Search Results - "Crottogini, Alberto"

Promoting early neovascularization by allotransplanted adipose-derived Muse cells in an ovine model of acute myocardial infarction by Castillo, Martha G, Peralta, Tomás M, Locatelli, Paola, Velazquez, Candela, Herrero, Yamila, Crottogini, Alberto J, Olea, Fernanda D, Cuniberti, Luis A

“…Recent preclinical studies have demonstrated that bone marrow (BM)-derived Muse cells have a homing mechanism to reach damaged cardiac tissue while also being…”
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Gene Therapy: Targeting Cardiomyocyte Proliferation to Repopulate the Ischemic Heart by López, Ayelén Emilce, Bauzá, María del Rosario, Cuniberti, Luis, Crottogini, Alberto José, Olea, Fernanda Daniela, Locatelli, Paola

“…Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic…”
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Effect of Intramyocardial Administration of Baculovirus Encoding the Transcription Factor Tbx20 in Sheep With Experimental Acute Myocardial Infarction by Del Bauzá, María Rosario, López, Ayelén Emilce, Simonin, Jorge Alejandro, Cimbaro, Francisco Stefano, Scharn, Agustina, Castro, Araceli, Silvestro, Cintia Virginia, Cuniberti, Luis Alberto, Crottogini, Alberto José, Belaich, Mariano Nicolás, Locatelli, Paola, Olea, Fernanda Daniela

“…Gene therapy has been proposed as a strategy to induce cardiac regeneration following acute myocardial infarction (AMI). Given that Tbx20, a transcription…”
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Impact of early post-stress 99mTc sestamibi ECG-gated SPECT myocardial perfusion imaging on the detection of ischemic LV dyssynchrony: an early step in the stunning cascade by Cortés, Claudia Mariana, Aramayo G, E. Natalia, Barboza, Paula Elizabeth, Crottogini, Alberto, Embon, Mario Alberto

“…Transient alterations in ventricular conduction and synchronized cardiac performance have been reported in experimental models of myocardial ischemia. In…”
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Targeting the Cardiomyocyte Cell Cycle for Heart Regeneration by Locatelli, Paola, Giménez, Carlos Sebastián, Vega, Martín Uranga, Crottogini, Alberto, Belaich, Mariano Nicolás

“…Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and…”
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In silico performance analysis of web tools for CRISPRa sgRNA design in human genes by Nuñez Pedrozo, Cristian N., Peralta, Tomás M., Olea, Fernanda D., Locatelli, Paola, Crottogini, Alberto J., Belaich, Mariano N., Cuniberti, Luis A.

“…Angiogenic gene overexpression has been the main strategy in numerous vascular regenerative gene therapy projects. However, most have failed in clinical…”
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Effect of intramuscular baculovirus encoding mutant hypoxia-inducible factor 1-alpha on neovasculogenesis and ischemic muscle protection in rabbits with peripheral arterial disease by Giménez, Carlos S., Castillo, Martha G., Simonin, Jorge A., Núñez Pedrozo, Cristian N., Pascuali, Natalia, Bauzá, María del Rosario, Locatelli, Paola, López, Ayelén E., Belaich, Mariano N., Mendiz, Alfredo O., Crottogini, Alberto J., Cuniberti, Luis A., Olea, Fernanda D.

“…Peripheral arterial disease (PAD) is a progressive, disabling ailment for which no effective treatment exists. Gene therapy-mediated neovascularization has…”
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Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia‐Inducible Factor 1‐α (HIF1‐α) in an Ovine Model of Acute Myocardial Infarction by Hnatiuk, Anna P., Ong, Sang‐Ging, Olea, Fernanda D., Locatelli, Paola, Riegler, Johannes, Lee, Won Hee, Jen, Cheng Hao, De Lorenzi, Andrea, Giménez, Carlos S., Laguens, Rubén, Wu, Joseph C., Crottogini, Alberto

“…Background Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic…”
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HIGH-DOSE PLASMID-MEDIATED VASCULAR ENDOTHELIAL GROWTH FACTOR GENE TRANSFER IN PATIENTS WITH SEVERE CORONARY ARTERY DISEASE (GENESIS-I). SIX MONTHS RESULTS OF THE FIRST PHASE I LATIN AMERICAN TRIAL OF GENE THERAPY IN MYOCARDIAL ISCHEMIA by Favaloro, Liliana Ethel, Diez, Mirta, Mendiz, Oscar, Valdivieso, Leon, Bercovich, Andres, Criscuolo, Marcelo E, Janavel, Gustavo Vera, Crottogini, Alberto J

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Cardiac regeneration: the gene therapy approach by Laguens, Rubén P, Crottogini, Alberto J

