Neuropsychological and behavioral effects of postnatal dexamethasone in extremely low birth weight preterm children at early school age

Objective: To study postnatal dexamethasone treatment effects on cognitive, neuropsychological and behavioral functioning at early school age in preterm children. Study Design: We recruited 222 children born between 1998 and 2003: 114 extremely low birth weight (<1000 g; 60 dexamethasone-treated;...

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Bibliographic Details
Published in:	Journal of perinatology Vol. 32; no. 2; pp. 139 - 146
Main Authors:	Crotty, K C, Ahronovich, M D, Baron, I S, Baker, R, Erickson, K, Litman, F R
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-02-2012 Nature Publishing Group
Subjects:	Age Behavior Birth Weight Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - diagnosis Bronchopulmonary Dysplasia - drug therapy Child Child Behavior Disorders - epidemiology Child Behavior Disorders - etiology Child Behavior Disorders - physiopathology Children Cognition Cognitive ability Cohort Studies Complications and side effects Development Developmental Disabilities - epidemiology Developmental Disabilities - etiology Developmental Disabilities - physiopathology Dexamethasone Dexamethasone - adverse effects Dexamethasone - therapeutic use Dosage and administration Drug therapy Executive Function Female Gestational Age Humans Infant, Extremely Low Birth Weight Infant, Newborn Infants Low birth weight Lung diseases Male Mathematical analysis Medicine Medicine & Public Health Memory Motor skill Multivariate Analysis Neuropsychological Tests Neuropsychology Newborn babies original-article Patient outcomes Pediatric Surgery Pediatrics Postnatal Care - methods Pregnancy Premature babies Premature Birth Reference Values Regression Analysis Retrospective Studies Risk Assessment Sensorimotor integration Sociodemographics Socioeconomic Factors Steroids Term Birth United States > US chronic lung disease glucocorticoids cognition neurodevelopment bronchopulmonary dysplasia
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Summary:	Objective: To study postnatal dexamethasone treatment effects on cognitive, neuropsychological and behavioral functioning at early school age in preterm children. Study Design: We recruited 222 children born between 1998 and 2003: 114 extremely low birth weight (<1000 g; 60 dexamethasone-treated; 54 untreated) and 108 term-born. Data were analyzed using multivariate methods. Result: Preterm performed below term-born on all measures. Dexamethasone-treated performed below dexamethasone-untreated in immediate visual memory, visual-motor integration, mathematical skill and motor dexterity. However, stepwise regression indicated that medical and sociodemographic factors other than dexamethasone contributed to preterm group differences. Conclusion: Dexamethasone alone does not explain neurocognitive impairment in preterm children. Medical and sociodemographic factors (illness severity, male gender and parental education) are influential. Prospective longitudinal neuropsychological and behavioral study from preschool to school age that considers medical and sociodemographic variables will best address effects of dexamethasone exposure.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0743-8346 1476-5543
DOI:	10.1038/jp.2011.62