Search Results - "Crothers, D M"

Global Structure and Mechanical Properties of a 10-bp Nucleosome Positioning Motif by Roychoudhury, M, Sitlani, A, Lapham, J, Crothers, D M

“…The method of DNA cyclization kinetics reveals special properties of the TATAAACGCC sequence motif found in DNA sequences that have high affinity for core…”
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Artificial Nucleosome Positioning Sequences by Shrader, Thomas E., Crothers, Donald M.

“…We have used the emerging rules for the sequence dependence of DNA bendability to design and test a series of DNA molecules that incorporate strongly into…”
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Stability and Properties of Double and Triple Helices: Dramatic Effects of RNA or DNA Backbone Composition by Roberts, Richard W., Crothers, Donald M.

“…Studies of a series of short oligonucleotide double and triple helices containing either all RNA, all DNA, or a mixture of the two show strand-dependent…”
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Protein-Induced Bending and DNA Cyclization by Kahn, Jason D., Crothers, Donald M.

“…We have applied T4 ligase-mediated DNA cyclization kinetics to protein-induced bending in DNA. The presence and direction of a static bend can be inferred from…”
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Calibration of DNA Curvature and a Unified Description of Sequence-Directed Bending by Koo, Hyeon-Sook, Crothers, Donald M.

“…Chemically synthesized duplex oligodeoxynucleotides having different average numbers of adenine tracts (A6) per helix turn were ligated into multimers and…”
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RNA recognition by Tat-derived peptides: interaction in the major groove? by Weeks, K M, Crothers, D M

“…Replication of human immunodeficiency virus requires binding of the viral Tat protein to its RNA target sequence TAR; peptides derived from Tat bind to a TAR…”
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DNA Curvature and Deformation in Protein-DNA Complexes: A Step in the Right Direction by Crothers, Donald M.

“…Crothers discusses research examining the role the energy of DNA deformation plays in the thermodynamics and specificity of complex formation by proteins that…”
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Specificity and Stringency in DNA Triplex Formation by Roberts, Richard W., Crothers, Donald M.

“…Triple-helix formation can in principle serve as a general method for sequence-specific recognition and physical separation of duplex DNA molecules…”
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Detection of localized DNA flexibility by Kahn, Jason D, Yun, Elizabeth, Crothers, Donald M

“…The bending and flexibility of DNA are important in packaging, recombination and transcription. Bending decreases electrophoretic mobility in a manner…”
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Major Groove Accessibility of RNA by Weeks, Kevin M., Crothers, Donald M.

“…Chemical acylation experiments showed that the RNA major groove, often assumed to be too deep and narrow to permit recognition interactions, is accessible at…”
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Intrinsically bent DNA by CROTHERS, D. M, HARAN, T. E, NADEAU, J. G

“…Intrinsically bent or curved DNA molecules result when special base sequences or structural motifs are repeated in phase with the DNA helical repeat (…”
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Structural Basis for DNA Bending by Nadeau, James G., Crothers, Donald M.

“…We report proton NMR studies on DNA oligonucleotides that contain A tracts of lengths known to produce various degrees of bending. Spectra of duplexes in the…”
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Kinetics of an RNA Conformational Switch by LECUYER, K. A, CROTHERS, D. M

“…The spliced leader RNA from Leptomonas collosoma has two competing secondary structures of nearly equal free energy. Short, complementary oligonucleotides can…”
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Prediction of the Stability of DNA Triplexes by Roberts, Richard W., Crothers, Donald M.

“…We present rules that allow one to predict the stability of DNA pyrimidine· purine· pyrimidine (Y· R· Y) triple helices on the basis of the sequence. The rules…”
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Sliding and Intermolecular Transfer of the lac Repressor: Kinetic Perturbation of a Reaction Intermediate by a Distant DNA Sequence by Ruusala, Tarmo, Crothers, Donald M.

“…The lac repressor associates with its operator at a rate faster than conventional diffusion allows, either because of one-dimensional diffusion of a captured…”
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Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides by Baliga, Ramesh, Baird, Eldon E, Herman, David M, Melander, Christian, Dervan, Peter B, Crothers, Donald M

“…Polyamides composed of N-methylpyrrole (Py) and N-methylimidazole (Im) subunits can bind in the minor groove of DNA at predetermined sequences with…”
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Bent Helix Formation Between RNA Hairpins with Complementary Loops by Marino, John P., Gregorian, Razmic S., Csankovszki, Györgyi, Crothers, Donald M.

“…The initial interaction between the ColE1 plasmid specific transcripts RNA I and RNA II, which function as antisense regulators of plasmid replication,…”
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DNA bending at adenine · thymine tracts by Koo, Hyeon-Sook, Wu, Hen-Ming, Crothers, Donald M

“…Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA . dT which are at least 4 base pairs long; the A …”
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DNA bending, flexibility, and helical repeat by cyclization kinetics by Crothers, D M, Drak, J, Kahn, J D, Levene, S D

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Helical Repeat and Chirality Effects on DNA Gel Electrophoretic Mobility by Drak, Jacqueline, Crothers, Donald M.

“…We determined a value of 10.34 ± 0.04 base pairs (bp) per turn for the helical repeat of bent DNA sequences of the form A6N4--A6N5by estimating the sequence…”
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