Search Results - "Cruz, Jorddy N"

Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom by Rego, Cristina M. A., Francisco, Aleff F., Boeno, Charles N., Paloschi, Mauro V., Lopes, Jéssica A., Silva, Milena D. S., Santana, Hallison M., Serrath, Suzanne N., Rodrigues, Jaína E., Lemos, Caleb T. L., Dutra, Ricardo S. S., da Cruz, Jorddy N., dos Santos, Cleydson Breno R., da S. Setúbal, Sulamita, Fontes, Marcos R. M., Soares, Andreimar M., Pires, Weverson L., Zuliani, Juliana P.

“…Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake species, Crotalus durissus terrificus , stimulates platelet aggregation by…”
Get full text

Discovery of α-amylase and α-glucosidase dual inhibitors from NPASS database for management of Type 2 Diabetes Mellitus: A chemoinformatic approach by Ndarawit, Wilberforce, Ochieng, Charles Otieno, Angwenyi, David, Cruz, Jorddy N., Santos, Cleydson B. R., Kimani, Njogu M.

“…Postprandial hyperglycemia, typical manifestation of Type 2 Diabetes Mellitus (T 2 DM), is associated with notable global morbidity and mortality. Preventing…”
Get full text

Green Surfactants (Biosurfactants): A Petroleum-Free Substitute for SustainabilityComparison, Applications, Market, and Future Prospects by Nagtode, Vaishnavi S., Cardoza, Clive, Yasin, Haya Khader Ahmad, Mali, Suraj N., Tambe, Srushti M., Roy, Pritish, Singh, Kartikeya, Goel, Antriksh, Amin, Purnima D., Thorat, Bapu R., Cruz, Jorddy N., Pratap, Amit P.

“…Surfactants are a group of amphiphilic molecules (i.e., having both hydrophobic and hydrophilic domains) that are a vital part of nearly every contemporary…”
Get full text

Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach by Silva, Luciane B, Ferreira, Elenilze F B, Maryam, Espejo-Román, José M, Costa, Glauber V, Cruz, Josiane V, Kimani, Njogu M, Costa, Josivan S, Bittencourt, José A H M, Cruz, Jorddy N, Campos, Joaquín M, Santos, Cleydson B R

“…Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer's disease (AD). Its excessive activity causes several neuronal…”
Get full text

Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches by Santos, Kelton L B Dos, Cruz, Jorddy N, Silva, Luciane B, Ramos, Ryan S, Neto, Moysés F A, Lobato, Cleison C, Ota, Sirlene S B, Leite, Franco H A, Borges, Rosivaldo S, Silva, Carlos H T P da, Campos, Joaquín M, Santos, Cleydson B R

“…Adenosine Receptor Type 2A (A AR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for…”
Get full text

Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2 by Bastos, Ruan S, de Lima, Lúcio R, Neto, Moysés F A, Maryam, Yousaf, Numan, Cruz, Jorddy N, Campos, Joaquín M, Kimani, Njogu M, Ramos, Ryan S, Santos, Cleydson B R

“…When an epidemic started in the Chinese city of Wuhan in December 2019, coronavirus was identified as the cause. Infection by the virus occurs through the…”
Get full text

Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13 by Cruz, Jorddy N., Costa, José F. S., Khayat, André S., Kuca, Kamil, Barros, Carlos A. L., Neto, A. M. J. C.

“…In this work, the binding mechanism of new Polyketide Synthase 13 (Pks13) inhibitors has been studied through molecular dynamics simulation and free energy…”
Get full text

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies by de Almeida, Raquel B M, Barbosa, Deyse B, do Bomfim, Mayra R, Amparo, Jéssika A O, Andrade, Bruno S, Costa, Silvia L, Campos, Joaquín M, Cruz, Jorddy N, Santos, Cleydson B R, Leite, Franco H A, Botura, Mariana B

“…The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic…”
Get full text

Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach by Leão, Rozires P, Cruz, Josiane V, da Costa, Glauber V, Cruz, Jorddy N, Ferreira, Elenilze F B, Silva, Raí C, de Lima, Lúcio R, Borges, Rosivaldo S, Dos Santos, Gabriela B, Santos, Cleydson B R

“…The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-inflammatory activity. The selective cyclooxygenase-2 (COX-2)…”
Get full text

Rational Approach toward COVID-19's Main Protease Inhibitors: A Hierarchical Biochemoinformatics Analysis by Bastos, Ruan S, de Aguiar, Christiane P O, Cruz, Jorddy N, Ramos, Ryan S, Kimani, Njogu M, de Souza, João S N, Chaves, Mariana H, de Freitas, Humberto F, Pita, Samuel S R, Santos, Cleydson B R Dos

“…This study investigated the potential of selected compounds as inhibitors of SARS-CoV-2 M through pharmacokinetic and toxicological analyses, molecular…”
Get full text

Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches by Araújo, Pedro H F, Ramos, Ryan S, da Cruz, Jorddy N, Silva, Sebastião G, Ferreira, Elenilze F B, de Lima, Lúcio R, Macêdo, Williams J C, Espejo-Román, José M, Campos, Joaquín M, Santos, Cleydson B R

