Search Results - "Crucian, Brian E"

Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome by Voorhies, Alexander A., Mark Ott, C., Mehta, Satish, Pierson, Duane L., Crucian, Brian E., Feiveson, Alan, Oubre, Cherie M., Torralba, Manolito, Moncera, Kelvin, Zhang, Yun, Zurek, Eduardo, Lorenzi, Hernan A.

“…Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the…”
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Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions by Crucian, Brian E, Choukèr, Alexander, Simpson, Richard J, Mehta, Satish, Marshall, Gailen, Smith, Scott M, Zwart, Sara R, Heer, Martina, Ponomarev, Sergey, Whitmire, Alexandra, Frippiat, Jean P, Douglas, Grace L, Lorenzi, Hernan, Buchheim, Judith-Irina, Makedonas, George, Ginsburg, Geoffrey S, Ott, C Mark, Pierson, Duane L, Krieger, Stephanie S, Baecker, Natalie, Sams, Clarence

“…Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a…”
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Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth by Rooney, Bridgette V, Crucian, Brian E, Pierson, Duane L, Laudenslager, Mark L, Mehta, Satish K

“…Latent herpes virus reactivation has been demonstrated in astronauts during shuttle (10-16 days) and International Space Station (≥180 days) flights. Following…”
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NK cell function is impaired during long-duration spaceflight by Bigley, Austin B, Agha, Nadia H, Baker, Forrest L, Spielmann, Guillaume, Kunz, Hawley E, Mylabathula, Preteesh L, Rooney, Bridgette V, Laughlin, Mitzi S, Mehta, Satish K, Pierson, Duane L, Crucian, Brian E, Simpson, Richard J

“…Maintaining astronaut health during space travel is paramount for further human exploration of the solar system beyond Earth's orbit. Of concern are potential…”
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Arterial structure and function during and after long-duration spaceflight by Lee, Stuart M C, Ribeiro, L Christine, Martin, David S, Zwart, Sara R, Feiveson, Alan H, Laurie, Steven S, Macias, Brandon R, Crucian, Brian E, Krieger, Stephanie, Weber, Daniela, Grune, Tilman, Platts, Steven H, Smith, Scott M, Stenger, Michael B

“…Spaceflight missions expose astronauts to increased risk of oxidative stress and inflammatory damage that might accelerate the development of asymptomatic…”
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Temporal Telomere and DNA Damage Responses in the Space Radiation Environment by Luxton, Jared J., McKenna, Miles J., Taylor, Lynn E., George, Kerry A., Zwart, Sara R., Crucian, Brian E., Drel, Viktor R., Garrett-Bakelman, Francine E., Mackay, Matthew J., Butler, Daniel, Foox, Jonathan, Grigorev, Kirill, Bezdan, Daniela, Meydan, Cem, Smith, Scott M., Sharma, Kumar, Mason, Christopher E., Bailey, Susan M.

“…Telomeres, repetitive terminal features of chromosomes essential for maintaining genome integrity, shorten with cell division, lifestyle factors and stresses,…”
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Effect of Simulated Cosmic Radiation on Cytomegalovirus Reactivation and Lytic Replication by Mehta, Satish K, Diak, Douglass M, Bustos-Lopez, Sara, Nelman-Gonzalez, Mayra, Chen, Xi, Plante, Ianik, Stray, Stephen J, Tandon, Ritesh, Crucian, Brian E

“…Human exploration of the solar system will expose crew members to galactic cosmic radiation (GCR), with a potential for adverse health effects. GCR particles…”
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Increased core body temperature in astronauts during long-duration space missions by Stahn, Alexander C., Werner, Andreas, Opatz, Oliver, Maggioni, Martina A., Steinach, Mathias, von Ahlefeld, Victoria Weller, Moore, Alan, Crucian, Brian E., Smith, Scott M., Zwart, Sara R., Schlabs, Thomas, Mendt, Stefan, Trippel, Tobias, Koralewski, Eberhard, Koch, Jochim, Choukèr, Alexander, Reitz, Günther, Shang, Peng, Röcker, Lothar, Kirsch, Karl A., Gunga, Hanns-Christian

“…Humans’ core body temperature (CBT) is strictly controlled within a narrow range. Various studies dealt with the impact of physical activity, clothing, and…”
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Neutrophil-to-Lymphocyte Ratio: A Biomarker to Monitor the Immune Status of Astronauts by Paul, Amber M, Mhatre, Siddhita D, Cekanaviciute, Egle, Schreurs, Ann-Sofie, Tahimic, Candice G T, Globus, Ruth K, Anand, Sulekha, Crucian, Brian E, Bhattacharya, Sharmila

“…A comprehensive understanding of spaceflight factors involved in immune dysfunction and the evaluation of biomarkers to assess in-flight astronaut health are…”
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Single Drop Cytometry Onboard the International Space Station by Rea, Daniel J., Miller, Rachael S., Crucian, Brian E., Valentine, Russell W., Cristoforetti, Samantha, Bearg, Samuel B., Sipic, Zlatko, Cheng, Jamie, Yu, Rebecca, Calaway, Kimesha M., Eames, Dexter, Nelson, Emily S., Lewandowski, Beth E., Perusek, Gail P., Chan, Eugene Y.

