Search Results - "Crowder, Roslyn N"

The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death by Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

“…TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapy that selectively targets cancer cell death while non-malignant cells remain viable…”
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Correction: First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent by Allen, Joshua E, Crowder, Roslyn N, El-Deiry, Wafik S

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First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent by Allen, Joshua E, Crowder, Roslyn N, Crowder, Roslyn, El-Deiry, Wafik S

“…We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is currently in clinical trials in…”
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B lymphocytes are resistant to death receptor 5-induced apoptosis by Crowder, Roslyn N, Zhao, Hong, Chatham, W. Winn, Zhou, Tong, Carter, Robert H

“…Abstract Death Receptor 5 (DR5) induces apoptosis in various types of cells and is a potential therapeutic target. We have investigated whether targeting DR5…”
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Abstract 2938: Altered caspase-8 protein expression and activity in TRAIL-resistant normal human fibroblasts by Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

“…Abstract TNF-related apoptosis-inducing ligand (TRAIL)-mediated cell death is currently being utilized in newly developed cancer therapies. The molecular basis…”
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Abstract 252: Altered caspase-8 localization and decreased caspase-8 sumoylation in TRAIL-resistant normal human fibroblasts by Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

“…Abstract TNF-related apoptosis-inducing ligand (TRAIL)-mediated cell death is currently being utilized in newly developed cancer therapies. The molecular basis…”
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Abstract 4095: Decreased caspase 8 protein expression and incomplete caspase 3 activation in TRAIL-resistant normal human fibroblasts and epithelial cells by Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

“…Abstract TNF-related apoptosis-inducing ligand (TRAIL)-mediated cell death is currently being utilized in newly developed cancer therapies. The molecular basis…”
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Abstract 1042: Diminished caspase 8 and c-Myc protein expression in human fibroblasts provides insight into normal cell resistance to TRAIL-mediated apoptosis by Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.

“…Abstract TNF-related apoptosis-inducing ligand (TRAIL)-mediated cell death is currently being exploited in clinical trials for cancer therapy. However, the…”
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