Search Results - "Crouch, J."

Ribonuclease H: the enzymes in eukaryotes by Cerritelli, Susana M, Crouch, Robert J

“…Ribonucleases H are enzymes that cleave the RNA of RNA/DNA hybrids that form during replication and repair and which could lead to DNA instability if they were…”
Get full text

RNase H2-Initiated Ribonucleotide Excision Repair by Sparks, Justin L., Chon, Hyongi, Cerritelli, Susana M., Kunkel, Thomas A., Johansson, Erik, Crouch, Robert J., Burgers, Peter M.

“…Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies of about 2 per kb, which makes them by far the most abundant form…”
Get full text

The Populus holobiont: dissecting the effects of plant niches and genotype on the microbiome by Cregger, M A, Veach, A M, Yang, Z K, Crouch, M J, Vilgalys, R, Tuskan, G A, Schadt, C W

“…Microorganisms serve important functions within numerous eukaryotic host organisms. An understanding of the variation in the plant niche-level microbiome, from…”
Get full text

The Balancing Act of Ribonucleotides in DNA by Cerritelli, Susana M., Crouch, Robert J.

“…The abundance of ribonucleotides in DNA remained undetected until recently because they are efficiently removed by the ribonucleotide excision repair (RER)…”
Get full text

RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice by Pokatayev, Vladislav, Hasin, Naushaba, Chon, Hyongi, Cerritelli, Susana M, Sakhuja, Kiran, Ward, Jerrold M, Morris, H Douglas, Yan, Nan, Crouch, Robert J

“…The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins,…”
Get full text

Therapeutic Redistribution of Metal Ions To Treat Alzheimer’s Disease by Crouch, Peter J, Barnham, Kevin J

“…Currently, therapeutics that modify Alzheimer’s disease (AD)are not available. Increasing age is the primary risk factor for AD and due to an aging global…”
Get full text

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease by Southon, Adam, Szostak, Kathryn, Acevedo, Karla M., Dent, Krista A., Volitakis, Irene, Belaidi, Abdel A., Barnham, Kevin J., Crouch, Peter J., Ayton, Scott, Donnelly, Paul S., Bush, Ashley I.

“…Background and Purpose Diacetyl‐bis(4‐methyl‐3‐thiosemicarbazonato)copperII (CuII(atsm)) ameliorates neurodegeneration and delays disease progression in mouse…”
Get full text

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants by Crouch, Daniel J. M., Bodmer, Walter F.

“…The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was…”
Get full text

Frontline Science: A reduction in DHA‐derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody by Crouch, Miranda J., Kosaraju, Rasagna, Guesdon, William, Armstrong, Michael, Reisdorph, Nichole, Jain, Raghav, Fenton, Jenifer, Shaikh, Saame Raza

“…Obesity dysregulates B cell populations, which contributes toward poor immunological outcomes. We previously reported that differing B cell subsets are lowered…”
Get full text

Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis by Nowotny, Marcin, Gaidamakov, Sergei A., Crouch, Robert J., Yang, Wei

“…RNase H belongs to a nucleotidyl-transferase superfamily, which includes transposase, retroviral integrase, Holliday junction resolvase, and RISC nuclease…”
Get full text

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation by Walker, Adam K, Soo, Kai Y, Sundaramoorthy, Vinod, Parakh, Sonam, Ma, Yi, Farg, Manal A, Wallace, Robyn H, Crouch, Peter J, Turner, Bradley J, Horne, Malcolm K, Atkin, Julie D

“…In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA binding protein 43 (TDP-43) accumulates in the cytoplasm of affected…”
Get full text

RNase H2-RED carpets the path to eukaryotic RNase H2 functions by Cerritelli, Susana M., Crouch, Robert J.

“…Eukaryotic RNases H2 have dual functions in initiating the removal of ribonucleoside monophosphates (rNMPs) incorporated by DNA polymerases during DNA…”
Get full text

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach by Richardson, Tom G., Crouch, Daniel J. M., Power, Grace M., Morales-Berstein, Fernanda, Hazelwood, Emma, Fang, Si, Cho, Yoonsu, Inshaw, Jamie R. J., Robertson, Catherine C., Sidore, Carlo, Cucca, Francesco, Rich, Steven S., Todd, John A., Davey Smith, George

“…The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D)…”
Get full text

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection by Kosaraju, Rasagna, Guesdon, William, Crouch, Miranda J, Teague, Heather L, Sullivan, E Madison, Karlsson, Erik A, Schultz-Cherry, Stacey, Gowdy, Kymberly, Bridges, Lance C, Reese, Lauren R, Neufer, P Darrell, Armstrong, Michael, Reisdorph, Nichole, Milner, J Justin, Beck, Melinda, Shaikh, Saame Raza

“…Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is…”
Get full text

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD by Williams, Jared R, Trias, Emiliano, Beilby, Pamela R, Lopez, Nathan I, Labut, Edwin M, Bradford, C. Samuel, Roberts, Blaine R, McAllum, Erin J, Crouch, Peter J, Rhoads, Timothy W, Pereira, Cliff, Son, Marjatta, Elliott, Jeffrey L, Franco, Maria Clara, Estévez, Alvaro G, Barbeito, Luis, Beckman, Joseph S

“…Abstract Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration…”
Get full text

A Comparison of the Cell Phone Driver and the Drunk Driver by Strayer, David L., Drews, Frank A., Crouch, Dennis J.

“…Objective: The objective of this research was to determine the relative impairment associated with conversing on a cellular telephone while driving…”
Get full text

Genetic regulation of RNA splicing in human pancreatic islets by Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J M, Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L, Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francois, Todd, John A, Piemonti, Lorenzo, Ferrer, Jorge

“…Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely…”
Get full text

Analysis of overlapping genetic association in type 1 and type 2 diabetes by Inshaw, Jamie R. J., Sidore, Carlo, Cucca, Francesco, Stefana, M. Irina, Crouch, Daniel J. M., McCarthy, Mark I., Mahajan, Anubha, Todd, John A.

“…Aims/hypothesis Given the potential shared aetiology between type 1 and type 2 diabetes, we aimed to identify any genetic regions associated with both…”
Get full text

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis by Crouch, Peter J

“…Diagnostic imaging for amyotrophic lateral sclerosis (ALS) has the potential to alleviate elements of uncertainty associated with the current diagnostic…”
Get full text

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication by Holmes, J. Bradley, Gokhan Akman, Stuart R. Wood, Kiran Sakhuja, Susana M. Cerritelli, Chloe Moss, Mark R. Bowmaker, Howard T. Jacobs, Robert J. Crouch, Ian J. Holt

“…Encoding ribonuclease H1 (RNase H1) degrades RNA hybridized to DNA, and its function is essential for mitochondrial DNA maintenance in the developing mouse…”
Get full text