Search Results - "Crother, Timothy R."

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis by Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Dagvadorj, Jargalsaikhan, Chiba, Norika, Chen, Shuang, Ramanujan, V. Krishnan, Wolf, Andrea J., Vergnes, Laurent, Ojcius, David M., Rentsendorj, Altan, Vargas, Mario, Guerrero, Candace, Wang, Yinsheng, Fitzgerald, Katherine A., Underhill, David M., Town, Terrence, Arditi, Moshe

“…We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of…”
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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation by Xian, Hongxu, Liu, Yuan, Rundberg Nilsson, Alexandra, Gatchalian, Raphaella, Crother, Timothy R., Tourtellotte, Warren G., Zhang, Yi, Aleman-Muench, German R., Lewis, Gavin, Chen, Weixuan, Kang, Sarah, Luevanos, Melissa, Trudler, Dorit, Lipton, Stuart A., Soroosh, Pejman, Teijaro, John, de la Torre, Juan Carlos, Arditi, Moshe, Karin, Michael, Sanchez-Lopez, Elsa

“…Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by…”
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Immunological Consequences of Intestinal Fungal Dysbiosis by Wheeler, Matthew L., Limon, Jose J., Bar, Agnieszka S., Leal, Christian A., Gargus, Matthew, Tang, Jie, Brown, Jordan, Funari, Vincent A., Wang, Hanlin L., Crother, Timothy R., Arditi, Moshe, Underhill, David M., Iliev, Iliyan D.

“…Compared to bacteria, the role of fungi within the intestinal microbiota is poorly understood. In this study we investigated whether the presence of a…”
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Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis by Tumurkhuu, Gantsetseg, Shimada, Kenichi, Dagvadorj, Jargalsaikhan, Crother, Timothy R, Zhang, Wenxuan, Luthringer, Daniel, Gottlieb, Roberta A, Chen, Shuang, Arditi, Moshe

“…RATIONALE:Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome-mediating interleukin (IL)-1β…”
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Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice by Skalski, Joseph H, Limon, Jose J, Sharma, Purnima, Gargus, Matthew D, Nguyen, Christopher, Tang, Jie, Coelho, Ana Lucia, Hogaboam, Cory M, Crother, Timothy R, Underhill, David M

“…The gastrointestinal microbiota influences immune function throughout the body. The gut-lung axis refers to the concept that alterations of gut commensal…”
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Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release by Dagvadorj, Jargalsaikhan, Shimada, Kenichi, Chen, Shuang, Jones, Heather D., Tumurkhuu, Gantsetseg, Zhang, Wenxuan, Wawrowsky, Kolja A., Crother, Timothy R., Arditi, Moshe

“…Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We…”
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Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation by Noval Rivas, Magali, Wakita, Daiko, Franklin, Michael K., Carvalho, Thacyana T., Abolhesn, Amanda, Gomez, Angela C., Fishbein, Michael C., Chen, Shuang, Lehman, Thomas J., Sato, Kazuki, Shibuya, Akira, Fasano, Alessio, Kiyono, Hiroshi, Abe, Masanori, Tatsumoto, Narihito, Yamashita, Michifumi, Crother, Timothy R., Shimada, Kenichi, Arditi, Moshe

“…Recent experimental data and clinical, genetic, and transcriptome evidence from patients converge to suggest a key role of interleukin-1β (IL-1β) in the…”
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NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis by Porritt, Rebecca A., Zemmour, David, Abe, Masanori, Lee, Youngho, Narayanan, Meena, Carvalho, Thacyana T., Gomez, Angela C., Martinon, Daisy, Santiskulvong, Chintda, Fishbein, Michael C., Chen, Shuang, Crother, Timothy R., Shimada, Kenichi, Arditi, Moshe, Noval Rivas, Magali

“…[Figure: see text]…”
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Loss of testosterone impairs anti-tumor neutrophil function by Markman, Janet L., Porritt, Rebecca A., Wakita, Daiko, Lane, Malcolm E., Martinon, Daisy, Noval Rivas, Magali, Luu, Michael, Posadas, Edwin M., Crother, Timothy R., Arditi, Moshe

