Search Results - "Crowe, Miriam C."

Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs by Young, Robert J., Campbell, Matthew, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Convery, Máire A., Crowe, Miriam C., Dayal, Satish, Diallo, Hawa, Kelly, Henry A., Paul King, N., Kleanthous, Savvas, Mason, Andrew M., Mordaunt, Jackie E., Patel, Champa, Pateman, Anthony J., Senger, Stefan, Shah, Gita P., Smith, Paul W., Watson, Nigel S., Weston, Helen E., Zhou, Ping

“…The synthesis and profiles of a series of fXa inhibitors with acyclic alanyl amide P4 motifs is described, which includes potent examples showing highly…”
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Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2 R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor by Young, Robert J., Alderton, Wendy, Angell, Anthony D.R., Beswick, Paul J., Brown, David, Chambers, C. Lynn, Crowe, Miriam C., Dawson, John, Hamlett, Christopher C.F., Hodgson, Simon T., Kleanthous, Savvas, Knowles, Richard G., Russell, Linda J., Stocker, Richard, Woolven, James M.

“…The exploration of heterocyclic carboxamidines as iNOS inhibitors led to the identification of (2 R)-2-pyrrolidinecarboxamidine as a potent and selective…”
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