Renally Excretable and Size-Tunable Silver Sulfide Nanoparticles for Dual-Energy Mammography or Computed Tomography
Significant effort has been focused on developing renally clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual-energy mammography, computed tomogr...
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| Published in: | Chemistry of materials Vol. 31; no. 19; pp. 7845 - 7854 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
American Chemical Society
08-10-2019
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Significant effort has been focused on developing renally clearable nanoparticle agents since efficient renal clearance is important for eventual clinical translation. Silver sulfide nanoparticles (Ag2S-NP) have recently been identified as contrast agents for dual-energy mammography, computed tomography (CT), and fluorescence imaging and probes for drug delivery and photothermal therapy with good biocompatibility. However, most Ag2S-NP reported to date are not renally excretable and are observed in vivo to accumulate and remain in the reticuloendothelial system (RES) organs, i.e., liver and spleen, for a long time, which could negatively impact their likelihood for translation. Herein, we present renally clearable, 3.1 nm Ag2S-NP with 85% of the injected dose (ID) being excreted within 24 h of intravenous injection, which is among the best clearance of similarly sized nanoparticles reported thus far (mostly between 20 and 75% of ID). The urinary excretion and low RES accumulation of these nanoparticles in mice were indicated by in vivo CT imaging and biodistribution analysis. In summary, these ultrasmall Ag2S-NP can be effectively eliminated via urine and have high translational potential for various biomedical applications. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0897-4756 1520-5002 |
| DOI: | 10.1021/acs.chemmater.9b01750 |