Search Results - "Croteau, Rodney B"

Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase by Srividya, Narayanan, Davis, Edward M., Croteau, Rodney B., Lange, B. Markus

“…Significance Terpene synthases catalyze complex, chain length-specific, electrophilic cyclization reactions that constitute the first committed step in the…”
Get full text

Draft Genome Sequence of Mentha longifolia and Development of Resources for Mint Cultivar Improvement by Vining, Kelly J., Johnson, Sean R., Ahkami, Amirhossein, Lange, Iris, Parrish, Amber N., Trapp, Susan C., Croteau, Rodney B., Straub, Shannon C.K., Pandelova, Iovanna, Lange, B. Markus

“…The genus Mentha encompasses mint species cultivated for their essential oils, which are formulated into a vast array of consumer products. Desirable oil…”
Get full text

Improving peppermint essential oil yield and composition by metabolic engineering by Lange, Bernd Markus, Mahmoud, Soheil Seyed, Wildung, Mark R, Turner, Glenn W, Davis, Edward M, Lange, Iris, Baker, Raymond C, Boydston, Rick A, Croteau, Rodney B

“…Peppermint (Mentha x piperita L.) was transformed with various gene constructs to evaluate the utility of metabolic engineering for improving essential oil…”
Get full text

Structure of limonene synthase, a simple model for terpenoid cyclase catalysis by Hyatt, David C, Youn, Buhyun, Zhao, Yuxin, Santhamma, Bindu, Coates, Robert M, Croteau, Rodney B, Kang, ChulHee

“…The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and…”
Get full text

Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae by DeJong, JingHong M., Liu, Yule, Bollon, Arthur P., Long, Robert M., Jennewein, Stefan, Williams, David, Croteau, Rodney B.

“…Baccatin III, an intermediate of Taxol biosynthesis and a useful precursor for semisynthesis of the anti‐cancer drug, is produced in yew (Taxus) species by a…”
Get full text

systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint by Rios-Estepa, Rigoberto, Turner, Glenn W, Lee, James M, Croteau, Rodney B, Lange, B. Markus

“…The integration of mathematical modeling and experimental testing is emerging as a powerful approach for improving our understanding of the regulation of…”
Get full text

Strategies for transgenic manipulation of monoterpene biosynthesis in plants by Mahmoud, Soheil S, Croteau, Rodney B

“…Monoterpenes, the C 10 isoprenoids, are a large family of natural products that are best known as constituents of the essential oils and defensive oleoresins…”
Get full text

Bornyl Diphosphate Synthase: Structure and Strategy for Carbocation Manipulation by a Terpenoid Cyclase by Whittington, Douglas A., Wise, Mitchell L., Urbansky, Marek, Coates, Robert M., Croteau, Rodney B., Christianson, David W.

“…The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring monoterpene cyclase from Salvia officinalis, is reported at 2.0-Å…”
Get full text

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants by Cuthbertson, Daniel J., Johnson, Sean R., Piljac-Žegarac, Jasenka, Kappel, Julia, Schäfer, Sarah, Wüst, Matthias, Ketchum, Raymond E.B., Croteau, Rodney B., Marques, Joaquim V., Davin, Laurence B., Lewis, Norman G., Rolf, Megan, Kutchan, Toni M., Soejarto, D. Doel, Lange, B. Markus

“…We report the development and testing of an accurate mass–time tag library for plant natural product profiling. [Display omitted] ► The development of an…”
Get full text

Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase by Mahmoud, S.S, Croteau, R.B

“…(+)-Pulegone is a central intermediate in the biosynthesis of (-)-menthol, the most significant component of peppermint essential oil. Depending on…”
Get full text

NMR spectroscopic search module for Spektraris, an online resource for plant natural product identification – Taxane diterpenoids from Taxus×media cell suspension cultures as a case study by Fischedick, Justin T., Johnson, Sean R., Ketchum, Raymond E.B., Croteau, Rodney B., Lange, B. Markus

“…Development and testing of Spektraris-NMR – a resource for identifying known plant natural products based on NMR spectra. [Display omitted] •Introduction of…”
Get full text

Developmental Regulation of Monoterpene Biosynthesis in the Glandular Trichomes of Peppermint by Marie E. Mc Conkey, Gershenzon, Jonathan, Croteau, Rodney B.

“…Monoterpene production in peppermint (Mentha × piperita L.) glandular trichomes is determined by the rate of biosynthesis, as determined by 14CO2…”
Get full text

Distribution of Peltate Glandular Trichomes on Developing Leaves of Peppermint by Turner, Glenn W., Gershenzon, Jonathan, Croteau, Rodney B.

“…The pattern of peltate glandular trichome initiation and ontogeny on expanding peppermint (Mentha × piperita) leaves was defined by surveying the populations…”
Get full text

Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures by Ketchum, Raymond E.B., Rithner, Christopher D., Qiu, Deyou, Kim, You Sun, Williams, Robert M., Croteau, Rodney B.

“…Cells from suspension cultures of Taxus cuspidata were extracted with pentane as a source of relatively non-polar taxoids. Of the 13 taxoids identified in this…”
Get full text

Genetic engineering of peppermint for improved essential oil composition and yield by Wildung, M.R, Croteau, R.B

“…The biochemistry, organization, and regulation of essential oil metabolism in the epidermal oil glands of peppermint have been defined, and most of the genes…”
Get full text

Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases by Peters, Reuben J, Croteau, Rodney B

“…Monoterpene cyclization reactions are initiated by ionization and isomerization of geranyl diphosphate, and proceed, via cyclization of bound linalyl…”
Get full text

Bifunctional Abietadiene Synthase:  Mutual Structural Dependence of the Active Sites for Protonation-Initiated and Ionization-Initiated Cyclizations by Peters, Reuben J, Carter, Ora A, Zhang, Yan, Matthews, Brian W, Croteau, Rodney B

“…Abietadiene synthase from grand fir catalyzes two sequential, mechanistically distinct cyclizations, of geranylgeranyl diphosphate and of copalyl diphosphate,…”
Get full text

Hydroxylation of Specifically Deuterated Limonene Enantiomers by Cytochrome P450 Limonene-6-Hydroxylase Reveals the Mechanism of Multiple Product Formation by Wüst, Matthias, Croteau, Rodney B

“…The regiochemistry and facial stereochemistry of the limonene-6-hydroxylase- (CYP71D18-) mediated hydroxylation of the monoterpene olefin limonene are…”
Get full text

Abietadiene Synthase Catalysis: Mutational Analysis of a Prenyl Diphosphate Ionization-Initiated Cyclization and Rearrangement by Peters, Reuben J., Croteau, Rodney B.

“…Abietadiene synthase catalyzes the committed step in resin acid biosynthesis, forming a mixture of abietadiene double-bond isomers by two sequential,…”
Get full text

Metabolic Engineering of Essential Oil Yield and Composition in Mint by Altering Expression of Deoxyxylulose Phosphate Reductoisomerase and Menthofuran Synthase by Mahmoud, S S, Croteau, R B

“…Peppermint (Mentha × piperita L.) was independently transformed with a homologous sense version of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase cDNA and…”
Get full text