Search Results - "Crumley, Gregg"

DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties by Valenzano, Kenneth J, Miller, Wendy, Chen, Zhengming, Shan, Shen, Crumley, Gregg, Victory, Sam F, Davies, Ellen, Huang, Jin-Cheng, Allie, Nezima, Nolan, Scott J, Rotshteyn, Yakov, Kyle, Donald J, Broglé, Kevin

“…Mu opioid receptors are present throughout the central and peripheral nervous systems. Peripheral inflammation causes an increase in mu receptor levels on…”
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A miniaturized column chromatography method for measuring receptor-mediated inositol phosphate accumulation by Benjamin, Elfrida R, Haftl, Sarah L, Xanthos, Dimitris N, Crumley, Gregg, Hachicha, Mohamed, Valenzano, Kenneth J

“…Inositol phosphates (IPs), such as 1,4,5-inositol-trisphosphate (IP(3)), comprise a ubiquitous intracellular signaling cascade initiated in response to G…”
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Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function by Carlin, Kevin P., Wu, Gang, Patel, Aniket, Crumley, Gregg, Ilyin, Victor I.

“…Transient receptor potential vanilloid type 1 (TRPV1) channels are capable of detecting and integrating noxious stimuli and play an important role in…”
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State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents by Benjamin, Elfrida R, Pruthi, Farhana, Olanrewaju, Shakira, Ilyin, Victor I, Crumley, Gregg, Kutlina, Elena, Valenzano, Kenneth J, Woodward, Richard M

“…Voltage-gated sodium channels (NaChs) are relevant targets for pain, epilepsy, and a variety of neurological and cardiac disorders. Traditionally, it has been…”
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Cloning and expression of two distinct high‐affinity receptors cross‐reacting with acidic and basic fibroblast growth factors by Dionne, C. A., Crumley, G., Bellot, F., Kaplow, J. M., Searfoss, G., Ruta, M., Burgess, W. H., Jaye, M., Schlessinger, J.

“…The fibroblast growth factor (FGF) family consists of at least seven closely related polypeptide mitogens which exert their activities by binding and…”
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Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties by Hjälm, G, Murray, E, Crumley, G, Harazim, W, Lundgren, S, Onyango, I, Ek, B, Larsson, M, Juhlin, C, Hellman, P, Davis, H, Akerström, G, Rask, L, Morse, B

“…We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous…”
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Cloning and Sequencing of Human gp330, a Ca2+‐Binding Receptor with Potential Intracellular Signaling Properties by Hjälm, Göran, Murray, Edward, Crumley, Gregg, Harazim, William, Lundgren, Stefan, Onyango, Isaac, Ek, Bo, Larsson, Mårten, Juhlin, Claes, Hellman, Per, Davis, Hugh, Åkerström, Göran, Rask, Lars, Morse, Buzzy

“…We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous…”
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High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF by Crumley, G, Bellot, F, Kaplow, J M, Schlessinger, J, Jaye, M, Dionne, C A

“…We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors…”
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Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek by Kaplow, J M, Bellot, F, Crumley, G, Dionne, C A, Jaye, M

“…Heparin potentiates the mitogenic activity of acidic fibroblast growth factor (aFGF) by 20-100 fold but mechanisms detailing this potentiation have not yet…”
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Cloning and Sequencing of Human gp330, a Ca 2+ ‐Binding Receptor with Potential Intracellular Signaling Properties by Hjälm, Göran, Murray, Edward, Crumley, Gregg, Harazim, William, Lundgren, Stefan, Onyango, Isaac, Ek, Bo, Larsson, Mårten, Juhlin, Claes, Hellman, Per, Davis, Hugh, Åkerström, Göran, Rask, Lars, Morse, Buzzy

“…We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous…”
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The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon by Crumley, G, Dionne, C A, Jaye, M

“…We have isolated two cDNA clones encoding human acidic fibroblast growth factor (aFGF) which represent the utilization of alternative upstream exons in aFGF…”
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Multiple polyadenylation sites downstream from the human aFGF gene encoding acidic fibroblast growth factor by Crumley, G R, Howk, R, Ravera, M W, Jaye, M

“…We previously reported the isolation of two partial cDNA clones encoding human acidic fibroblast growth factor (aFGF). The nucleotide (nt) sequence throughout…”
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Modulation of expression of the human gamma interferon gene in E. coli by site-directed mutagenesis by Lee, S G, Ricca, G A, Crumley, G, Lloyd, R S, Drohan, W

“…Plasmids expressing 2 forms of human immune interferon (IFN-gamma) in E. coli have been constructed: 1) pIFNTacI which expresses IFN-gamma with an N-terminal…”
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