Search Results - "Crowther, R. Anthony"

Propagation of Tau Aggregates and Neurodegeneration by Goedert, Michel, Eisenberg, David S, Crowther, R. Anthony

“…A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured amyloid fibril underlies human Tauopathies. This ordered…”
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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases by Zhang, Wenjuan, Falcon, Benjamin, Murzin, Alexey G, Fan, Juan, Crowther, R Anthony, Goedert, Michel, Scheres, Sjors Hw

“…Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different…”
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Structures of filaments from Pick’s disease reveal a novel tau protein fold by Falcon, Benjamin, Zhang, Wenjuan, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Ghetti, Bernardino, Scheres, Sjors H. W., Goedert, Michel

“…The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases 1 . Tau assemblies seem to spread…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection by El Chaar, Mira, Candotti, Daniel, Crowther, R. Anthony, Allain, Jean Pierre

“…Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small…”
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Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability by Gasparini, Laura, Anthony Crowther, R, Martin, Keith R, Berg, Nicola, Coleman, Michael, Goedert, Michel, Spillantini, Maria Grazia

“…Abstract Tau inclusions play a key role in the pathogenesis of tauopathies. Altered tau levels have been detected in retina and optic nerve of patients with…”
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Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy by Henderson, Richard, Chen, Shaoxia, Chen, James Z., Grigorieff, Nikolaus, Passmore, Lori A., Ciccarelli, Luciano, Rubinstein, John L., Crowther, R. Anthony, Stewart, Phoebe L., Rosenthal, Peter B.

“…The comparison of a pair of electron microscope images recorded at different specimen tilt angles provides a powerful approach for evaluating the quality of…”
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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau by Schweighauser, Manuel, Murzin, Alexey G, Macdonald, Jennifer, Lavenir, Isabelle, Crowther, R Anthony, Scheres, Sjors H W, Goedert, Michel

“…Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions…”
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Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein by Allen, Bridget, Ingram, Esther, Takao, Masaki, Smith, Michael J, Jakes, Ross, Virdee, Kanwar, Yoshida, Hirotaka, Holzer, Max, Craxton, Molly, Emson, Piers C, Atzori, Cristiana, Migheli, Antonio, Crowther, R. Anthony, Ghetti, Bernardino, Spillantini, Maria Grazia, Goedert, Michel

“…The identification of mutations in the Tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has made it possible to express…”
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Tau protein, the paired helical filament and Alzheimer's disease by Goedert, Michel, Klug, Aaron, Crowther, R Anthony

“…In 1906, Alzheimer described the clinical and neuropathological characteristics of the disease that was subsequently named after him. Although the paired…”
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Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies by Mellone, Manuela, Kestoras, Dimitra, Andrews, Melissa R, Dassie, Elisa, Crowther, R Anthony, Stokin, Gorazd B, Tinsley, Jon, Horne, Graeme, Goedert, Michel, Tolkovsky, Aviva M, Spillantini, Maria Grazia

“…Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative diseases, including Alzheimer's disease, progressive supranuclear…”
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Structure and Disassembly of Filaments Formed by the ESCRT-III Subunit Vps24 by Ghazi-Tabatabai, Sara, Saksena, Suraj, Short, Judith M., Pobbati, Ajaybabu V., Veprintsev, Dmitry B., Crowther, R. Anthony, Emr, Scott D., Egelman, Edward H., Williams, Roger L.

“…The ESCRT machinery mediates sorting of ubiquitinated transmembrane proteins to lysosomes via multivesicular bodies (MVBs) and also has roles in cytokinesis…”
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Fiber Diffraction of Synthetic α -synuclein Filaments Shows Amyloid-Like Cross-β Conformation by Serpell, Louise C., Berriman, John, Jakes, Ross, Goedert, Michel, Crowther, R. Anthony

“…Filamentous inclusions made of α -synuclein constitute the defining neuropathological characteristic of Parkinson's disease, dementia with Lewy bodies, and…”
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α -Synuclein in Filamentous Inclusions of Lewy Bodies from Parkinson's Disease and Dementia with Lewy Bodies by Spillantini, Maria Grazia, Crowther, R. Anthony, Jakes, Ross, Hasegawa, Masato, Goedert, Michel

“…Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of…”
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Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy by Delobel, Patrice, Lavenir, Isabelle, Fraser, Graham, Ingram, Esther, Holzer, Max, Ghetti, Bernardino, Spillantini, Maria Grazia, Crowther, R. Anthony, Goedert, Michel

“…Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the…”
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Tau Filaments from Human Brain and from in vitro Assembly of Recombinant Protein Show Cross-β Structure by Berriman, John, Serpell, Louise C., Oberg, Keith A., Fink, Anthony L., Goedert, Michel, Crowther, R. Anthony

“…Abnormal filaments consisting of hyperphosphorylated microtubule-associated protein tau form in the brains of patients with Alzheimer's disease, Down's…”
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Insights into neurodegeneration from electron microscopy studies by Crowther, R Anthony

“…Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, pose an increasingly severe burden for individuals and society in an ageing…”
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A Structural Model for Maturation of the Hepatitis B Virus Core by Alan M. Roseman, John A. Berriman, Samantha A. Wynne, Jonathan, P., Butler, G., Crowther, R. Anthony, Lamb, Robert A.

“…Hepatitis B virus, a widespread and serious human pathogen, replicates by reverse transcription of an RNA intermediate. The virus consists of an inner…”
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Cryo-EM structures of tau filaments from Alzheimer’s disease by Fitzpatrick, Anthony W. P., Falcon, Benjamin, He, Shaoda, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Crowther, R. Anthony, Ghetti, Bernardino, Goedert, Michel, Scheres, Sjors H. W.

“…Alzheimer’s disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of…”
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