Search Results - "Cruickshank, Sheena M"

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 by Denes, Adam, Coutts, Graham, Lénárt, Nikolett, Cruickshank, Sheena M., Pelegrin, Pablo, Skinner, Joanne, Rothwell, Nancy, Allan, Stuart M., Brough, David

“…Significance Cerebral ischemia (CI; stroke, brain injury, vascular dementia, neonatal hypoxia, and many other conditions) affects people at all stages of life…”
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Local Arginase 1 Activity Is Required for Cutaneous Wound Healing by Campbell, Laura, Saville, Charis R., Murray, Peter J., Cruickshank, Sheena M., Hardman, Matthew J.

“…Chronic nonhealing wounds in the elderly population are associated with a prolonged and excessive inflammatory response, which is widely hypothesized to impede…”
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Cage and maternal effects on the bacterial communities of the murine gut by Singh, Gurdeep, Brass, Andrew, Cruickshank, Sheena M., Knight, Christopher G.

“…Findings from gut microbiome studies are strongly influenced by both experimental and analytical factors that can unintentionally bias their interpretation…”
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A quantitative brain map of experimental cerebral malaria pathology by Strangward, Patrick, Haley, Michael J, Shaw, Tovah N, Schwartz, Jean-Marc, Greig, Rachel, Mironov, Aleksandr, de Souza, J Brian, Cruickshank, Sheena M, Craig, Alister G, Milner, Jr, Danny A, Allan, Stuart M, Couper, Kevin N

“…The murine model of experimental cerebral malaria (ECM) has been utilised extensively in recent years to study the pathogenesis of human cerebral malaria…”
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Microbial Host Interactions and Impaired Wound Healing in Mice and Humans: Defining a Role for BD14 and NOD2 by Williams, Helen, Campbell, Laura, Crompton, Rachel A., Singh, Gurdeep, McHugh, Brian J., Davidson, Donald J., McBain, Andrew J., Cruickshank, Sheena M., Hardman, Matthew J.

“…Chronic wounds cause significant patient morbidity and mortality. A key factor in their etiology is microbial infection, yet skin host-microbiota interactions…”
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Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes by Cox, Joshua R, Cruickshank, Sheena M, Saunders, Amy E

“…Mucosal surfaces, as a first barrier with the environment are especially susceptible to damage from both pathogens and physical trauma. Thus, these sites…”
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Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation by Glymenaki, Maria, Singh, Gurdeep, Brass, Andrew, Warhurst, Geoffrey, McBain, Andrew J, Else, Kathryn J, Cruickshank, Sheena M

“…Inflammatory bowel disease (IBD) is associated with an inappropriate immune response to the gut microbiota. Notably, patients with IBD reportedly have…”
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Characterisation of cuticular inflation development and ultrastructure in Trichuris muris using correlative X-ray computed tomography and electron microscopy by O’Sullivan, James D. B., Cruickshank, Sheena M., Starborg, Tobias, Withers, Philip J., Else, Kathryn J.

“…The parasitic nematode Trichuris trichiura is a significant burden on public health in developing countries, and currently available drugs exhibit a poor cure…”
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Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge by Walker, Catherine R, Hautefort, Isabelle, Dalton, Jane E, Overweg, Karin, Egan, Charlotte E, Bongaerts, Roy J, Newton, Darren J, Cruickshank, Sheena M, Andrew, Elizabeth M, Carding, Simon R

“…Antimicrobial proteins influence intestinal microbial ecology and limit proliferation of pathogens, yet the regulation of their expression has only been…”
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Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing by Szondi, Denis C., Wong, Jason K., Vardy, Leah A., Cruickshank, Sheena M.

“…Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the…”
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P2X7 receptor‐dependent tuning of gut epithelial responses to infection by Huang, Szu‐Wei, Walker, Catherine, Pennock, Joanne, Else, Kathryn, Muller, Werner, Daniels, Michael JD, Pellegrini, Carolina, Brough, David, Lopez‐Castejon, Gloria, Cruickshank, Sheena M

“…Infection and injury of the gut are associated with cell damage and release of molecules such as extracellular adenosine 5′‐triphosphate (ATP), which is…”
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A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles by Huggins, Lucas G, Michaels, Christopher J, Cruickshank, Sheena M, Preziosi, Richard F, Else, Kathryn J

“…Anthropogenic disturbance via resource acquisition, habitat fragmentation and climate change, amongst other factors, has led to catastrophic global…”
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Correction: A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles by Huggins, Lucas G, Michaels, Christopher J, Cruickshank, Sheena M, Preziosi, Richard F, Else, Kathryn J

“…[This corrects the article DOI: 10.1371/journal.pone.0185151.]…”
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A culture shift to support public involvement and engagement in research by Eberl, Matthias, Cruickshank, Sheena M

“…The need to empower people to understand their health and well-being has never been greater. However, current research culture does not necessarily prioritize…”
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Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound-healing response by Campbell, Laura, Williams, Helen, Crompton, Rachel A, Cruickshank, Sheena M, Hardman, Matthew J

“…Infection is a significant causative factor in human chronic wounds that fail to heal. Complex innate host response mechanisms have evolved whereby potentially…”
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Gut eosinophils and their impact on the mucus‐resident microbiota by Singh, Gurdeep, Brass, Andrew, Knight, Christopher G., Cruickshank, Sheena M.

“…Summary The gut has the largest commensal bacterial population in the body and its composition can be impacted by host factors such as production of…”
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Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival by Cruickshank, Sheena-M, Wakenshaw, Louise, Cardone, John, Howdle, Peter-D, Murray, Peter-J, Carding, Simon-R

“…AIM： To investigate the function of NOD2 in colonic epithelial cells （CEC）. METHODS： A combination of in vivo and in vitro analyses of epithelial cell turnover…”
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Lactobacillus rhamnosus GG inhibits the toxic effects of Staphylococcus aureus on epidermal keratinocytes by Mohammedsaeed, Walaa, McBain, Andrew J, Cruickshank, Sheena M, O'Neill, Catherine A

“…Few studies have evaluated the potential benefits of the topical application of probiotic bacteria or material derived from them. We have investigated whether…”
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Eosinophils are key regulators of perivascular adipose tissue and vascular functionality by Withers, Sarah B., Forman, Ruth, Meza-Perez, Selene, Sorobetea, Daniel, Sitnik, Kasia, Hopwood, Thomas, Lawrence, Catherine B., Agace, William W., Else, Kathryn J., Heagerty, Anthony M., Svensson-Frej, Marcus, Cruickshank, Sheena M.

“…Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension…”
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Characterization of colonic dendritic cells in normal and colitic mice by Cruickshank, Sheena M, English, Nicholas R, Felsburg, Peter J, Carding, Simon R

“…Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel…”
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