“…Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective…”
Get full text

Lycopene supplementation promoted increased survival and decreased parasitemia in mice with severe malaria: comparison with N-acetylcysteine by Varela, Everton Luiz P, Gomes, Antônio Rafael Q, Santos, Aline S B Dos, Cruz, Jorddy N DA, Carvalho, Eliete P DE, Prazeres, Benedito Antônio P Dos, Dolabela, Maria Fani, Percario, Sandro

“…Oxidative stress is involved in the pathogenesis of malaria, causing anemia, respiratory complications, and cerebral malaria. To mitigate oxidative stress, we…”
Get full text

Acidulated Soapstock as a Carbon Source for the Production of Mannosylerythritol Lipids by Pseudozyma antarctica ATCC 2706 by Dombe, Sushil S., Mali, Suraj N., Jadhav, Jagruti V., Kale, Sandeep B., Pratap, Amit P., Cruz, Jorddy N.

“…Acid oil produced from the acidulation of soapstock was investigated as a feedstock for producing a glycolipid biosurfactant, manosylerithritol lipid (MEL), by…”
Get full text

In Silico Study to Identify New Antituberculosis Molecules from Natural Sources by Hierarchical Virtual Screening and Molecular Dynamics Simulations by Pinto, Vinícius de S, Araújo, Janay S C, Silva, Rai C, da Costa, Glauber V, Cruz, Jorddy N, De A Neto, Moysés F, Campos, Joaquín M, Santos, Cleydson B R, Leite, Franco H A, Junior, Manoelito C S

“…Tuberculosis (TB) is an infection caused by , responsible for 1.5 million documented deaths in 2016. The increase in reported cases of resistance to the main…”
Get full text

A review on mycogenic metallic nanoparticles and their potential role as antioxidant, antibiofilm and quorum quenching agents by Cruz, Jorddy N., Muzammil, Saima, Ashraf, Asma, Ijaz, Muhammad Umar, Siddique, Muhammad Hussnain, Abbas, Rasti, Sadia, Maimona, Saba, Hayat, Sumreen, Lima, Rafael Rodrigues

“…The emergence of antimicrobial resistance among biofilm forming pathogens aimed to search for the efficient and novel alternative strategies. Metallic…”
Get full text

Development of Potential Multi-Target Inhibitors for Human Cholinesterases and Beta-Secretase 1: A Computational Approach by Barbosa, Deyse B, do Bomfim, Mayra R, de Oliveira, Tiago A, da Silva, Alisson M, Taranto, Alex G, Cruz, Jorddy N, de Carvalho, Paulo B, Campos, Joaquín M, Santos, Cleydson B R, Leite, Franco H A

“…Alzheimer's disease causes chronic neurodegeneration and is the leading cause of dementia in the world. The causes of this disease are not fully understood but…”
Get full text

Hierarchical Virtual Screening of Potential New Antibiotics from Polyoxygenated Dibenzofurans against Staphylococcus aureus Strains by Oliveira, Lana P. S., Lima, Lúcio R., Silva, Luciane B., Cruz, Jorddy N., Ramos, Ryan S., Lima, Luciana S., Cardoso, Francy M. N., Silva, Aderaldo V., Rodrigues, Dália P., Rodrigues, Gabriela S., Proietti-Junior, Aldo A., dos Santos, Gabriela B., Campos, Joaquín M., Santos, Cleydson B. R.

“…Staphylococcus aureus is a microorganism with high morbidity and mortality due to antibiotic-resistant strains, making the search for new therapeutic options…”
Get full text

Methoxylated flavonols from Vellozia dasypus Seub ethyl acetate active myeloperoxidase extract: in vitro and in silico assays by Almeida, Verônica M., Dias, Êuder R., Souza, Bruno C., Cruz, Jorddy N., Santos, Cleydson B. R., Leite, Franco H. A., Queiroz, Raphael F., Branco, Alexsandro

“…This study aimed to evaluate the effect of a methoxylated fraction from Vellozia dasypus Seub on myeloperoxidase (MPO)-chlorinating activity and subsequent in…”
Get full text

Novel chalcones derivatives with potential antineoplastic activity investigated by docking and molecular dynamics simulations by Neto, Raimundo de A. M., Santos, Cleydson B. R., Henriques, Shayanne V. C., Machado, Letícia de O., Cruz, Jorddy N., da Silva, Carlos H. T. de P., Federico, Leonardo B., Oliveira, Edivaldo H. C. de, de Souza, Michel P. C., da Silva, Patrícia N. B., Taft, Carlton A., Ferreira, Irlon M., Gomes, Madson R. F.

“…Glioblastoma is an aggressive primary tumor of the central nervous system (CNS). Is the most aggressive among infiltrative gliomas arising from the CNS. This…”
Get full text

Molecular modeling approaches of selective adenosine receptor type 2A agonists as potential anti-inflammatory drugs by Santos, Cleydson B. R., Santos, Kelton L. B., Cruz, Jorddy N., Leite, Franco H. A., Borges, Rosivaldo S., Taft, Carlton A., Campos, Joaquín M., Silva, Carlos H. T. P.

“…Adenosine A 2A receptor (A 2A R) is the predominant receptor in immune cells, where its activation triggers cAMP-mediated immunosuppressive signaling and the…”
Get full text