Bacterial toxicity testing and antibacterial activity of parabens

Bacterial toxicity testing and antibacterial activity of parabens

Parabens are used because of their antimicrobial effects, yet they have multiple adverse effects. The aim of this work was to evaluate the bactericidal activity and bacterial toxicity of the most common parabens: methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylpar...

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Bibliographic Details
Published in:Toxicological and environmental chemistry Vol. 99; no. 5-6; pp. 858 - 868
Main Authors: Crovetto, Sara I., Moreno, Elena, Dib, Amira L., Espigares, Miguel, Espigares, Elena
Format: Journal Article
Language:English
Published: Abingdon Taylor & Francis 03-07-2017
Taylor & Francis Ltd
Subjects:
Acute toxicity
Antibacterial activity
Bacteria
Bactericidal activity
Bactericidal effect
Dilution
dilution-neutralization
disinfectant
E coli
Escherichia coli
Neutralization
parabens
Propyl paraben
Side effects
Staphylococcus aureus
Toxicity
Toxicity testing
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Summary:Parabens are used because of their antimicrobial effects, yet they have multiple adverse effects. The aim of this work was to evaluate the bactericidal activity and bacterial toxicity of the most common parabens: methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben and phenylparaben. The bactericidal action was evaluated by means of the dilution-neutralization method against Escherichia coli and Staphylococcus aureus, and the biotest of inhibition of growth of E. coli was applied for the bacterial toxicity assay. Bactericidal concentrations were reached only for propylparaben, butylparaben and isobutylparaben. The toxicity study showed methylparaben to be the least toxic, whereas the most toxic one was phenylparaben. It can be concluded that the disinfectant activity of the parabens studied is insignificant against S. aureus and E. coli. Acute toxicity is very low, and the inhibitory effect is weak. Our results provide information about the risk-benefit balance of parabens use.
ISSN:0277-2248
1029-0486
DOI:10.1080/02772248.2017.1300905