Search Results - "Croston, Glenn E"

Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells by Iampietro, Corinne, Brossa, Alessia, Canosa, Stefano, Tritta, Stefania, Croston, Glenn E, Reinheimer, Torsten Michael, Bonelli, Filippo, Carosso, Andrea Roberto, Gennarelli, Gianluca, Cosma, Stefano, Benedetto, Chiara, Revelli, Alberto, Bussolati, Benedetta

“…Endometrial mesenchymal stromal cells (E-MSCs) extensively contribute to the establishment and progression of endometrial ectopic lesions through formation of…”
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Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers by Schmidt, William K., Cortés‐Puch, Irene, McReynolds, Cindy B., Croston, Glenn E., Hwang, Sung Hee, Yang, Jun, Pedersen, Theresa L., Wagner, Karen M., Pham, Theresa T., Hunt, Thomas, Hammock, Bruce D.

“…Chronic pain represents a significant unmet medical need, affecting one‐fifth of the U.S. population. EC5026 is a small molecule inhibitor of the enzyme…”
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The utility of target-based discovery by Croston, Glenn E

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Comparative pharmacology of a new recombinant FSH expressed by a human cell line by Koechling, Wolfgang, Plaksin, Daniel, Croston, Glenn E, Jeppesen, Janni V, Macklon, Kirsten T, Andersen, Claus Yding

“…Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO)…”
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Protective Mechanism of the Selective Vasopressin V 1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction by Barabutis, Nektarios, Marinova, Margarita, Solopov, Pavel, Uddin, Mohammad A, Croston, Glenn E, Reinheimer, Torsten M, Catravas, John D

“…Sepsis and septic shock are among the most common causes of death in the intensive care unit; advanced therapeutic approaches are thus urgently needed…”
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Identification of novel subtype selective RAR agonists by Piu, Fabrice, Gauthier, Natalie K., Olsson, Roger, Currier, Erika A., Lund, Birgitte W., Croston, Glenn E., Hacksell, Uli, Brann, Mark R.

“…Drugs targeting retinoid receptors have been developed to treat a variety of therapeutic indications, but their success has been limited in part due to lack of…”
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75 Green Businesses You Can Start to Make Money and Make a Difference: You Can Start to Make Money and Make a Difference by Croston, Glenn

“…With environmental concerns a top issue for consumers everywhere, the green market is the next big boom industry for entrepreneurs looking to make money-and…”
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Activation of specific RXR heterodimers by an antagonist of RXR homodimers by Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A

“…Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent…”
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Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes by Croston, Glenn E, Milan, Loribelle B, Marschke, Keith B, Reichman, Melvin, Briggs, Michael R

“…Postmenopausal women receiving hormone replacement therapy have a lower risk of coronary heart disease than women who do not receive hormone treatment…”
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Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription by Croston, Glenn E., Kerrigan, Leslie A., Lira, Lucy M., Marshak, Daniel R., Kadonaga, James T.

“…To understand the principles of control and selectivity in gene expression, the biochemical mechanisms by which promoter- and enhancer-binding factors regulate…”
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Functional cell-based uHTS in chemical genomic drug discovery by Croston, Glenn E

“…The availability of genomic information significantly increases the number of potential targets available for drug discovery, although the function of many…”
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Identification of the First Retinoid X Receptor Homodimer Antagonist by Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M

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A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes by Mukherjee, Ranjan, Hoener, Patricia A, Jow, Lily, Bilakovics, James, Klausing, Kay, Mais, Dale E, Faulkner, Amy, Croston, Glenn E, Paterniti Jr, James R

“…Peroxisome proliferator-activated receptor-γ (PPARγ) agonists such as the thiazolidinediones are insulin sensitizers used in the treatment of type 2 diabetes…”
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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor:  3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954) by Croston, Glenn E, Olsson, Roger, Currier, Erika A, Burstein, Ethan S, Weiner, David, Nash, Norman, Severance, Daniel, Allenmark, Stig G, Thunberg, Linda, Ma, Jian-Nong, Mohell, Nina, O'Dowd, Brian, Brann, Mark R, Hacksell, Uli

“…A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of…”
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Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells by Canan Koch, Stacie S, Dardashti, Laura J, Cesario, Rosemary M, Croston, Glenn E, Boehm, Marcus F, Heyman, Richard A, Nadzan, Alex M

“…A novel series of oxime ligands has been synthesized that displays potent, specific activation of the retinoid X receptors (RXRs). The oximes of 3-substituted…”
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Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists by Mukherjee, Ranjan, Jow, Lily, Croston, Glenn E., Paterniti, James R.

“…We describe the cloning, characterization, and tissue distribution of the two human peroxisome proliferator activated receptor isoforms hPPARγ2 and hPPARγ1. In…”
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NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity by Croston, Glenn E., Cao, Zhaodan, Goeddel, David V.

“…An important function of interleukin-1 (IL-1) is activation of the transcription factor NF-κB, which is signaled via the type I IL-1 receptor (IL-1RI). By…”
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Mechanism of transcriptional antirepression by GAL4-VP16 by CROSTON, G. E, LAYBOURN, P. J, PARANJAPE, S. M, KADONAGA, J. T

“…Promoter- and enhancer-binding factors appear to function by facilitating the transcription reaction as well as by counteracting chromatin-mediated repression…”
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Role of chromatin structure in the regulation of transcription by RNA polymerase II by Croston, G E, Kadonaga, J T

“…Recent studies on chromatin have concentrated on the relationship between its structure and gene activity. This topic, which addresses the fundamental…”
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NF-B Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity by Glenn E. Croston, Zhaodan Cao, David V. Goeddel

“…An important function of interleukin-1 (IL-1) is activation of the transcription factor NF-κB, which is signaled via the type I IL-1 receptor (IL-1RI). By…”
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