Search Results - "Crowley, Michael P"

Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer by Crowley, Michael J. P., Bhinder, Bhavneet, Markowitz, Geoffrey J., Martin, Mitchell, Verma, Akanksha, Sandoval, Tito A., Chae, Chang-Suk, Yomtoubian, Shira, Hu, Yang, Chopra, Sahil, Tavarez, Diamile A., Giovanelli, Paolo, Gao, Dingcheng, McGraw, Timothy E., Altorki, Nasser K., Elemento, Olivier, Cubillos-Ruiz, Juan R., Mittal, Vivek

“…IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational…”
Get full text

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy by Markowitz, Geoffrey J., Ban, Yi, Tavarez, Diamile A., Yoffe, Liron, Podaza, Enrique, He, Yongfeng, Martin, Mitchell T., Crowley, Michael J. P., Sandoval, Tito A., Gao, Dingcheng, Martin, M. Laura, Elemento, Olivier, Cubillos-Ruiz, Juan R., McGraw, Timothy E., Altorki, Nasser K., Mittal, Vivek

“…TCF1 high progenitor CD8 + T cells mediate the efficacy of immunotherapy; however, the mechanisms that govern their generation and maintenance are poorly…”
Get full text

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis by Poulos, Michael G., Ramalingam, Pradeep, Gutkin, Michael C., Kleppe, Maria, Ginsberg, Michael, Crowley, Michael J. P., Elemento, Olivier, Levine, Ross L., Rafii, Shahin, Kitajewski, Jan, Greenblatt, Matthew B., Shim, Jae-Hyuck, Butler, Jason M.

“…Haematopoietic stem cells (HSCs) reside in distinct niches within the bone marrow (BM) microenvironment, comprised of endothelial cells (ECs) and tightly…”
Get full text

Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma by Crowley, Michael J. P, Scognamiglio, Theresa, Liu, Yi-Fang, Kleiman, David A, Beninato, Toni, Aronova, Anna, Liu, He, Jhanwar, Yuliya S, Molina, Ana, Tagawa, Scott T, Bander, Neil H, Zarnegar, Rasa, Elemento, Olivier, Fahey, Thomas J

“…Context: Adrenocortical carcinoma (ACC) is a rare tumor type with a poor prognosis and few therapeutic options. Objective: Assess prostate-specific membrane…”
Get full text

Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors by Kleiman, David A., Beninato, Toni, Sultan, Samuel, Crowley, Michael J. P., Finnerty, Brendan, Kumar, Ritu, Panarelli, Nicole C., Liu, Yi-Fang, Lieberman, Michael D., Seandel, Marco, Evans, Todd, Elemento, Olivier, Zarnegar, Rasa, Fahey, Thomas J.

“…Background Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors with varying metastatic potential. The underlying…”
Get full text

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity by Song, Minkyung, Sandoval, Tito A., Chae, Chang-Suk, Chopra, Sahil, Tan, Chen, Rutkowski, Melanie R., Raundhal, Mahesh, Chaurio, Ricardo A., Payne, Kyle K., Konrad, Csaba, Bettigole, Sarah E., Shin, Hee Rae, Crowley, Michael J. P., Cerliani, Juan P., Kossenkov, Andrew V., Motorykin, Ievgen, Zhang, Sheng, Manfredi, Giovanni, Zamarin, Dmitriy, Holcomb, Kevin, Rodriguez, Paulo C., Rabinovich, Gabriel A., Conejo-Garcia, Jose R., Glimcher, Laurie H., Cubillos-Ruiz, Juan R.

“…Tumours evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function 1 – 4 . However, it remains unclear how…”
Get full text

RECOGNITION BY γ/δ T CELLS by Chien, Yueh-hsiu, Jores, Rita, Crowley, Michael P

“…In contrast with the study of αβ T cells, that of γδ T cells is relatively recent and stems from the discovery of their rearranged genes, rather than from any…”
Get full text

STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro by Aronova, Anna, Min, Irene M., Crowley, Michael J. P., Panjwani, Suraj J., Finnerty, Brendan M., Scognamiglio, Theresa, Liu, Yi-Fang, Whitsett, Timothy G., Garg, Shipra, Demeure, Michael J., Elemento, Olivier, Zarnegar, Rasa, Fahey III, Thomas J.

“…Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis and few therapeutic options. Stathmin1 (STMN1) is a cytosolic…”
Get full text

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis by Poulos, Michael G., Crowley, Michael J.P., Gutkin, Michael C., Ramalingam, Pradeep, Schachterle, William, Thomas, Jean-Leon, Elemento, Olivier, Butler, Jason M.

