Search Results - "Cruz, E. B."

Exosome isolation from distinct biofluids using precipitation and column-based approaches by Soares Martins, Tânia, Catita, José, Martins Rosa, Ilka, A B da Cruz E Silva, Odete, Henriques, Ana Gabriela

“…The potential of exosomes as biomarker resources for diagnostics, prognostics and even for therapeutics is an area of intense research. Despite the various…”
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Nuclear envelope dysfunction and its contribution to the aging process by Martins, Filipa, Sousa, Jéssica, Pereira, Cátia D., Cruz e Silva, Odete A. B., Rebelo, Sandra

“…The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface…”
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Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis by Soares Martins, Tânia, Marçalo, Rui, da Cruz e Silva, Cristóvão B., Trindade, Dário, Catita, José, Amado, Francisco, Melo, Tânia, Rosa, Ilka Martins, Vogelgsang, Jonathan, Wiltfang, Jens, da Cruz e Silva, Odete A. B., Henriques, Ana Gabriela

“…Exosomes are small extracellular vesicles (EVs) present in human biofluids that can transport specific disease-associated molecules. Consequently blood-derived…”
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Altered protein phosphorylation as a resource for potential AD biomarkers by Henriques, Ana Gabriela, Müller, Thorsten, Oliveira, Joana Machado, Cova, Marta, da Cruz e Silva, Cristóvão B., da Cruz e Silva, Odete A. B.

“…The amyloidogenic peptide, Aβ, provokes a series of events affecting distinct cellular pathways regulated by protein phosphorylation. Aβ inhibits protein…”
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Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility by Pereira, Cátia D., Serrano, Joana B., Martins, Filipa, Cruz e Silva, Odete A. B., Rebelo, Sandra

“…ABSTRACT The production of highly specialized spermatozoa from undifferentiated spermatogonia is a strictly organized and programmed process requiring…”
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Exosomal Aβ-Binding Proteins Identified by "In Silico" Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease by Soares Martins, Tânia, Marçalo, Rui, Ferreira, Maria, Vaz, Margarida, Silva, Raquel M, Martins Rosa, Ilka, Vogelgsang, Jonathan, Wiltfang, Jens, da Cruz E Silva, Odete A B, Henriques, Ana Gabriela

“…The potential of exosomes as biomarker resources for diagnostics and even for therapeutics has intensified research in the field, including in the context of…”
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Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease by Soares Martins, Tânia, Pelech, Steven, Ferreira, Maria, Pinho, Beatriz, Leandro, Kevin, de Almeida, Luís Pereira, Breitling, Benedict, Hansen, Niels, Esselmann, Hermann, Wiltfang, Jens, da Cruz E Silva, Odete A B, Henriques, Ana Gabriela

“…Phosphorylation plays a key role in Alzheimer's disease (AD) pathogenesis, impacting distinct processes such as amyloid-beta (Aβ) peptide production and tau…”
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Nuclear Envelope Alterations in Myotonic Dystrophy Type 1 Patient-Derived Fibroblasts by Viegas, Diana, Pereira, Cátia D, Martins, Filipa, Mateus, Tiago, da Cruz E Silva, Odete A B, Herdeiro, Maria Teresa, Rebelo, Sandra

“…Myotonic dystrophy type 1 (DM1) is a hereditary and multisystemic disease characterized by myotonia, progressive distal muscle weakness and atrophy. The…”
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NMR metabolomics to study the metabolic response of human osteoblasts to non‐poled and poled poly (L‐lactic) acid by Araújo, Rita, Carneiro, Tatiana J., Marinho, Paula, Costa, Marisa Maltez, Roque, Ana, Cruz e Silva, Odete A. B., Fernandes, Maria Helena, Vilarinho, Paula M., Gil, Ana M.

“…Untargeted nuclear magnetic resonance (NMR) metabolomics was employed, for the first time to our knowledge, to characterize the metabolome of human osteoblast…”
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Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease by Ferreira, Maria J. Cardoso, Soares Martins, Tânia, Alves, Steven R., Rosa, Ilka Martins, Vogelgsang, Jonathan, Hansen, Niels, Wiltfang, Jens, da Cruz e Silva, Odete A. B., Vitorino, Rui, Henriques, Ana Gabriela

