningococcal conjugate vaccine (MCV-4) is recommended for United States teenagers. The duration of protective immunity is unknown. We…”
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Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents by Kozak, Katherine R, Tsai, Siao Ping, Fourie-O’Donohue, Aimee, dela Cruz Chuh, Josefa, Roth, Leslie, Cook, Ryan, Chan, Elton, Chan, Pamela, Darwish, Martine, Ohri, Rachana, Raab, Helga, Zhang, Crystal, Lin, Kedan, Wong, Wai Lee T

“…Antibody–drug conjugates (ADCs) are target-specific anticancer agents consisting of cytotoxic drugs covalently linked to a monoclonal antibody. The number of…”
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Differential expression of two RXR/ultraspiracle isoforms during the life cycle of the hemimetabolous insect Blattella germanica (Dictyoptera, Blattellidae) by Maestro, Oscar, Cruz, Josefa, Pascual, Núria, Martín, David, Bellés, Xavier

“…In insects, the molecular basis of ecdysteroid action has been analysed in great detail in flies and moths, but rarely in primitive orders. Using the primitive…”
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Forkhead transcription factors regulate mosquito reproduction by Hansen, Immo A., Sieglaff, Douglas H., Munro, James B., Shiao, Shin-Hong, Cruz, Josefa, Lee, Iris W., Heraty, John M., Raikhel, Alexander S.

“…Forkhead-box (Fox) genes encode a family of transcription factors defined by a ‘winged helix’ DNA-binding domain. In this study we aimed to identify Fox…”
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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy by Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu

“…Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous…”
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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties by Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu

“…The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target…”
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