Search Results - "Crute, J J"

Crystallographic Analysis of CD40 Recognition and Signaling by Human TRAF2 by McWhirter, Sarah M., Pullen, Steven S., Holton, James M., Crute, James J., Kehry, Marilyn R., Alber, Tom

“…Tumor necrosis factor receptor superfamily members convey signals that promote diverse cellular responses. Receptor trimerization by extracellular ligands…”
Get full text

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease by Crute, James J, Grygon, Christine A, Hargrave, Karl D, Simoneau, Bruno, Faucher, Anne-Marie, Bolger, Gordon, Kibler, Philip, Liuzzi, Michel, Cordingley, Michael G

“…Herpes simplex virus infections are the cause of significant morbidity, and currently used therapeutics are largely based on modified nucleoside analogs that…”
Get full text

CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions:  Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization by Pullen, Steven S, Miller, Heather G, Everdeen, Daniel S, Dang, Thu T. A, Crute, James J, Kehry, Marilyn R

“…CD40 is a TNF receptor superfamily member that provides activation signals in antigen-presenting cells such as B cells, macrophages, and dendritic cells…”
Get full text

High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization by Pullen, Steven S, Labadia, Mark E, Ingraham, Richard H, McWhirter, Sarah M, Everdeen, Daniel S, Alber, Tom, Crute, James J, Kehry, Marilyn R

“…Signaling by some TNF receptor family members, including CD40, is mediated by TNF receptor-associated factors (TRAFs) that interact with receptor cytoplasmic…”
Get full text

CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs by Pullen, S S, Dang, T T, Crute, J J, Kehry, M R

“…Tumor necrosis factor receptor-associated factors (TRAFs) associate with the CD40 cytoplasmic domain and initiate signaling after CD40 receptor multimerization…”
Get full text

Molecular Characterization of CD40 Signaling Intermediates by Werneburg, B G, Zoog, S J, Dang, T T, Kehry, M R, Crute, J J

“…Signal transduction through the CD40 receptor is initiated by binding of its trimeric ligand and propagated by interactions of tumor necrosis factor…”
Get full text

Herpes simplex-1 DNA polymerase. Identification of an intrinsic 5'----3' exonuclease with ribonuclease H activity by CRUTE, J. J, LEHMAN, I. R

“…The herpes simplex virus-1 DNA polymerase is a heterodimer of Mr 190,000 which consists of the products of the UL30 (Pol) and UL42 genes. The 136-kilodalton…”
Get full text

Herpes Simplex Virus 1 Helicase-Primase: A Complex of Three Herpes-Encoded Gene Products by Crute, James J., Tsurumi, Tatsuya, Zhu, Liang, Weller, Sandra K., Olivo, Paul D., Challberg, Mark D., Mocarski, Edward S., Lehman, I. R.

“…In an earlier report, we described a DNA helicase that is specifically induced upon infection of Vero cells with herpes simplex virus 1. We have purified this…”
Get full text

The herpes simplex virus 1 origin binding protein: a DNA helicase by BRUCKNER, R. C, CRUTE, J. J, DODSON, M. S, LEHMAN, I. R

“…A recombinant herpes simplex 1 origin binding protein, the product of the herpes UL9 gene, has been overexpressed in mammalian cells and purified to near…”
Get full text

Assembly of Major Histocompatability Complex (MHC) Class II Transcription Factors:  Association and Promoter Recognition of RFX Proteins by Burd, Amy L, Ingraham, Richard H, Goldrick, Susan E, Kroe, Rachel R, Crute, James J, Grygon, Christine A

“…Major histocompatibility complex (MHC) class II genes are regulated at the transcriptional level by coordinate action of a limited number of transcription…”
Get full text

Herpes simplex virus-1 helicase-primase. Physical and catalytic properties by CRUTE, J. J, LEHMAN, I. R

“…Herpes simplex virus type 1 (HSV-1) encodes a helicase-primase that consists of the products of the UL5, UL8, and UL52 genes (Crute, J. J., Tsurumi, T., Zhu,…”
Get full text

Identification of the Primase Active Site of the Herpes Simplex Virus Type 1 Helicase-Primase by Dracheva, Stella, Koonin, Eugene V., Crute, James J.

“…Herpes simplex virus type 1 (HSV-1) encodes a heterotrimeric helicase-primase composed of the products of the three DNA replication-specific genes UL5, UL8,…”
Get full text

Overexpression and Assembly of the Herpes Simplex Virus Type 1 Helicase-Primase in Insect Cells by Dodson, M S, Crute, J J, Bruckner, R C, Lehman, I R

“…Herpes simplex virus type 1 (HSV-1) encodes a helicase-primase that consists of three polypeptides encoded by the UL5, UL8, and UL52 genes (Crute, J.J.,…”
Get full text

A DNA helicase induced by herpes simplex virus type 1 by Crute, J J, Mocarski, E S, Lehman, I R

“…We have identified and partially purified a DNA-dependent ATPase that is present specifically in herpes simplex virus type 1-infected Vero cells. The enzyme…”
Get full text

Gain-of-function somatic cell lines for drug discovery applications generated by homologous recombination by Zeh, Karin, Sanders, Pamela, Londo, Phillip, Crute, James J, Pollok, Brian A, Whitney, Michael A

“…Gene targeting allows for precise genomic engineering and has been used extensively to generate both loss-of-function and gain-of-function models in mice…”
Get more information

The beta subunit of the Escherichia coli DNA polymerase III holoenzyme interacts functionally with the catalytic core in the absence of other subunits by LaDuca, R J, Crute, J J, McHenry, C S, Bambara, R A

“…We have previously demonstrated that the addition of a stoichiometric excess of the beta subunit of Escherichia coli DNA polymerase III holoenzyme to DNA…”
Get full text

Herpes simplex-1 helicase-primase. Identification of two nucleoside triphosphatase sites that promote DNA helicase action by Crute, J.J., Bruckner, R.C., Dodson, M.S., Lehman, I.R.

“…Herpes simplex virus type 1 (HSV-1) encodes a heterotrimeric helicase-primase comprised of the products of the UL5, UL8, and UL52 genes (Crute, J. J., and…”
Get full text

Characterization of the Human Cytomegalovirus UL105 Gene and Identification of the Putative Helicase Protein by SMITH, JEAN A., JAIRATH, SANJU, CRUTE, JAMES J., PARI, GREGORY S.

“…We have characterized the transcription unit for the human cytomegalovirus UL105 gene and identified its putative protein product. The UL105 gene product is…”
Get full text

Inhibition of Herpes Simplex Virus Type 1 Helicase-Primase by (Dichloroanilino)purines and -pyrimidines by Crute, James J, Lehman, I. Robert, Gambino, Joseph, Yang, Te-Fang, Medveczky, Peter, Medveczky, Mary, Khan, Naseema N, Mulder, Carel, Monroe, James, Wright, George E

“…Herpes simplex virus type 1 (HSV1) encodes a heterotrimeric helicase-primase comprised of the products of three of the seven DNA replication-specific genes…”
Get full text

Structural and biochemical analysis of signal transduction by the TRAF family of adapter proteins by McWhirter, S M, Pullen, S S, Werneburg, B G, Labadia, M E, Ingraham, R H, Crute, J J, Kehry, M R, Alber, T

Get full text