“…Aging is the main risk factor for the appearance of age‐related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common form of…”
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The effects of rituximab on the lipid profile of patients with active systemic lupus erythematosus: results from a nationwide cohort in Spain (LESIMAB) by Fernández-Nebro, A, Marenco, JL, López-Longo, F, Galindo, M, Hernández-Cruz, BE, Narváez, J, Rúa-Figueroa, Í I, Raya-Alvarez, E, Zea, A, Freire, M, Sánchez-Atrio, AI, García-Vicuña, R, Pego-Reigosa, JM, Manrique-Arija, S, Nieves-Martín, L, Carreño, L

“…Introduction Patients with systemic lupus erythematosus (SLE) have increased cardiovascular risk related to lipid changes induced by inflammatory activity,…”
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Analysis of the amyloid precursor protein role in neuritogenesis reveals a biphasic SH‐SY5Y neuronal cell differentiation model by Rocha, Joana Fernandes, Cruz e Silva, Odete A. B., Vieira, Sandra Isabel

“…The existence of an intrinsic programme controlling neuritogenesis and activated during early neuronal differentiation and regeneration stages is well…”
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Fourier-Transform Infrared Spectroscopy as a Discriminatory Tool for Myotonic Dystrophy Type 1 Metabolism: A Pilot Study by Mateus, Tiago, Almeida, Idália, Costa, Adriana, Viegas, Diana, Magalhães, Sandra, Martins, Filipa, Herdeiro, Maria Teresa, da Cruz E Silva, Odete A B, Fraga, Carla, Alves, Ivânia, Nunes, Alexandra, Rebelo, Sandra

“…Myotonic dystrophy type 1 (DM1) is a hereditary disease characterized by progressive distal muscle weakness and myotonia. Patients with DM1 have abnormal lipid…”
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Multicenter longitudinal study of B-lymphocyte depletion in refractory systemic lupus erythematosus: the LESIMAB study by Fernández-Nebro, A, de la Fuente, JL Marenco, Carreño, L, Izquierdo, M Galindo, Tomero, E, Rúa-Figueroa, I, Hernández-Cruz, BE, Narváez, J, Úcar, E, Olivé, A, Zea, A, Fernández-Castro, M, Raya-Álvarez, E, Pego-Reigosa, JM, Freire, M, Martínez-Taboada, VM, Pérez-Venegas, J, Sánchez-Atrio, AI, Villa-Blanco, I, Manrique-Arija, S, López-Longo, FJ, Carreira, PE, Martínez-Pérez, R, García-Vicuña, R

“…Objective: This study aimed to investigate the effectiveness and safety of single and repeated courses of rituximab in patients with refractory lupus. Methods:…”
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Toward Neuroproteomics in Biological Psychiatry: A Systems Approach Unravels Okadaic Acid-Induced Alterations in the Neuronal Phosphoproteome by Oliveira, Joana Machado, da Cruz E Silva, Cristóvão B, Müller, Thorsten, Martins, Tânia Soares, Cova, Marta, da Cruz E Silva, Odete A B, Henriques, Ana Gabriela

“…Neuroproteomics is an evolving field of postgenomic medicine, highlighting the convergence of psychiatry/neurology and proteomics, yet compared with…”
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An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model by Korrodi-Gregório, Luís, Margarida Lopes, Ana, Esteves, Sara L C, Afonso, Sandra, Lemos de Matos, Ana, Lissovsky, Andrey A, da Cruz e Silva, Odete A B, da Cruz e Silva, Edgar F, Esteves, Pedro José, Fardilha, Margarida

“…T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the…”
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Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease by Baptista, Filipa I, Henriques, Ana G, Silva, Artur M. S, Wiltfang, Jens, da Cruz e Silva, Odete A. B

“…Alzheimer’s disease is characterized by pathological aggregation of protein tau and amyloid-β peptides, both of which are considered to be toxic to neurons…”
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APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis by da Rocha, Joana F., Bastos, Luísa, Domingues, Sara C., Bento, Ana R., Konietzko, Uwe, da Cruz e Silva, Odete A. B., Vieira, Sandra I.

“…The amyloid precursor protein (APP) is a transmembrane glycoprotein central to Alzheimer’s disease (AD) with functions in brain development and plasticity,…”
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Identification and characterization of the BRI2 interactome in the brain by Martins, Filipa, Marafona, Ana M., Pereira, Cátia D., Müller, Thorsten, Loosse, Christina, Kolbe, Katharina, da Cruz e Silva, Odete A. B., Rebelo, Sandra

“…BRI family proteins are ubiquitous type II transmembrane proteins but BRI2 is highly expressed in some neuronal tissues. Possible BRI2 functions include…”
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Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration by Trigo, Diogo, Vitória, José, da Cruz e Silva, Odete

“…In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset…”
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