“…Ischemic heart disease often results in myocardial infarction, after which surviving tissue undergoes remodeling. Unfortunately, the regenerative capacity of…”
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Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans by Locatelli, Paola, Olea, Fernanda D, De Lorenzi, Andrea, Salmo, Fabián, Vera Janavel, Gustavo L, Hnatiuk, Anna P, Guevara, Eduardo, Crottogini, Alberto J

“…Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to…”
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Cardiomyocytes of Chronically Ischemic Pig Hearts Express the MDR-1 Gene-encoded P-glycoprotein by Lazarowski, Alberto J, Garcia Rivello, Hernan J, Vera Janavel, Gustavo L, Cuniberti, Luis A, Cabeza Meckert, Patricia M, Yannarelli, Gustavo G, Mele, Anibal, Crottogini, Alberto J, Laguens, Ruben P

“…The multidrug-resistant (MDR)-1 gene-encoded P-glycoprotein (Pgp-170) is not normally present in the cardiomyocyte. Given that in other tissues Pgp-170 is not…”
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Absence of ischemic preconditioning protection in diabetic sheep hearts: role of sarcolemmal KATP channel dysfunction by del Valle, Héctor F, Lascano, Elena C, Negroni, Jorge A, Crottogini, Alberto J

“…Sarcolemmal ATP-sensitive potassium (KATP) channels have been mentioned to participate in preconditioning protection. Since these channels are altered in…”
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Expression of the MDR-1 Gene-encoded P-glycoprotein in Cardiomyocytes of Conscious Sheep Undergoing Acute Myocardial Ischemia Followed by Reperfusion by Laguens, Ruben P, Lazarowski, Alberto J, Cuniberti, Luis A, Vera Janavel, Gustavo L, Cabeza Meckert, Patricia M, Yannarelli, Gustavo G, del Valle, Hector F, Lascano, Elena C, Negroni, Jorge A, Crottogini, Alberto J

“…We have recently reported that in chronic myocardial ischemia, adult mammalian cardiomyocytes express P-glycoprotein (P-gp). We now investigate if P-gp is also…”
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Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep by DEL VALLE, Héctor Fabian, CATALINA LASCANO, Elena, ANTONIO NEGRONI, Jorge, JOSE CROTTOGINI, Alberto

“…Sulfonylureas have been associated with a high incidence of cardiovascular death in diabetic patients treated with these drugs. Although the evidence on the…”
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AT-muse cells allotransplantation in sheep with acute myocardial infarction improved left ventricular function regardless of non-effect on infarct size by Pedrozo, Cristian Nuñez, Cutine, Pablo, Giunta, Gustavo, Peralta, Tomas, Guevara, Eduardo, Cerdá, Miguel, Embón, Mario, Crottogini, Alberto, Cuniberti, Luis

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Contribution of myocardium hydraulic skeleton to left ventricular wall interaction and synergy in dogs by Barra, Juan Gabriel, Crottogini, Alberto José, Willshaw, Peter, Lascano, Elena Catalina, Pichel, Ricardo Horacio

“…The most premature motion change after coronary occlusion is early diastolic thinning of the ischemic left ventricular (LV) wall, with concomitant thickening…”
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ATP-sensitive potassium channels do not have a main role in mediating late preconditioning protection against arrhythmias and stunning in conscious sheep by Negroni, Jorge A, Lascano, Elena C, del Valle, Héctor F, Crottogini, Alberto J

“…Although late preconditioning protects against stunning following several short periods of ischemia-reperfusion, it is not clear if it confers protection…”
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Novel insights into cardiac regeneration based on differential fetal and adult ovine heart transcriptomic analysis by Locatelli, Paola, Belaich, Mariano N, López, Ayelén E, Olea, Fernanda D, Uranga Vega, Martín, Giménez, Carlos S, Simonin, Jorge Alejandro, Bauzá, María Del Rosario, Castillo, Marta G, Cuniberti, Luis A, Crottogini, Alberto, Cerrudo, Carolina S, Ghiringhelli, Pablo D

“…The adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and advance into mitosis. Therefore, diseases characterized by lost…”
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Impact of early post-stress 99m Tc sestamibi ECG-gated SPECT myocardial perfusion imaging on the detection of ischemic LV dyssynchrony: an early step in the stunning cascade by Cortés, Claudia Mariana, Aramayo G, E Natalia, Barboza, Paula Elizabeth, Crottogini, Alberto, Embon, Mario Alberto

“…Transient alterations in ventricular conduction and synchronized cardiac performance have been reported in experimental models of myocardial ischemia. In…”
Get full text