Search Results - "Crozet, Maxime D."

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities by Mathias, Fanny, Kabri, Youssef, Okdah, Liliane, Di Giorgio, Carole, Rolain, Jean-Marc, Spitz, Cédric, Crozet, Maxime D, Vanelle, Patrice

“…A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1 -imidazole under microwave heating was…”
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Synthesis and promising in vitro antiproliferative activity of sulfones of a 5-nitrothiazole series by Cohen, Anita, Crozet, Maxime D, Rathelot, Pascal, Azas, Nadine, Vanelle, Patrice

“… The synthesis in water of new sulfone derivatives under microwave irradiation is described. This eco-friendly process leads to the expected products in good…”
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High functionalization of 5-nitro-1H-imidazole derivatives: the TDAE approach by Juspin, Thierry, Zink, Laura, Crozet, Maxime D, Terme, Thierry, Vanelle, Patrice

“…We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl…”
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Rapid Synthesis of New Azaheterocyclic Hydroxymalonate Derivatives Using TDAE Approach by Vanelle, Patrice, Montana, Marc, D. Crozet, Maxime, Castera-Ducros, Caroline, Terme, Thierry

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Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents by Mathias, Fanny, Cohen, Anita, Kabri, Youssef, Negrão, Núria Waddington, Crozet, Maxime D., Docampo, Roberto, Azas, Nadine, Vanelle, Patrice

“…In continuation of our pharmacomodulation work on the nitroimidazooxazole series, we report the synthesis of new 5-substituted 6-nitroimidazooxazole…”
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Rapid synthesis of new 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1- b ]oxazole as potential antibacterial drugs through one-pot cyclization and Suzuki–Miyaura coupling by Mathias, Fanny, Crozet, Maxime D., Kabri, Youssef, Vanelle, Patrice

“…Original 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazoles were prepared by reacting 1-(2,5-dibromo-4-nitro-1H-imidazol-1-yl)propan-2-ol and…”
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Efficient Access to 2,6,8-Trisubstituted 4-Aminoquinazolines through Microwave-Assisted One-Pot Chemoselective Tris-Suzuki-Miyaura or SNAr/Bis-Suzuki-Miyaura Reactions in Water by Kabri, Youssef, Crozet, Maxime D., Terme, Thierry, Vanelle, Patrice

“…An efficient, sequential, one‐pot strategy for synthesizing polyfunctionalized quinazoline derivatives is presented. After selective amination of…”
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Synthesis of new substituted imidazo[1,2-a]pyridinylpropenenitriles through sequential one-pot Suzuki-Miyaura/Knoevenagel reactions in aqueous medium by Bakhta, Saléha, Kabri, Youssef, Crozet, Maxime D., Nedjar-Kolli, Bellara, Vanelle, Patrice

“…A series of imidazo[1,2-a]pyridinylpropenenitriles were synthesized via consecutive one-pot Suzuki-Miyaura and Knoevenagel reactions in water/ethanol mixture…”
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An Efficient Synthetic Route to New Imidazo[1,2-a]pyridines by Cross-Coupling Reactions in Aqueous Medium by Vanelle, Patrice, Castera, Caroline, D. Crozet, Maxime

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8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases by Fersing, Cyril, Boudot, Clotilde, Pedron, Julien, Hutter, Sébastien, Primas, Nicolas, Castera-Ducros, Caroline, Bourgeade-Delmas, Sandra, Sournia-Saquet, Alix, Moreau, Alain, Cohen, Anita, Stigliani, Jean-Luc, Pratviel, Geneviève, Crozet, Maxime D., Wyllie, Susan, Fairlamb, Alan, Valentin, Alexis, Rathelot, Pascal, Azas, Nadine, Courtioux, Bertrand, Verhaeghe, Pierre, Vanelle, Patrice

“…Based on a previously identified antileishmanial 6,8-dibromo-3-nitroimidazo[1,2-a]pyridine derivative, a Suzuki-Miyaura coupling reaction at position 8 of the…”
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Microwave-assisted manganese(III) acetate based oxidative cyclizations of alkenes with β-ketosulfones by Curti, Christophe, Crozet, Maxime D., Vanelle, Patrice

