Search Results - "Crown, Scott B."

Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes by Crown, Scott B, Marze, Nicholas, Antoniewicz, Maciek R

“…The branched chain amino acids (BCAA) valine, leucine and isoleucine have been implicated in a number of diseases including obesity, insulin resistance, and…”
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Cardiovascular Metabolomics by McGarrah, Robert W, Crown, Scott B, Zhang, Guo-Fang, Shah, Svati H, Newgard, Christopher B

“…Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for…”
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Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation by McDonnell, Eoin, Crown, Scott B., Fox, Douglas B., Kitir, Betül, Ilkayeva, Olga R., Olsen, Christian A., Grimsrud, Paul A., Hirschey, Matthew D.

“…Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene…”
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Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury by Yurdagul, Arif, Subramanian, Manikandan, Wang, Xiaobo, Crown, Scott B., Ilkayeva, Olga R., Darville, Lancia, Kolluru, Gopi K., Rymond, Christina C., Gerlach, Brennan D., Zheng, Ze, Kuriakose, George, Kevil, Christopher G., Koomen, John M., Cleveland, John L., Muoio, Deborah M., Tabas, Ira

“…Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is…”
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Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis by Bu, Pengcheng, Chen, Kai-Yuan, Xiang, Kun, Johnson, Christelle, Crown, Scott B., Rakhilin, Nikolai, Ai, Yiwei, Wang, Lihua, Xi, Rui, Astapova, Inna, Han, Yan, Li, Jiahe, Barth, Bradley B., Lu, Min, Gao, Ziyang, Mines, Robert, Zhang, Liwen, Herman, Mark, Hsu, David, Zhang, Guo-Fang, Shen, Xiling

“…Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the…”
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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart by Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.

“…Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major…”
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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction by Williams, Ashley S., Koves, Timothy R., Davidson, Michael T., Crown, Scott B., Fisher-Wellman, Kelsey H., Torres, Maria J., Draper, James A., Narowski, Tara M., Slentz, Dorothy H., Lantier, Louise, Wasserman, David H., Grimsrud, Paul A., Muoio, Deborah M.

“…This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring…”
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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion by White, Phillip J., Lapworth, Amanda L., McGarrah, Robert W., Kwee, Lydia Coulter, Crown, Scott B., Ilkayeva, Olga, An, Jie, Carson, Matthew W., Christopher, Bridgette A., Ball, James R., Davies, Michael N., Kjalarsdottir, Lilja, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Koves, Timothy R., Muoio, Deborah M., Brozinick, Joseph T., Gimeno, Ruth E., Brosnan, M. Julia, Rolph, Timothy P., Kraus, William E., Shah, Svati H., Newgard, Christopher B.

“…Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain…”
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Statin therapy inhibits fatty acid synthase via dynamic protein modifications by Trub, Alec G., Wagner, Gregory R., Anderson, Kristin A., Crown, Scott B., Zhang, Guo-Fang, Thompson, J. Will, Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Kulkarni, Rhushikesh A., Backos, Donald S., Meier, Jordan L., Hirschey, Matthew D.

“…Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA…”
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Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever by Yoneshiro, Takeshi, Kataoka, Naoya, Walejko, Jacquelyn M, Ikeda, Kenji, Brown, Zachary, Yoneshiro, Momoko, Crown, Scott B, Osawa, Tsuyoshi, Sakai, Juro, McGarrah, Robert W, White, Phillip J, Nakamura, Kazuhiro, Kajimura, Shingo

“…Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAAs) are…”
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Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass by Wilson, Rebecca J., Lyons, Scott P., Koves, Timothy R., Bryson, Victoria G., Zhang, Hengtao, Li, TianYu, Crown, Scott B., Ding, Jin-Dong, Grimsrud, Paul A., Rosenberg, Paul B., Muoio, Deborah M.

“…Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store…”
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Publishing 13C metabolic flux analysis studies: A review and future perspectives by Crown, Scott B., Antoniewicz, Maciek R.

“…13C-Metabolic flux analysis (13C-MFA) is a powerful model-based analysis technique for determining intracellular metabolic fluxes in living cells. It has…”
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Selection of tracers for 13C-Metabolic Flux Analysis using Elementary Metabolite Units (EMU) basis vector methodology by Crown, Scott B., Antoniewicz, Maciek R.

“…Metabolic flux analysis (MFA) is a powerful technique for elucidating in vivo fluxes in microbial and mammalian systems. A key step in 13C-MFA is the selection…”
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Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and (13)C-metabolic flux analysis by Ahn, Woo Suk, Crown, Scott B, Antoniewicz, Maciek R

“…The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. It provides precursors for the biosynthesis of nucleotides and…”
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Parallel labeling experiments and metabolic flux analysis: Past, present and future methodologies by Crown, Scott B., Antoniewicz, Maciek R.

“…Radioactive and stable isotopes have been applied for decades to elucidate metabolic pathways and quantify carbon flow in cellular systems using mass and…”
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Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles by Koves, Timothy R., Zhang, Guo-Fang, Davidson, Michael T., Chaves, Alec B., Crown, Scott B., Johnson, Jordan M., Slentz, Dorothy H., Grimsrud, Paul A., Muoio, Deborah M.

“…Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of…”
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Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding by Williams, Ashley S, Crown, Scott B, Lyons, Scott P, Koves, Timothy R, Wilson, Rebecca J, Johnson, Jordan M, Slentz, Dorothy H, Kelly, Daniel P, Grimsrud, Paul A, Zhang, Guo-Fang, Muoio, Deborah M

“…Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study questioned if the health benefits of an…”
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Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts by Crown, Scott B, Kelleher, Joanne K, Rouf, Rosanne, Muoio, Deborah M, Antoniewicz, Maciek R

“…In many forms of cardiomyopathy, alterations in energy substrate metabolism play a key role in disease pathogenesis. Stable isotope tracing in rodent heart…”
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Optimal tracers for parallel labeling experiments and 13C metabolic flux analysis: A new precision and synergy scoring system by Crown, Scott B., Long, Christopher P., Antoniewicz, Maciek R.

“…13C-Metabolic flux analysis (13C-MFA) is a widely used approach in metabolic engineering for quantifying intracellular metabolic fluxes. The precision of…”
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Resolving the TCA cycle and pentose-phosphate pathway of Clostridium acetobutylicum ATCC 824: Isotopomer analysis, in vitro activities and expression analysis by Crown, Scott B., Indurthi, Dinesh C., Ahn, Woo Suk, Choi, Jungik, Papoutsakis, Eleftherios T., Antoniewicz, Maciek R.

“…Solventogenic clostridia are an important class of microorganisms that can produce various biofuels. One of the bottlenecks in engineering clostridia stems…”
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