Search Results - "Crowe, Kelly E."

Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans by Zygmunt, Deborah A., Singhal, Neha, Kim, Mi-Lyang, Cramer, Megan L., Crowe, Kelly E., Xu, Rui, Jia, Ying, Adair, Jessica, Martinez-Pena y Valenzuela, Isabel, Akaaboune, Mohammed, White, Peter, Janssen, Paulus M., Martin, Paul T.

“…Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate changes in skeletal myofibers and the cells that contact them,…”
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Comparison of Lectins as Staining Biomarkers for GNE Myopathy Gene Therapy by Crowe, Kelly E.

“…GNE myopathy (GNEM) is an autosomal recessive disease in which mutations in the GNEgene lead to skeletal muscle weakness and progressive wasting. GNE encodes…”
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Lectin Staining for the Detection of In Vitro Sialic Acid Alterations by Roth, Mackenzie, Crowe, Kelly E.

“…GNE Myopathy (GNEM) is a rare disease caused by a mutation in the UDP‐N‐acetylglucosamine 2‐epimerase/N‐acetylmannosamine kinase (GNE) gene, which catalyzes…”
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Reduced Sarcolemmal Membrane Repair Exacerbates Striated Muscle Pathology in a Mouse Model of Duchenne Muscular Dystrophy by Paleo, Brian J, McElhanon, Kevin E, Bulgart, Hannah R, Banford, Kassidy K, Beck, Eric X, Sattler, Kristina M, Goines, Briana N, Ratcliff, Shelby L, Crowe, Kelly E, Weisleder, Noah

“…Duchenne muscular dystrophy (DMD) is a common X-linked degenerative muscle disorder that involves mutations in the DMD gene that frequently reduce the…”
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An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque by Xu, Rui, Jia, Ying, Zygmunt, Deborah A., Cramer, Megan L., Crowe, Kelly E., Shao, Guohong, Maki, Agatha E., Guggenheim, Haley N., Hood, Benjamin C., Griffin, Danielle A., Peterson, Ellyn, Bolon, Brad, Cheatham, John P., Cheatham, Sharon L., Flanigan, Kevin M., Rodino-Klapac, Louise R., Chicoine, Louis G., Martin, Paul T.

“…Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy. Here…”
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Lectin Biomarker Development in a Mouse Model of GNE Myopathy by Bradley, Kara E., Crowe, Kelly E.

“…GNE Myopathy (GNEM) is a rare autosomal recessive disease that causes progressive muscle wasting. GNEM occurs due to mutations in the GNE gene that encodes a…”
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C. elegansAttraction Learning in casy‐1Mutants by Gilpin, Megan E., Crowe, Kelly E.

“…C. eleganshave a simple nervous system with approximately 300 neurons and exhibit well‐documented learning‐specific behaviors. Several genetic mutations, such…”
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Assessment of Sialic Acid Levels in an In Vitro Model of Muscle Atrophy by Poynter, Megan N., Crowe, Kelly E.

“…Muscular atrophy is a loss of muscle tissue that can occur due to inactivity or underlying disease processes. Studies have shown that muscle pathology may be…”
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Comparison of Serum rAAV Serotype-Specific Antibodies in Patients with Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Inclusion Body Myositis, or GNE Myopathy by Zygmunt, Deborah A, Crowe, Kelly E, Flanigan, Kevin M, Martin, Paul T

“…Recombinant adeno-associated virus (rAAV) is a commonly used gene therapy vector for the delivery of therapeutic transgenes in a variety of human diseases, but…”
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Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah−/−mdx Mice by Martin, Paul T., Kawanishi, Kunio, Ashbrook, Anna, Golden, Bethannie, Samraj, Annie, Crowe, Kelly E., Zygmunt, Deborah A., Okerblom, Jonathan, Yu, Hai, Maki, Agatha, Diaz, Sandra, Chen, Xi, Janssen, Paul M.L., Varki, Ajit

“…Humans cannot synthesize the common mammalian sialic acid N -glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the…”
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Visualizing Muscle Sialic Acid Expression in the GNED207VTgGne-/- Cmah-/- Model of GNE Myopathy: A Comparison of Dietary and Gene Therapy Approaches by Crowe, Kelly E, Zygmunt, Deborah A, Heller, Kristin, Rodino-Klapac, Louise, Noguchi, Satoru, Nishino, Ichizo, Martin, Paul T

“…GNE myopathy (GNEM) is a rare, adult-onset, inclusion body myopathy that results from mutations in the GNE gene. GNE encodes UDP-GlcNAc epimerase/ManNAc-6…”
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N-terminal α Dystroglycan (αDG-N): A Potential Serum Biomarker for Duchenne Muscular Dystrophy by Crowe, Kelly E, Shao, Guohong, Flanigan, Kevin M, Martin, Paul T

“…Duchenne Muscular Dystrophy (DMD) is a severe, progressive, neuromuscular disorder of childhood. While a number of serum factors have been identified as…”
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Lectin Staining Biomarkers for Gene Therapy in GNE Myopathy by Crowe, Kelly E.

“…Abstract only GNE myopathy (GNEM) is an autosomal recessive disease characterized by muscle wasting and weakness. This disease is caused by mutations in the…”
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C. elegans Attraction Learning in casy‐1 Mutants by Gilpin, Megan E., Crowe, Kelly E.

“…Abstract only C. elegans have a simple nervous system with approximately 300 neurons and exhibit well‐documented learning‐specific behaviors. Several genetic…”
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Assessing Sialic Acid Uptake in an In Vitro Model of GNE Myopathy by Goines, Briana N., Sattler, Kristina M., Crowe, Kelly E.

“…Abstract only Mutations in the GNE gene leads to GNE myopathy (GNEM), a rare autosomal disease that causes skeletal muscle weakness. The GNE gene encodes an…”
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Assessing the Degree of Differentiation in Myotubes derived from Patients with GNE Myopathy by Sattler, Kristina M., Busam, Sara, Crowe, Kelly E.

“…Abstract only GNE Myopathy (GNEM) is an extremely rare autosomal recessive disease that causes muscle wasting due to mutations in the GNE gene. The GNE protein…”
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Sialic Acid Alterations in Mouse Models of Atrophy and Hypertrophy by Busam, Sara, Goines, Briana N., Weisleder, Noah L., Crowe, Kelly E.

“…Abstract only Sialic acids (SAs) are negatively charged nine‐carbon sugars that are typically found at the ends of glycan chains on glycolipids and…”
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Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmahmdx Mice by Martin, Paul T., Kawanishi, Kunio, Ashbrook, Anna, Golden, Bethannie, Samraj, Annie, Crowe, Kelly E., Zygmunt, Deborah A., Okerblom, Jonathan, Yu, Hai, Maki, Agatha, Diaz, Sandra, Chen, Xi, Janssen, Paul M.L., Varki, Ajit

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An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK. GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque by Xu, Rui, Jia, Ying, Zygmunt, Deborah A, Cramer, Megan L, Crowe, Kelly E, Shao, Guohong, Maki, Agatha E, Guggenheim, Haley N, Hood, Benjamin C, Griffin, Danielle A, Peterson, Ellyn, Bolon, Brad, Cheatham, John P, Cheatham, Sharon L, Flanigan, Kevin M, Rodino-Klapac, Louise R, Chicoine, Louis G, Martin, Paul T

“…Recombinant adeno-associated virus (rAAV)rh74.MCK. is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy. Here we…”
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