“…In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role…”
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Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury by Nosaka, Nobuyuki, Martinon, Daisy, Moreira, Debbie, Crother, Timothy R, Arditi, Moshe, Shimada, Kenichi

“…Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and…”
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Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer by Lowe, Emily L, Crother, Timothy R, Rabizadeh, Shervin, Hu, Bing, Wang, Hanlin, Chen, Shuang, Shimada, Kenichi, Wong, Michelle H, Michelsen, Kathrin S, Arditi, Moshe

“…Inflammatory bowel disease (IBD) is a disorder of chronic inflammation with increased susceptibility to colorectal cancer. The etiology of IBD is unclear but…”
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The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury by Jones, Heather D, Crother, Timothy R, Gonzalez-Villalobos, Romer A, Jupelli, Madhulika, Chen, Shuang, Dagvadorj, Jargalsaikhan, Arditi, Moshe, Shimada, Kenichi

“…IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and…”
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Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic Aneurysm by Wakita, Daiko, Kurashima, Yosuke, Crother, Timothy R, Noval Rivas, Magali, Lee, Youngho, Chen, Shuang, Fury, Wen, Bai, Yu, Wagner, Shawn, Li, Debiao, Lehman, Thomas, Fishbein, Michael C, Hoffman, Hal M, Shah, Prediman K, Shimada, Kenichi, Arditi, Moshe

“…OBJECTIVE—Kawasaki disease (KD) is the most common cause of acquired cardiac disease in US children. In addition to coronary artery abnormalities and…”
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Chlamydia pneumoniae in Alzheimer's disease pathology by Subedi, Lalita, Gaire, Bhakta Prasad, Koronyo, Yosef, Koronyo-Hamaoui, Maya, Crother, Timothy R

“…While recent advances in diagnostics and therapeutics offer promising new approaches for Alzheimer's disease (AD) diagnosis and treatment, there is still an…”
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Mitochondrial quality control in health and cardiovascular diseases by Atici, Asli E., Crother, Timothy R., Noval Rivas, Magali

“…Cardiovascular diseases (CVDs) are one of the primary causes of mortality worldwide. An optimal mitochondrial function is central to supplying tissues with…”
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IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice by Chen, Shuang, Shimada, Kenichi, Zhang, Wenxuan, Huang, Ganghua, Crother, Timothy R, Arditi, Moshe

“…The role of IL-17 in atherogenesis remains controversial. We previously reported that the TLR/MyD88 signaling pathway plays an important role in high-fat diet…”
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Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model by Tumurkhuu, Gantsetseg, Chen, Shuang, Montano, Erica N, Ercan Laguna, Duygu, De Los Santos, Gabriela, Yu, Jeong Min, Lane, Malcolm, Yamashita, Michifumi, Markman, Janet L, Blanco, Luz P, Kaplan, Mariana J, Shimada, Kenichi, Crother, Timothy R, Ishimori, Mariko, Wallace, Daniel J, Jefferies, Caroline A, Arditi, Moshe

“…Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be…”
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MD-2 as a possible therapeutic target for atherosclerosis by Chen, Shuang, Crother, Timothy R.

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Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis by Jupelli, Madhulika, Shimada, Kenichi, Chiba, Norika, Slepenkin, Anatoly, Alsabeh, Randa, Jones, Heather D, Peterson, Ellena, Chen, Shuang, Arditi, Moshe, Crother, Timothy R

“…Chlamydia pneumoniae (CP) lung infection can induce chronic lung inflammation and is associated with not only acute asthma but also COPD exacerbations…”
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Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection by Shimada, Kenichi, Crother, Timothy R, Karlin, Justin, Chen, Shuang, Chiba, Norika, Ramanujan, V Krishnan, Vergnes, Laurent, Ojcius, David M, Arditi, Moshe

“…Chlamydia pneumoniae (CP) is an important human pathogen that causes atypical pneumonia and is associated with various chronic inflammatory disorders…”
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