“…Real-time lab analysis is needed to support clinical decision making and research on human missions to the Moon and Mars. Powerful laboratory instruments, such…”
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Latent virus reactivation in astronauts on the international space station by Mehta, Satish K., Laudenslager, Mark L., Stowe, Raymond P., Crucian, Brian E., Feiveson, Alan H., Sams, Clarence F., Pierson, Duane L.

“…Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight…”
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Human Health during Space Travel: State-of-the-Art Review by Krittanawong, Chayakrit, Singh, Nitin Kumar, Scheuring, Richard A, Urquieta, Emmanuel, Bershad, Eric M, Macaulay, Timothy R, Kaplin, Scott, Dunn, Carly, Kry, Stephen F, Russomano, Thais, Shepanek, Marc, Stowe, Raymond P, Kirkpatrick, Andrew W, Broderick, Timothy J, Sibonga, Jean D, Lee, Andrew G, Crucian, Brian E

“…The field of human space travel is in the midst of a dramatic revolution. Upcoming missions are looking to push the boundaries of space travel, with plans to…”
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Time-resolved molecular measurements reveal changes in astronauts during spaceflight by Zheng, Minzhang, Charvat, Jacqueline, Zwart, Sara R, Mehta, Satish K, Crucian, Brian E, Smith, Scott M, He, Jin, Piermarocchi, Carlo, Mias, George I

“…From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity,…”
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Silent Reactivation of Varicella Zoster Virus in Pregnancy: Implications for Maintenance of Immunity to Varicella by Mourad, Mirella, Gershon, Michael, Mehta, Satish K, Crucian, Brian E, Hubbard, Nicole, Zhang, Jing, Gershon, Anne

“…We encountered two cases of varicella occurring in newborn infants. Because the time between birth and the onset of the illness was much shorter than the…”
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DNA Damage and Radiosensitivity in Blood Cells from Subjects Undergoing 45 Days of Isolation and Confinement: An Explorative Study by Feiveson, Alan H., Krieger, Stephanie S., von Scheven, Gudrun, Crucian, Brian E., Bürkle, Alexander, Stahn, Alexander C., Wu, Honglu, Moreno-Villanueva, María

“…The effect of confined and isolated experience on astronauts’ health is an important factor to consider for future space exploration missions. The more…”
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Towards human exploration of space: The THESEUS review series on immunology research priorities by Frippiat, Jean-Pol, Crucian, Brian E, de Quervain, Dominique J-F, Grimm, Daniela, Montano, Nicola, Praun, Siegfried, Roozendaal, Benno, Schelling, Gustav, Thiel, Manfred, Ullrich, Oliver, Choukèr, Alexander

“…Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged…”
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Dermatitis during Spaceflight Associated with HSV-1 Reactivation by Mehta, Satish K., Szpara, Moriah L., Rooney, Bridgette, Diak, Douglass M., Shipley, Mackenzie M., Renner, Daniel W., Krieger, Stephanie S., Zwart, Sara R., Smith, Scott M., Crucian, Brian E.

“…Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia and often reactivate…”
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Localization of VZV in saliva of zoster patients by Mehta, Satish K., Nelman‐Gonzalez, Mayra, Tyring, Stephen K., Tong, Yun, Beitman, Andrew, Crucian, Brian E., Renner, Ashlie N., Pierson, Duane L.

“…Varicella zoster virus (VZV) in saliva from six herpes zoster patients and one chickenpox patient was found to be exclusively associated with epithelial cells…”
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Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice by Paul, Amber M., Cheng-Campbell, Margareth, Blaber, Elizabeth A., Anand, Sulekha, Bhattacharya, Sharmila, Zwart, Sara R., Crucian, Brian E., Smith, Scott M., Meller, Robert, Grabham, Peter, Beheshti, Afshin

“…Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune…”
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Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station by Mehta, Satish K., Suresh, Rahul, Brandt, Keith, Diak, Douglass M., Smith, Scott M., Zwart, Sara R., Douglas, Grace, Nelman-Gonzalez, Mayra, Clemett, Simon, Brunstetter, Tyson, Crucian, Brian E.

“…A case report detailing, for the first time, a case of laboratory-confirmed zoster in an astronaut on board the International Space Station is presented. The…”
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