Search Results - "Crowell, Thomas A."

Painful abdominal mass in a pregnant patient by Naylor, Jason F, Harper, Hillary M, Crowell, Thomas A

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Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life by Bhatia, Sapna, Qualls, Clifford, Crowell, Thomas A, Arynchyn, Alexander, Thyagarajan, Bharat, Smith, Lewis J, Kalhan, Ravi, Jacobs, David R, Kramer, Holly, Duprez, Daniel, Celli, Bartolome, Sood, Akshay

“…IntroductionChronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by…”
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Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships by Howbert, J. Jeffry, Grossman, C. Sue, Crowell, Thomas A, Rieder, Brent J, Harper, Richard W, Kramer, Kenneth E, Tao, Eddie V, Aikins, James, Poore, Gerald A

“…A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted…”
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Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogs of trioxifene, [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl[methanone by Jones, Charles D, Blaszczak, Larry C, Goettel, Mary E, Suarez, Tulio, Crowell, Thomas A, Mabry, Thomas E, Ruenitz, Peter C, Srivatsan, V

“…Benzothiophenes 3 and 4, derived from the acrylophenone antiestrogen trioxifene (2), are characterized by high estrogen receptor (ER) affinity and low residual…”
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3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists by Hipskind, Philip A, Howbert, J. Jeffry, Bruns, Robert F, Cho, Steven S. Y, Crowell, Thomas A, Foreman, Mark M, Gehlert, Donald R, Iyengar, Smriti, Johnson, Kirk W, Krushinski, Joseph H, Li, Dominic L, Lobb, Karen L, Mason, Norman R, Muehl, Brian S, Nixon, James A, Phebus, Lee A, Regoli, Domenico, Simmons, Rosa M, Threlkeld, Penny G, Waters, Diane C, Gitter, Bruce D

“…Early structure−activity studies on racemic tryptophan ester and amide NK-1 antagonists 5−7 led to the discovery that the potency of the series could be…”
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Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogs by Flaugh, Michael E, Crowell, Thomas A, Clemens, James A, Sawyer, Barry D

“…A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1…”
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Acid-catalyzed annelation of .alpha.-alkylaldehydes and .alpha.,.beta.-unsaturated ketones. A one-pot synthesis of 4,4-dimethyl-2-cyclohexen-1-one by Flaugh, Michael E, Crowell, Thomas A, Farlow, Diane S

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A systematic study of P1–P3 spanning sidechains for the inhibition of HIV-1 protease by Kaldor, Stephen W., Appelt, Krzysztof, Fritz, James E., Hammond, Marlys, Crowell, Thomas A., Baxter, Angela J., Hatch, Steven D., Wiskerchen, MaryAnn, Muesing, Mark A.

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A systematic study of P 1–P 3 spanning sidechains for the inhibition of HIV-1 protease by Kaldor, Stephen W., Appelt, Krzysztof, Fritz, James E., Hammond, Marlys, Crowell, Thomas A., Baxter, Angela J., Hatch, Steven D., Wiskerchen, MaryAnn, Muesing, Mark A.

“…Using information obtained from the co-crystal structure of an initial peptidomimetic lead complexed with HIV-1 protease, a series of inhibitors was…”
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3-Sulfonyl-1-carba-1-dethiacephems by Crowell, Thomas A., Halliday, Basil D., McDonald, John H., Indelicato, Joseph M., Pasini, Carol E., Wu, Ernie C. Y.

“…The stability of the 1-carba-1-dethiacephalosporin framework has allowed the synthesis of a range of 3-sulfonyl-1-carba-1-dethiacephems unavailable for a…”
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