“…The microwave-assisted synthesis of 5-(4-nitrophenyl)-2-phenyl-4-(phenylsulfonyl)-2,3-dihydrofuran ( 5a) was performed via manganese(III) acetate based…”
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First single electron transfer reaction on propargylic chloride in 5-nitroimidazole series by Neildé, Kévin, Crozet, Maxime D., Terme, Thierry, Vanelle, Patrice

“…We report here the first example of an SRN1 reaction on propargylic chloride in heterocyclic series. The reaction of…”
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Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives by Cohen, Anita, Verhaeghe, Pierre, Crozet, Maxime D., Hutter, Sébastien, Rathelot, Pascal, Vanelle, Patrice, Azas, Nadine

“…A series of naphtho[2,1-d]thiazoles was prepared in good yields under microwave irradiation with an original protocol combining tandem direct arylation and…”
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Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium by Cohen, Anita, Suzanne, Peggy, Lancelot, Jean-Charles, Verhaeghe, Pierre, Lesnard, Aurélien, Basmaciyan, Louise, Hutter, Sébastien, Laget, Michèle, Dumètre, Aurélien, Paloque, Lucie, Deharo, Eric, Crozet, Maxime D., Rathelot, Pascal, Dallemagne, Patrick, Lorthiois, Audrey, Sibley, Carol Hopkins, Vanelle, Patrice, Valentin, Alexis, Mazier, Dominique, Rault, Sylvain, Azas, Nadine

“…A preliminary in vitro screening of compounds belonging to various chemical families from our library revealed the thieno[3,2-d]pyrimidin-4(3H)-one scaffold…”
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Synthesis of new potentially bioactive bicyclic 2-pyridones by Crozet, Maxime D, George, Pascal, Crozet, Michel P, Vanelle, Patrice

“…Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like…”
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One-Pot Chemoselective Bis(Suzuki-Miyaura Cross-Coupling): Efficient Access to 3,9-Bis[(hetero)aryl]-4H-pyrido[1,2-a]pyrimidin-4-one Derivatives Under Microwave Irradiation by Kabri, Youssef, Crozet, Maxime D., Primas, Nicolas, Vanelle, Patrice

“…A one‐pot chemoselective bis(Suzuki–Miyaura cross‐coupling) reaction under microwave irradiation is reported for the 4H‐pyrido[1,2‐a]pyrimidin‐4‐one series…”
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Original synthesis of 2-substituted-4,11-dimethoxy-1-(phenylsulfonyl)-2,3-dihydro-1H-naphtho[2,3-f]indole-5,10-diones using TDAE and Cu-catalyzed reaction strategy by KHOUMERI, Omar, GIUGLIO-TONOLO, Gamal, CROZET, Maxime D, TERME, Thierry, VANELLE, Patrice

“…We report herein an original and rapid synthesis of 2-substituted-4,11-dimethoxy-1-(phenylsulfonyl)-2,3-dihydro-1H-naphtho[2 ,3-f]indole-5,10-diones by TDAE…”
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Targeting the human parasite Leishmania donovani: Discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series by Castera-Ducros, Caroline, Paloque, Lucie, Verhaeghe, Pierre, Casanova, Magali, Cantelli, Christophe, Hutter, Sébastien, Tanguy, Floriane, Laget, Michèle, Remusat, Vincent, Cohen, Anita, Crozet, Maxime D., Rathelot, Pascal, Azas, Nadine, Vanelle, Patrice

“…We report herein the discovery of antileishmanial molecules based on the imidazo[1,2-a]pyridine ring. In vitro screenings of imidazopyridines belonging to our…”
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Unexpected palladium catalyzed O-arylation occurring in 4-(4-fluoro-3-nitrophenyl)-1,2-dimethyl-5-nitro-1H-imidazole series by Zink, Laura, Neildé, Kevin, Crozet, Maxime D., Vanelle, Patrice

“…We describe herein a new unexpected palladium-catalyzed O-arylation reaction in fluorinated nitro(o-nitrophenyl)imidazole series involving arylboronic acids…”
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2,4‐Disubstituted 5‐Nitroimidazoles Potent against Clostridium difficile by Spitz, Cédric, Mathias, Fanny, Péchiné, Séverine, Doan, Tri Hanh Dung, Innocent, Jean, Pellissier, Sylvain, Di Giorgio, Carole, Crozet, Maxime D., Janoir, Claire, Vanelle, Patrice

“…Metronidazole is one of the first‐line treatments for non‐severe Clostridium difficile infections (CDI). However, resistance limits its use in cases of severe…”
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