“…Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM), which govern the delicate balance between HSC quiescence,…”
Get full text

A Population of Murine γδ T Cells That Recognize an Inducible MHC Class Ib Molecule by Crowley, Michael P., Fahrer, Aude M., Baumgarth, Nicole, Hampl, Johannes, Gutgemann, Ines, Teyton, Luc, Chien, Yueh-hsiu

“…Although γδ T cells are implicated in regulating immune responses, γδ T cell-ligand pairs that could mediate such regulatory functions have not been…”
Get full text

The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the γδ T Cell, G8 by Crowley, Michael P., Reich, Ziv, Mavaddat, Nasim, Altman, John D., Chien, Yueh-hsiu

“…Recent studies have shown that many nonclassical major histocompatibility complex (MHC) (class Ib) molecules have distinct antigen-binding capabilities,…”
Get full text

Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival by Markowitz, Geoffrey J, Havel, Lauren S, Crowley, Michael Jp, Ban, Yi, Lee, Sharrell B, Thalappillil, Jennifer S, Narula, Navneet, Bhinder, Bhavneet, Elemento, Olivier, Wong, Stephen Tc, Gao, Dingcheng, Altorki, Nasser K, Mittal, Vivek

“…Success of immune checkpoint inhibitors in advanced non-small-cell lung cancer (NSCLC) has invigorated their use in the neoadjuvant setting for early-stage…”
Get full text

Crystal Structure of γδ T Cell Receptor Ligand T22: A Truncated MHC-like Fold by Wingren, Christer, Crowley, Michael P., Degano, Massimo, Chien, Yueh-hsiu, Wilson, Ian A.

“…Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class lb proteins that bind to certain γδ T cell receptors (TCRs) in…”
Get full text

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the γδ T-cell ligand T10 by Rudolph, Markus G., Wingren, Christer, Crowley, Michael P., Chien, Yueh-hsiu, Wilson, Ian A.

“…T10 is a non‐classical class Ib‐like major histocompatibility complex (MHC) cell‐surface antigen which binds directly to certain γδ T‐cell receptors in the…”
Get full text

The Specificity of a Weak γδ TCR Interaction Can Be Modulated by the Glycosylation of the Ligand by Hampl, Johannes, Schild, Hansjörg, Litzenberger, Christa, Baron, Miriam, Crowley, Michael P., Chien, Yueh-hsiu

“…The γδ T cell clone LBK5 recognizes the MHC molecule IEk. Here, we demonstrate that the affinity of this interaction is weaker than those typically reported…”
Get full text

A population of murine (gamma delta) T cells that recognize an inducible MHC class lb molecule by Crowley, Michael P, Fahrer, Ude M, Baumgarth, Nicole, Hampl, Johannes

“…Although gammabeta T cells are implicated in regulating immune responses, gammabeta T ceil-tigand pairs that could mediate such regulatory functions have not…”
Get full text

Endothelial-specific inhibition of NF-[kappa]B enhances functional haematopoiesis by Poulos, Michael G, Ramalingam, Pradeep, Gutkin, Michael C, Kleppe, Maria, Ginsberg, Michael, Crowley, Michael J P, Elemento, Olivier, Levine, Ross L, Rafii, Shahin, Kitajewski, Jan, Greenblatt, Matthew B, Shim, Jae-hyuck, Butler, Jason M

“…Haematopoietic stem cells (HSCs) reside in distinct niches within the bone marrow (BM) microenvironment, comprised of endothelial cells (ECs) and tightly…”
Get full text

Crystal Structure of a [Gamma][Delta] T Cell Receptor Ligand T22: A Truncated MHC-Like Fold by Wingren, Christer, Crowley, Michael P, Degano, Massimo, Chien, Yueh-hsiu, Wilson, Ian A

“…Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class lb proteins that bind to certain [Gamma][Delta] T cell…”
Get full text

Crystal Structure of a [Gamma]Δ T Cell Receptor Ligand T22: A Truncated MHC-Like Fold by Wingren, Christer, Crowley, Michael P, Degano, Massimo, Chien, Yueh-hsiu, Wilson, Ian A

“…Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class lb proteins that bind to certain [Gamma]Δ T cell receptors…”
Get full text

A Population of Murine [Gamma][Delta] T Cells That Recognize an Inducible MHC Class Ib Molecule by Crowley, Michael P, Fahrer, Aude M, Baumgarth, Nicole, Hampl, Johannes, Gutgemann, Ines, Teyton, Luc, Chien, Yueh-hsiu

“…Although [Gamma][Delta] T cells are implicated in regulating immune responses, [Gamma][Delta] T cell-ligand pairs that could mediate such regulatory functions…”
Get full text