Search Results - "Cross, MJ"

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition by Cross, Michael J, Claesson-Welsh, Lena

“…Angiogenic growth factors such as fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGFs) are currently targets of intense efforts to…”
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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms by Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.

“…The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new…”
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How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? by Laverty, HG, Benson, C, Cartwright, EJ, Cross, MJ, Garland, C, Hammond, T, Holloway, C, McMahon, N, Milligan, J, Park, BK, Pirmohamed, M, Pollard, C, Radford, J, Roome, N, Sager, P, Singh, S, Suter, T, Suter, W, Trafford, A, Volders, PGA, Wallis, R, Weaver, R, York, M, Valentin, JP

“…Given that cardiovascular safety liabilities remain a major cause of drug attrition during preclinical and clinical development, adverse drug reactions, and…”
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VEGF-receptor signal transduction by Cross, Michael J., Dixelius, Johan, Matsumoto, Taro, Claesson-Welsh, Lena

“…The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There…”
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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 by Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin

“…The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules…”
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Abstract P5-15-09: A new method for marking the lumpectomy cavity during oncoplastic surgery and breast conservation by Glaser, CC, Cross, MJ, Harman, J

“…Abstract Background: Oncoplastic surgery has dramatically improved patient outcomes following breast conservation, however, most patients require adjuvant…”
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N-Heterocyclic Carbenes as Highly Efficient Catalysts for the Cyclotrimerization of Isocyanates by Duong, Hung A, Cross, Michael J, Louie, Janis

“…A series of N-heterocyclic carbenes (NHCs) were evaluated as potential catalysts for the cyclotrimerization of isocyanates to afford isocyanurates…”
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Nickel-Catalyzed Cycloaddition of Alkynes and Isocyanates by Duong, Hung A, Cross, Michael J, Louie, Janis

“…A mild and general route for preparing 2-pyridones from isocyanates and diynes is described. Ni imidazolyidene complexes were used to mediate cyclizations…”
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The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration by Holmqvist, Kristina, Cross, Michael J, Rolny, Charlotte, Hägerkvist, Robert, Rahimi, Nader, Matsumoto, Taro, Claesson-Welsh, Lena, Welsh, Michael

“…Previous studies have shown that the adaptor protein Shb is involved in receptor tyrosine kinase signaling. In this study, we demonstrate that Shb is…”
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Abstract P3-13-04: Use of an absorbable implant to mark the lumpectomy cavity: Initial report of 300 patients in a multi-center registry database by Kaufman, CS, Cross, MJ, Goyal, S, Barone, J, Devisetty, K, Dekhne, NS, Edmonson, D, Gass, JS, Graham, CL, Hong, RL, Patton, BJ, Phillips, RF, Schonholz, SM, Smith, LA, Tafra, L, Smith, AB, Dilworth, J

“…Abstract Objective: Increased use of oncoplastic procedures makes it difficult to distinguish the lumpectomy margins from seroma fluid. Many side effects of…”
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Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways by Eriksson, Kerstin, Magnusson, Peetra, Dixelius, Johan, Claesson-Welsh, Lena, Cross, Michael J

“…The anti-angiogenic agents angiostatin and endostatin have been shown to affect endothelial cell migration in a number of studies. We have examined the effect…”
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Patient self-efficacy and health locus of control: relationships with health status and arthritis-related expenditure by Cross, M. J., March, L. M., Lapsley, H. M., Byrne, E., Brooks, P. M.

“…Objective. To explore the relationship between measures of self-efficacy, health locus of control, health status and direct medical expenditure among…”
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Training and match load in professional rugby union: Do contextual factors influence the training week? by West, Stephen W, Williams, Sean, Tierney, Peter, Batchelor, Tom, Cross, Matthew J, Kemp, Simon P T, Stokes, Keith A

“…Background: Rugby union demands a multifaceted approach to training, given the multiple physical and technical attributes required to play the sport…”
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A comparison of outcomes in osteoarthritis patients undergoing total hip and knee replacement surgery by Bachmeier, C.J.M., March, L.M., Cross, M.J., Lapsley, H.M., Tribe, K.L., Courtenay, B.G., Brooks, P.M.

“…Objective The aims of this study were to assess changes in physical function and quality of life with the Western Ontario and McMaster Universities…”
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End-to-end SARS-CoV-2 transmission risks in sport: Current evidence and practical recommendations by Jones, Ben, Phillips, Gemma, Valeriani, Federica, Edwards, Thomas, Adams, Emily, Bonadonna, Lucia, Copeland, Robert, Cross, Matthew, Dalton, Caroline, Hodgson, Lisa, Jimenez, Alfonso, Kemp, Simon, Patricios, Jon, Romano Spica, Vincenzo, Stokes, Keith, Weed, Mike, Beggs, Clive

“…The coronavirus disease 2019 (COVID-19) pandemic has caused disruption to professional and recreational sports across the world. The SARS-CoV-2 virus can be…”
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Two knees or not two knees? by March, L.M., Cross, M., Tribe, K.L., Lapsley, H.M., Courtenay, B.G., Cross, M.J., Brooks, P.M.

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Rhodium-catalyzed addition of alcohols to terminal enones by Farnworth, Marc V., Cross, Michael J., Louie, Janis

“…[Display omitted] [Rh(COD)(OMe)]2 was found to catalyze the addition of aliphatic and aromatic alcohols with terminal enones to afford β-alkoxyketones in high…”
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Endostatin action and intracellular signaling: β-catenin as a potential target? by Dixelius, Johan, Cross, Michael J, Matsumoto, Taro, Claesson-Welsh, Lena

“…Endostatin, the C-terminal part of collagen XVIII, has been shown to inhibit blood vessel formation in different pathological conditions characterized by…”
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The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells by Cross, Michael J, Lu, Lingge, Magnusson, Peetra, Nyqvist, Daniel, Holmqvist, Kristina, Welsh, Michael, Claesson-Welsh, Lena

“…Stimulation of fibroblast growth factor receptor-1 (FGFR-1) is known to result in phosphorylation of tyrosine 766 and the recruitment and subsequent activation…”
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Outcomes after hip or knee replacement surgery for osteoarthritis: A prospective cohort study comparing patients' quality of life before and after surgery with age-related population norms by MARCH, L. M, CROSS, M. J, LAPSLEY, H, BRNABIC, A. J. M, TRIBE, K. L, BACHMEIER, C. J. M, COURTENAY, B. G, BROOKS, P. M

“…To compare the health-related quality of life of people with osteoarthritis before and after primary total hip and knee replacement surgery with that of the…”
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