Search Results - "Crouthamel, Matthew H"

Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate by Shanahan, Catherine M, Crouthamel, Matthew H, Kapustin, Alexander, Giachelli, Cecilia M

“…Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney disease (CKD) patients. Dysregulation of calcium (Ca) and…”
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Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells by Chavkin, Nicholas W., Chia, Jia Jun, Crouthamel, Matthew H., Giachelli, Cecilia M.

“…Vascular calcification (VC) is prevalent in chronic kidney disease and elevated serum inorganic phosphate (Pi) is a recognized risk factor. The type III…”
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Transport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition by Hanna, Imad, Alexander, Natalya, Crouthamel, Matthew H., Davis, John, Natrillo, Adrienne, Tran, Phi, Vapurcuyan, Arpine, Zhu, Bing

“…1. The potential for drug-drug interactions of LCZ696 (a novel, crystalline complex comprising sacubitril and valsartan) was investigated in vitro. 2…”
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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification by Scialla, Julia J, Lau, Wei Ling, Reilly, Muredach P, Isakova, Tamara, Yang, Hsueh-Ying, Crouthamel, Matthew H, Chavkin, Nicholas W, Rahman, Mahboob, Wahl, Patricia, Amaral, Ansel P, Hamano, Takayuki, Master, Stephen R, Nessel, Lisa, Chai, Boyang, Xie, Dawei, Kallem, Radhakrishna R, Chen, Jing, Lash, James P, Kusek, John W, Budoff, Matthew J, Giachelli, Cecilia M, Wolf, Myles

“…Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating…”
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Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2 by Crouthamel, Matthew H, Lau, Wei Ling, Leaf, Elizabeth M, Chavkin, Nicholas W, Wallingford, Mary C, Peterson, Danielle F, Li, Xianwu, Liu, Yonggang, Chin, Michael T, Levi, Moshe, Giachelli, Cecilia M

“…OBJECTIVE—Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was…”
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Development and characterization of transgenic mouse models for conditional gene knockout in the blood–brain and blood-CSF barriers by Crouthamel, Matthew H, Kelly, Edward J, Ho, Rodney J. Y

“…For many CNS acting drugs, penetration into the central nervous system (CNS) is limited by the blood-CNS-barriers. In an effort to quantitate the role of the…”
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MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents by Woodahl, Erica L, Crouthamel, Matthew H, Bui, Tot, Shen, Danny D, Ho, Rodney J. Y

“…Purpose P-glycoprotein (P-gp), encoded by MDR1 (or ABCB1), is important in anticancer drug delivery and resistance. We evaluated alterations in P-gp-mediated…”
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A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells by Crouthamel, Matthew H, Wu, Daniel, Yang, Ziping, Ho, Rodney J Y

“…The human multidrug resistance gene MDR1 encodes the protein product P-glycoprotein (P-gp). P-gp is an integral membrane protein which mediates ATP-dependent…”
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A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions by Crouthamel, Matthew H., Wu, Daniel, Yang, Ziping, Ho, Rodney J. Y.

“…P-glycoprotein (P-gp) is a membrane-bound transporter protein that is encoded by the human multidrug resistance gene MDR1 ( ABCB1 ). P-gp recognizes a wide…”
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