Search Results - "Cross, Michael J."

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues by Ravenscroft, Stephanie M, Pointon, Amy, Williams, Awel W, Cross, Michael J, Sidaway, James E

“…The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their use in translational medicine and pre-clinical in vitro drug…”
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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 by Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin

“…The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules…”
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Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity by Pointon, Amy, Abi-Gerges, Najah, Cross, Michael J, Sidaway, James E

“…Morphological damage to cardiomyocytes or loss of viability (structural cardiotoxicity) is a common cause of attrition in preclinical and clinical drug…”
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Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro by da Silva, Tamiris Borges, Rendra, Erika, David, Christopher A.W., Bieback, Karen, Cross, Michael J., Wilm, Bettina, Liptrott, Neill J., Murray, Patricia

“…Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a…”
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Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability by Wilkinson, Emma L, Sidaway, James E, Cross, Michael J

“…Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in…”
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Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway by Tomlinson, Lauren, Lu, Zhen Qi, Bentley, Robert A, Colley, Helen E., Murdoch, Craig, Webb, Steven D., Cross, Michael J., Copple, Ian M., Sharma, Parveen

“…[Display omitted] •Cardiac damage is a major adverse reaction in the treatment of cancer patients.•After secondary malignancy cardiovascular disease major…”
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The role of ERK5 in endothelial cell function by Nithianandarajah-Jones, Gopika N, Wilm, Bettina, Goldring, Christopher E P, Müller, Jürgen, Cross, Michael J

“…Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase…”
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Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival by Muñiz-García, Ana, Wilm, Bettina, Murray, Patricia, Cross, Michael J

“…Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have emerged as novel tools in regenerative medicine. Angiogenesis modulation is widely…”
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Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells by Koukorava, Chrysa, Ahmed, Katie, Almaghrabi, Shrouq, Pointon, Amy, Haddrick, Malcolm, Cross, Michael J

“…Cardiotoxicity can be defined as "chemically induced heart disease", which can occur with many different drug classes treating a range of diseases. It is the…”
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ERK5 and the regulation of endothelial cell function by Roberts, Owain Llŷr, Holmes, Katherine, Müller, Jürgen, Cross, Darren A E, Cross, Michael J

“…ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of…”
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Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis by Mellberg, Sofie, Dimberg, Anna, Bahram, Fuad, Hayashi, Makoto, Rennel, Emma, Ameur, Adam, Westholm, Jakub Orzechowski, Larsson, Erik, Lindahl, Per, Cross, Michael J, Claesson-Welsh, Lena

“…To define molecular events accompanying formation of the 3-dimensional (3D) vascular tube, we have characterized gene expression during vascular endothelial…”
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N-Heterocyclic Carbenes as Highly Efficient Catalysts for the Cyclotrimerization of Isocyanates by Duong, Hung A, Cross, Michael J, Louie, Janis

“…A series of N-heterocyclic carbenes (NHCs) were evaluated as potential catalysts for the cyclotrimerization of isocyanates to afford isocyanurates…”
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VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta by Holmes, Katherine, Chapman, Elinor, See, Violaine, Cross, Michael J

“…Vascular endothelial growth factor (VEGF) has previously been shown to upregulate the expression of the endogenous calcineurin inhibitor, regulator of…”
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Nickel-Catalyzed Cycloaddition of Alkynes and Isocyanates by Duong, Hung A, Cross, Michael J, Louie, Janis

“…A mild and general route for preparing 2-pyridones from isocyanates and diynes is described. Ni imidazolyidene complexes were used to mediate cyclizations…”
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Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay by Koukorava, Chrysa, Ward, Kelly, Ahmed, Katie, Almaghrabi, Shrouq, Dauleh, Sumaya, Pereira, Sofia M, Taylor, Arthur, Haddrick, Malcolm, Cross, Michael J, Wilm, Bettina

“…Mesothelial cells have been shown to have remarkable plasticity towards mesenchymal cell types during development and in disease situations. Here, we have…”
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The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration by Holmqvist, Kristina, Cross, Michael J, Rolny, Charlotte, Hägerkvist, Robert, Rahimi, Nader, Matsumoto, Taro, Claesson-Welsh, Lena, Welsh, Michael

“…Previous studies have shown that the adaptor protein Shb is involved in receptor tyrosine kinase signaling. In this study, we demonstrate that Shb is…”
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VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells by Mondru, Anil Kumar, Aljasir, Mohammad A, Alrumayh, Ahmed, Nithianandarajah, Gopika N, Ahmed, Katie, Muller, Jurgen, Goldring, Christopher E P, Wilm, Bettina, Cross, Michael J

“…Extracellular-signal-regulated kinase 5 (ERK5) is critical for normal cardiovascular development. Previous studies have defined a canonical pathway for ERK5…”
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ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells by Roberts, Owain Llŷr, Holmes, Katherine, Müller, Jürgen, Cross, Darren A.E, Cross, Michael J

“…Extracellular signal-regulated kinase 5 (ERK5) is activated in response to environmental stress and growth factors. Gene ablation of Erk5 in mice is…”
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Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells by Nithianandarajah-Jones, Gopika N, Cross, Michael J

“…Extracellular signal-regulated kinase 5 (ERK5), also known as big MAPK (BMK1), is the most recently identified member of the mitogen-activated kinase pathway…”
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Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition by Holmes, Katherine, Roberts, Owain Ll, Thomas, Angharad M., Cross, Michael J.

“…Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is…”
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